Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Tiago R. D. Costa"'
Autor:
Lingchen He, Laura Miguel-Romero, Jonasz B. Patkowski, Nasser Alqurainy, Eduardo P. C. Rocha, Tiago R. D. Costa, Alfred Fillol-Salom, José R. Penadés
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Many bacterial immune systems recognize phage structural components to activate antiviral responses, without inhibiting the function of the phage component. These systems can be encoded in specific chromosomal loci, known as defense islands,
Externí odkaz:
https://doaj.org/article/b98ef47ae13041da90e6cd058eed4d51
Autor:
Selina Fecht, Patricia Paracuellos, Sujatha Subramoni, Casandra Ai Zhu Tan, Aravindan Ilangovan, Tiago R. D. Costa, Alain Filloux
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The genome of Pseudomonas aeruginosa encodes three type VI secretion systems, each comprising a dozen distinct proteins, which deliver toxins upon T6SS sheath contraction. The least conserved T6SS component, TssA, has variations in size whic
Externí odkaz:
https://doaj.org/article/3abfa31a14b442cfb7b894626719e8d1
Autor:
Leticia Beltrán, Holly Torsilieri, Jonasz B. Patkowski, Jie E. Yang, James Casanova, Tiago R. D. Costa, Elizabeth R. Wright, Edward H. Egelman
Publikováno v:
mBio, Vol 15, Iss 1 (2024)
ABSTRACTBacterial conjugation, a process of horizontal gene transfer, plays a key role in promoting the spread of antimicrobial resistance among human pathogens. The mechanism of conjugation involves the development of a conjugative pilus that forms
Externí odkaz:
https://doaj.org/article/dfd06a30b5de4601a4a96aec04185cba
Autor:
Jonasz B. Patkowski, Tobias Dahlberg, Himani Amin, Dharmender K. Gahlot, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Matthew S. Francis, Joseph L. Baker, Magnus Andersson, Tiago R. D. Costa
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Enteropathogenic bacteria use extracellular appendages, known as F-pili, to share plasmids carrying antibiotic resistance genes. Here, the authors show that F-pili are highly flexible but robust at the same time, and this is important for plasmid tra
Externí odkaz:
https://doaj.org/article/40e85687bf8846788a5af8d328f2c24c
Autor:
Leticia C. Beltran, Virginija Cvirkaite-Krupovic, Jessalyn Miller, Fengbin Wang, Mark A. B. Kreutzberger, Jonasz B. Patkowski, Tiago R. D. Costa, Stefan Schouten, Ilya Levental, Vincent P. Conticello, Edward H. Egelman, Mart Krupovic
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Bacteria can exchange DNA through extracellular appendages (‘mating pili’) in a process known as conjugation. Here, Beltran et al. determine atomic structures by cryo-electron microscopy of a bacterial conjugative pilus and two archaeal pili, sho
Externí odkaz:
https://doaj.org/article/44686fdde37848d3a4f975953dcdb8dc
Autor:
Mark A. B. Kreutzberger, Richard C. Sobe, Amber B. Sauder, Sharanya Chatterjee, Alejandro Peña, Fengbin Wang, Jorge A. Giron, Volker Kiessling, Tiago R. D. Costa, Vincent P. Conticello, Gad Frankel, Melissa M. Kendall, Birgit E. Scharf, Edward H. Egelman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
It has been suggested that the outer domains of bacterial flagellins are not needed for motility. Here, the authors show that flagellar filament outer domains from some bacteria have unique structures which can alter the motility of the bacteria.
Externí odkaz:
https://doaj.org/article/675e18c006ad4e0d88a5c2700432e60a
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
DNA transfer between two bacterial cells is mediated by the conjugative type 4 secretion systems (T4SSs). Here, the authors report the structure of a complete T4SS outer-membrane core complex (OMCC), revealing distinct C17 and C13 symmetries of its c
Externí odkaz:
https://doaj.org/article/456d0a88e2384a64a1736735fb2b99ba
Autor:
Sophie A. Howard, R. Christopher D. Furniss, Dora Bonini, Himani Amin, Patricia Paracuellos, David Zlotkin, Tiago R. D. Costa, Asaf Levy, Despoina A. I. Mavridou, Alain Filloux
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
The type VI secretion system (T6SS) is an effective weapon used by bacteria to outgrow or kill competitors. It can be used by endogenous commensal microbiota to prevent invasion by pathogens or by pathogens to overcome resident flora and successfully
Externí odkaz:
https://doaj.org/article/322b63a02dfb4f6ebaeafe023cfa58cf
Autor:
Allison H. Williams, Adam Redzej, Nathalie Rolhion, Tiago R. D. Costa, Aline Rifflet, Gabriel Waksman, Pascale Cossart
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The bacterial stressosome is a large nanomachine and a key inducer of stress response. Here, the authors present the cryo-EM structure of the stressosome from the bacterial pathogen Listeria monocytogenes at 3.38 Å resolution and discuss its activat
Externí odkaz:
https://doaj.org/article/1a99182087754942bc951b83e22f5f47
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/d3abf49b456b425486e64e8f884268c4