Cladribine Treatment for MS Preserves the Differentiative Capacity of Subsequently Generated Monocytes, Whereas Its Administration In Vitro Acutely Influences Monocyte Differentiation but Not Microglial Activation

Autor: Tiago Medeiros-Furquim, Sinan Ayoub, Laura J. Johnson, Andrea Aprico, Eze Nwoke, Michele D. Binder, Trevor J. Kilpatrick

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Cladribine (2-chlorodeoxyadenosine, 2CdA) is one of the most effective disease-modifying drugs for multiple sclerosis (MS). Cladribine is a synthetic purine nucleoside analog that induces cell death of lymphocytes and oral cladribine treatment leads

Externí odkaz: https://doaj.org/article/94ed270034be42b9873adc2296416d2a

VISTA regulates microglia homeostasis and myelin phagocytosis, and is associated with MS lesion pathology

Autor: Sam W. Lee, Fenja L. Gierschek, Susanne M. Kooistra, Randolph J. Noelle, Maaike L. Brummer, Tiago Medeiros-Furquim, Bart J. L. Eggen, Malte Borggrewe, Tegan A. Otto, Elizabeth C. Nowak, Evelyn Wesseling, Jon D. Laman

Publikováno v: Acta neuropathologica communications, 9(1):91, 91-109. BioMed Central Ltd.
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)

V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA) is a negative checkpoint regulator (NCR) that is involved in T-cell quiescence, inhibition of T-cell activation, and in myeloid cells regulates cytokine production, chemo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce58e84545a9db811d42f63609c1b58
https://research.rug.nl/en/publications/ac4daf39-ce9b-44b1-b26f-012beb8cb19a

Transcriptomic and epigenomic landscapes of Alzheimer's disease evidence mitochondrial-related pathways

Autor: Alejandro Marmolejo-Garza, Tiago Medeiros-Furquim, Ramya Rao, Bart J.L. Eggen, Erik Boddeke, Amalia M. Dolga

Publikováno v: Marmolejo-Garza, A, Medeiros-Furquim, T, Rao, R, Eggen, B J L, Boddeke, E & Dolga, A M 2022, ' Transcriptomic and epigenomic landscapes of Alzheimer's disease evidence mitochondrial-related pathways ', Biochimica et Biophysica Acta-Molecular Cell Research, vol. 1869, no. 10, 119326 . https://doi.org/10.1016/j.bbamcr.2022.119326

Alzheimer's Disease (AD) is the main cause of dementia and it is defined by cognitive decline coupled to extracellular deposit of amyloid-beta protein and intracellular hyperphosphorylation of tau protein. Historically, efforts to target such hallmar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904b01ee270533cf119457cc880bd55e
https://pubmed.ncbi.nlm.nih.gov/35839870

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