Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tiago Veltri"'
Autor:
Tiago Veltri, Guilherme A. P. de Oliveira, Ewa A. Bienkiewicz, Fernando L. Palhano, Mayra de A. Marques, Adolfo H. Moraes, Jerson L. Silva, Martha M. Sorenson, Jose R. Pinto
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The hypertrophic cardiomyopathy-associated mutant D145E, in cardiac troponin C (cTnC) C-domain, causes generalised instability at multiple sites in the isolated protein. As a result, structure and function of the mutant are more susceptible
Externí odkaz:
https://doaj.org/article/24f869ff88314b1487e847a605d31809
Autor:
Jose R. Pinto, Tiago Veltri, Maicon Landim-Vieira, Michelle S. Parvatiyar, David Gonzalez-Martinez, Karissa M. Dieseldorff Jones, Clara A. Michell, David Dweck, Andrew P. Landstrom, P. Bryant Chase
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Mutations in TNNC1—the gene encoding cardiac troponin C (cTnC)—that have been associated with hypertrophic cardiomyopathy (HCM) and cardiac dysfunction may also affect Ca2+-regulation and function of slow skeletal muscle since the same gene is ex
Externí odkaz:
https://doaj.org/article/de0f01d82986440e8a1a28beedc74a76
Autor:
David Gonzalez-Martinez, Karissa M. Dieseldorff Jones, Maicon Landim-Vieira, Michelle S. Parvatiyar, Jose R. Pinto, Andrew P. Landstrom, P. Bryant Chase, Clara A. Michell, Tiago Veltri, David Dweck
Publikováno v:
Frontiers in Physiology
Frontiers in Physiology, Vol 8 (2017)
Frontiers in Physiology, Vol 8 (2017)
Mutations in TNNC1—the gene encoding cardiac troponin C (cTnC)—that have been associated with hypertrophic cardiomyopathy (HCM) and cardiac dysfunction may also affect Ca2+-regulation and function of slow skeletal muscle since the same gene is ex
Autor:
Hyun Seok Hwang, Franz J. Baudenbacher, Jose R. Pinto, Tiago Veltri, Bjorn C. Knollmann, Raghav Venkataraman, Marcelo Perim Baldo
Publikováno v:
Journal of Molecular and Cellular Cardiology. 60:8-15
Myocardial infarction (MI) is a major risk for ventricular arrhythmia. Pause-triggered ventricular arrhythmia can be caused by increased myofilament Ca binding due to sarcomeric mutations or Ca-sensitizing compounds. Myofilament Ca sensitivity is als
Autor:
Tiago, Veltri, Guilherme A P, de Oliveira, Ewa A, Bienkiewicz, Fernando L, Palhano, Mayra de A, Marques, Adolfo H, Moraes, Jerson L, Silva, Martha M, Sorenson, Jose R, Pinto
Publikováno v:
Scientific Reports
The hypertrophic cardiomyopathy-associated mutant D145E, in cardiac troponin C (cTnC) C-domain, causes generalised instability at multiple sites in the isolated protein. As a result, structure and function of the mutant are more susceptible to higher
Publikováno v:
Biophysical Journal. 108(2):593a-594a
Mutations in cardiac troponin C (cTnC) have been linked to hypertrophic cardiomyopathy (HCM) in humans. The cTnC subunit of the troponin complex is expressed in both slow skeletal and cardiac muscle. The cTnC HCM mutations A8V, C84Y and D145E increas
Publikováno v:
Pflugers Archiv : European journal of physiology. 456(6)
In vertebrate skeletal muscle, the C-domain of troponin C (TnC) serves as an anchor; the N-domain regulates the position of troponin-tropomyosin on the thin filament after changes in intracellular Ca2+. Another type of thin-filament regulation is pro
Publikováno v:
Biophysical Journal. 104(2):449a-450a
We have shown previously that the hypertrophic cardiomyopathy mutant HcTnC D145E lacks α-helical content compared to WT and confers greater Ca2+ sensitivity on regulated thin filaments at 21°C. We hypothesize that the functional alterations are cau
Autor:
Marcelo Perim Baldo, Raghav Venkataraman, Bjorn C. Knollmann, Franz J. Baudenbacher, Tiago Veltri, M.A. Marschner, Hyun-Seok Hwang, Jose R. Pinto
Publikováno v:
Heart Rhythm. 9:1915
Background We recently demonstrated that pharmacologic Ca 2+ sensitization increased postpause ventricular tachycardia (VT) in the setting of acute myocardial infarction (MI). Similarly, chronic infarcted hearts show increased myofilament Ca 2+ sensi