Self-Hybridization in Leishmania major

Autor: Tiago R. Ferreira, Ehud Inbar, Jahangheer Shaik, Brendan M. Jeffrey, Kashinath Ghosh, Deborah E. Dobson, Stephen M. Beverley, David Sacks

Publikováno v: mBio, Vol 13, Iss 6 (2022)

ABSTRACT Genetic exchange between different Leishmania strains in the sand fly vector has been experimentally demonstrated and is supported by population genetic studies. In nature, opportunities for Leishmania interstrain mating are restricted to fl

Externí odkaz: https://doaj.org/article/e411654cf8044b90ba50e2c8e4780d56

Experimental Hybridization in

Autor: Tiago R, Ferreira, David L, Sacks

Publikováno v: Pathogens (Basel, Switzerland). 11(5)

Despite major advances over the last decade in our understanding of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::18bf670b6114c98a17da59c39389d4fa
https://pubmed.ncbi.nlm.nih.gov/35631101

Functional study ofLeishmania braziliensisprotein arginine methyltransferases (PRMTs) reveals that PRMT1 and PRMT5 are required for macrophage infection

Autor: J. Alcoforado Diniz, Tiago R. Ferreira, Lucas B. Lorenzon, Rubens Daniel Miserani Magalhães, Flávio Protaso Veras, G. D. Campagnaro, Luiz Gustavo de Almeida, José C. Quilles, Angela K. Cruz

In trypanosomatids, regulation of gene expression occurs mainly at the posttranscriptional level, and RNA-binding proteins (RBPs) are key players in determining the fates of transcripts. RBPs are major targets of protein arginine methyltransferases (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d9b314863a79ba7819f770efc7444c2
https://doi.org/10.1101/2021.09.22.461376

Differential Gene Expression and Infection Profiles of Cutaneous and Mucosal Leishmania braziliensis Isolates from the Same Patient.

Autor: Eliza V C Alves-Ferreira, Juliano S Toledo, Arthur H C De Oliveira, Tiago R Ferreira, Patricia C Ruy, Camila F Pinzan, Ramon F Santos, Viviane Boaventura, David Rojo, Ángelez López-Gonzálvez, Jose C Rosa, Coral Barbas, Manoel Barral-Netto, Aldina Barral, Angela K Cruz

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 9, p e0004018 (2015)

Leishmaniasis is a complex disease in which clinical outcome depends on factors such as parasite species, host genetics and immunity and vector species. In Brazil, Leishmania (Viannia) braziliensis is a major etiological agent of cutaneous (CL) and m

Externí odkaz: https://doaj.org/article/dbb7bfe6f6ac4a3b9e56b7ede247314e

Protein methyltransferase 7 deficiency in Leishmania major increases neutrophil associated pathology in murine model

Autor: Rafael Ricci-Azevedo, Mariana M. Chaves, Dario S. Zamboni, Rubens Daniel Miserani Magalhães, Tiago R. Ferreira, Pegine B. Walrad, Renan V. H. de Carvalho, David L. Sacks, Slavica Vaselek, Angela K. Cruz, Juliana Alcoforado Diniz, Lucas B. Lorenzon, Petr Volf

Publikováno v: PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009230 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS Neglected Tropical Diseases
PLOS Neglected Tropical Diseases

Leishmania major is the main causative agent of cutaneous leishmaniasis in the Old World. In Leishmania parasites, the lack of transcriptional control is mostly compensated by post-transcriptional mechanisms. Methylation of arginine is a conserved po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19cb51e29b2c50b89620c84d3976760
https://doaj.org/article/fc6c456a480446dd8f8cc9b8f8b6c3d8