Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Tiama Hamkins-Indik"'
Autor:
Remi Villenave, Samantha Q Wales, Tiama Hamkins-Indik, Efstathia Papafragkou, James C Weaver, Thomas C Ferrante, Anthony Bahinski, Christopher A Elkins, Michael Kulka, Donald E Ingber
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0169412 (2017)
Analysis of enterovirus infection is difficult in animals because they express different virus receptors than humans, and static cell culture systems do not reproduce the physical complexity of the human intestinal epithelium. Here, using coxsackievi
Externí odkaz:
https://doaj.org/article/81c1e3f16dda46bfb689119331286832
Autor:
Anna Herland, Ben Swenor, Daniel Levner, Olivier Y.F. Henry, Sasan Jalili-Firoozinezhad, Angeliki Chalkiadaki, Henry Sanchez, Andrzej Przekwas, Sauveur S. F. Jeanty, Rachelle Prantil-Baun, Josiah Sliz, Youngjae Choe, Kyung-Jin Jang, Moran Yadid, Susan Marquez, Chris Hinojosa, Thomas C. Ferrante, Blakely B. O'Connor, Tiama Hamkins-Indik, Rachel Fleming, Stephanie Dauth, Janna Nawroth, Morgan Burt, Ben M. Maoz, David B. Chou, Aaron Delahanty, John P. Ferrier, Anthony Bahinski, Jose Fernandez-Alcon, Bret Nestor, Guy Robert Thompson, Lian Leng, Robert Mannix, Michael J. Cronce, Yuka Milton, Mahadevabharath R. Somayaji, Alexandra Sontheimer-Phelps, Tae-Eun Park, Miles Ingram, Edward A. FitzGerald, Debarun Das, Ville J. Kujala, Josue A. Goss, George J. Touloumes, Toni Divic, Carlos F. Ng, Oren Levy, Zachary Tranchemontagne, Elizabeth Calamari, Geraldine A. Hamilton, Alexander Cho, Thomas Grevesse, Norman Wen, Tessa Huffstater, Donald E. Ingber, Kevin Kit Parker, Richard M. Novak
Publikováno v:
Nature Biomedical Engineering. 4:407-420
Organ chips can recapitulate organ-level (patho)physiology, yet pharmacokinetic and pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we describe an 'interrogator' that employs liquid-handling robotics, custom s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea94accc104e59d5af0303d98dc1c94f
https://doi.org/10.1038/s41551-019-0497-x
https://doi.org/10.1038/s41551-019-0497-x
Autor:
Chiara Fedele, Elina Mäntylä, Brian Belardi, Tiama Hamkins-Indik, Silvia Cavalli, Paolo A. Netti, Daniel A. Fletcher, Soile Nymark, Arri Priimagi, Teemu O. Ihalainen
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Surface topography is a key parameter in regulating the morphology and behavior of single cells. At multicellular level, coordinated cell displacements drive many biological events such as embryonic morphogenesis. However, the effect of surface topog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e52094f77d2ef0b7f82a9eb8a21c4406
http://europepmc.org/articles/PMC7501301
http://europepmc.org/articles/PMC7501301
Autor:
Ke Xu, Andrew R. Harris, Jeongmin Kim, Brian Belardi, Daniel A. Fletcher, Tiama Hamkins-Indik
Publikováno v:
Dev Cell
In vertebrates, epithelial permeability is regulated by the tight junction (TJ) formed by specialized adhesive membrane proteins, adaptor proteins, and the actin cytoskeleton. Despite the TJ's critical physiological role, a molecular-level understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75207d887fec944a25d6622986b180cd
https://pubmed.ncbi.nlm.nih.gov/32841596
https://pubmed.ncbi.nlm.nih.gov/32841596
SUMMARYIn vertebrates, epithelial permeability is regulated by the tight junction (TJ) formed by specialized adhesive membrane proteins, adaptor proteins, and the actin cytoskeleton. Despite the TJ’s critical physiological role, a molecular-level u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a398d6e35eefdadcc8abc31b998a09e
https://doi.org/10.1101/805689
https://doi.org/10.1101/805689
Autor:
Ben M. Maoz, Sasan Jalili-Firoozinezhad, Andrzej Przekwas, Carlos F. Ng, Alexander Cho, Anna Herland, Jose Fernandez-Alcon, Daniel Levner, Olivier Y.F. Henry, Janna Nawroth, Blakely B. O'Connor, Debarun Das, David B. Chou, Kevin Kit Parker, Anthony Bahinski, Morgan Burt, Ville J. Kujala, Susan Clauson, Mahadevabharath R. Somayaji, Thomas C. Ferrante, Ben Swenor, Henry Sanchez, Lian Leng, Tessa Huffstater, Angeliki Chalkiadaki, Miles Ingram, Donald E. Ingber, Tiama Hamkins-Indik, Norman Wen, Rachelle Prantil-Baun, Youngjae Choe, Josiah Sliz, Zachary Tranchemontagne, Bret Nestor, George J. Touloumes, Rachel Fleming, Guy Robert Thompson, Alexandra Sontheimer-Phelps, Josue A. Goss, Oren Levy, Toni Divic, Elizabeth Calamari, Sauveur S. F. Jeanty, Kyung-Jin Jang, Michael J. Cronce, Yuka Milton, Richard M. Novak, Geraldine A. Hamilton, Thomas Grevesse, Chris Hinojosa, Moran Yadid, Stephanie Dauth, John P. Ferrier, Tae-Eun Park, Robert Mannix, Edward A. FitzGerald, Aaron Delahanty
Publikováno v:
Nat Biomed Eng
Here we describe of an ‘Interrogator’ instrument that uses liquid-handling robotics, a custom software package, and an integrated mobile microscope to enable automated culture, perfusion, medium addition, fluidic linking, sample collection, andin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91904c828996f1d91cb14b8c52e98514
https://doi.org/10.1101/569541
https://doi.org/10.1101/569541
Autor:
Marinke van der Helm, Mathieu Odijk, Andries D. van der Meer, Olivier Y.F. Henry, Donald E. Ingber, Jan C.T. Eijkel, Amir Bein, William D. Leineweber, Loes I. Segerink, Tiama Hamkins-Indik, Albert van den Berg, Michael J. Cronce
Publikováno v:
Lab on a Chip
Lab on a chip, 19(3), 452-463. Royal Society of Chemistry
Lab on a chip, 19(3), 452-463. Royal Society of Chemistry
Here, we describe methods for combining impedance spectroscopy measurements with electrical simulation to reveal transepithelial barrier function and tissue structure of human intestinal epithelium cultured inside an organ-on-chip microfluidic cultur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa1098ff273db3f59a51a86bf38619e
https://pubmed.ncbi.nlm.nih.gov/30632575
https://pubmed.ncbi.nlm.nih.gov/30632575
Autor:
Karel Domansky, Geraldine A. Hamilton, Daniel Levner, Tiama Hamkins-Indik, Donald E. Ingber, Christopher David Hinojosa, Josiah Sliz, Guy Robert Thompson, Jacob P. Fraser, Norman Wen
Publikováno v:
Microfluidics and Nanofluidics. 21
The majority of microfluidic devices used for cell culture, including Organ-on-a-Chips (Organ Chips), are fabricated using polydimethylsiloxane (PDMS) polymer because it is flexible, optically clear, and easy to mold. However, PDMS possesses signific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78b19f036aab13ba31a571a23dd96a4d
https://doi.org/10.1007/s10404-017-1941-4
https://doi.org/10.1007/s10404-017-1941-4
Autor:
Remi Villenave, James C. Weaver, Samantha Q. Wales, Tiama Hamkins-Indik, Thomas C. Ferrante, Donald E. Ingber, Michael Kulka, Anthony Bahinski, Christopher A. Elkins, Efstathia Papafragkou
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 2, p e0169412 (2017)
PLoS ONE, Vol 12, Iss 2, p e0169412 (2017)
Analysis of enterovirus infection is difficult in animals because they express different virus receptors than humans, and static cell culture systems do not reproduce the physical complexity of the human intestinal epithelium. Here, using coxsackievi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875ca5a70c32567386b3e3b2c1489b14
https://pubmed.ncbi.nlm.nih.gov/28146569
https://pubmed.ncbi.nlm.nih.gov/28146569
Autor:
Anthony Bahinski, Josiah Sliz, Tiama Hamkins-Indik, Daniel C. Leslie, James McKinney, Jacob P. Fraser, Donald E. Ingber, Karel Domansky, Geraldine A. Hamilton
Publikováno v:
Lab on a Chip. 13:3956
Polydimethylsiloxane (PDMS) has numerous desirable properties for fabricating microfluidic devices, including optical transparency, flexibility, biocompatibility, and fabrication by casting; however, partitioning of small hydrophobic molecules into t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a0b7eb55b5d6fbce291035245f5d8e
https://doi.org/10.1039/c3lc50558h
https://doi.org/10.1039/c3lc50558h