Výsledky vyhledávání - "Tiago da Silva Medina"

Akademický článek

Comprehensive analysis of epigenetics regulation, prognostic and the correlation with immune infiltrates of GPX7 in adult gliomas

Autor: Wallax Augusto Silva Ferreira, Glauco Akelinghton Freire Vitiello, Tiago da Silva Medina, Edivaldo Herculano Correa de Oliveira

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-24 (2022)

Abstract Gliomas are the most commonly occurring malignant brain tumor characterized by an immunosuppressive microenvironment accompanied by profound epigenetic changes, thus influencing the prognosis. Glutathione peroxidase 7 (GPX7) is essential for

Externí odkaz: https://doaj.org/article/e39995896bdc4d46b1dcda88c6d07609

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Akademický článek

Antiviral Responses in Cancer: Boosting Antitumor Immunity Through Activation of Interferon Pathway in the Tumor Microenvironment

Autor: Glauco Akelinghton Freire Vitiello, Wallax Augusto Silva Ferreira, Vladmir Cláudio Cordeiro de Lima, Tiago da Silva Medina

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

In recent years, it became apparent that cancers either associated with viral infections or aberrantly expressing endogenous retroviral elements (EREs) are more immunogenic, exhibiting an intense intra-tumor immune cell infiltration characterized by

Externí odkaz: https://doaj.org/article/3427a3d049fa4ac3a23b500560336100

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Akademický článek

B Cell Orchestration of Anti-tumor Immune Responses: A Matter of Cell Localization and Communication

Autor: Gabriela Sarti Kinker, Glauco Akelinghton Freire Vitiello, Wallax Augusto Silva Ferreira, Alexandre Silva Chaves, Vladmir Cláudio Cordeiro de Lima, Tiago da Silva Medina

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

The immune system plays a crucial role in cancer development either by fostering tumor growth or destroying tumor cells, which has open new avenues for cancer immunotherapy. It was only over the last decade that the role of B cells in controlling ant

Externí odkaz: https://doaj.org/article/0d0a1bded21a4769a2d0c65e73f38275

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Akademický článek

Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells

Autor: Evelyne Lima-Fernandes, Alex Murison, Tiago da Silva Medina, Yadong Wang, Anqi Ma, Cherry Leung, Genna M. Luciani, Jennifer Haynes, Aaron Pollett, Constanze Zeller, Shili Duan, Antonija Kreso, Dalia Barsyte-Lovejoy, Bradly G. Wouters, Jian Jin, Daniel D. De Carvalho, Mathieu Lupien, Cheryl H. Arrowsmith, Catherine A. O’Brien

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

The presence of bivalent epigenetic active and repressive histone marks control lineage-specific differentiation in embryonic stem cells. Here, the authors reveal that bivalent marks repress the differentiation gene IHH in colorectal cancer-initiatin

Externí odkaz: https://doaj.org/article/03a72eb189654119bb1c127366a2d06f

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Dissertation/ Thesis

Participação do eixo Th17/IL-27 no controle da infecção experimental com Trypanosoma cruzi

Autor: Tiago da Silva Medina

Publikováno v: Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.

Produzida por macrófagos e células dendríticas, a IL-27 é uma citocina heterodimérica capaz de induzir células Tr1 produtoras de IL-10 e consequentemente regular linfócitos Th1, Th2 e Th17, dependendo da doença envolvida. Partindo-se do press

Externí odkaz: http://www.teses.usp.br/teses/disponiveis/17/17147/tde-02052014-160055/

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Mature tertiary lymphoid structures are key niches of tumour-specific immune responses in pancreatic ductal adenocarcinomas

Publikováno v: Gut. :gutjnl-2022

ObjectiveTo better understand the immune microenvironment of pancreatic ductal adenocarcinomas (PDACs), here we explored the relevance of T and B cell compartmentalisation into tertiary lymphoid structures (TLSs) for the generation of local antitumou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2c3970c7ae2047540e8f48f8e9c3c89
https://doi.org/10.1136/gutjnl-2022-328697

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Immune Checkpoint Blockade via PD-L1 Potentiates More CD28-Based than 4-1BB-Based Anti-Carbonic Anhydrase IX Chimeric Antigen Receptor T Cells

Autor: Najla Santos Pacheco de Campos, Adriano de Oliveira Beserra, Pedro Henrique Barbosa Pereira, Alexandre Silva Chaves, Fernando Luiz Affonso Fonseca, Tiago da Silva Medina, Tiago Goss dos Santos, Yufei Wang, Wayne Anthony Marasco, Eloah Rabello Suarez

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 10; Pages: 5448

The complete regression of clear cell renal cell carcinoma (ccRCC) obtained pre-clinically with anti-carbonic anhydrase IX (CAIX) G36 chimeric antigen receptor (CAR) T cells in doses equivalent to ≅108 CAR T cells/kg renewed the potential of this t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::212cf0044f1fa9b0b77b0994d9048ab2
https://pubmed.ncbi.nlm.nih.gov/35628256

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Genomic and Transcriptomic Characterization of the New Human Glioblastoma Cell Line AHOL1

Autor: Edivaldo Herculano Corrêa de Oliveira, Carolina Koury Nassar Amorim, Wallax Augusto Silva Ferreira, Fabio Albuquerque Machi, Tiago da Silva Medina, Rolando A R Villacis, Rommel Rodríguez Burbano

Cancer cell lines are widely used as in vitro models of tumorigenesis, facilitating fundamental discoveries in cancer biology and translational medicine. Currently, there are few options for glioblastoma (GBM) treatment and limited in vitro models wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6efc752cbf368a3839d1ca9ca3c811b
https://doi.org/10.20944/preprints201908.0288.v1