Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Tiago L Duarte"'
Autor:
Sarah K Wideman, Joe N Frost, Felix C Richter, Caitlin Naylor, José M Lopes, Nicole Viveiros, Megan R Teh, Alexandra E Preston, Natasha White, Shamsideen Yusuf, Simon J Draper, Andrew E Armitage, Tiago L Duarte, Hal Drakesmith
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011679 (2023)
Malaria and iron deficiency are major global health problems with extensive epidemiological overlap. Iron deficiency-induced anaemia can protect the host from malaria by limiting parasite growth. On the other hand, iron deficiency can significantly d
Externí odkaz:
https://doaj.org/article/582690d7c2874b0f9da71e246c411f20
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Heme is essential for a variety of proteins involved in vital physiological functions in the body, such as oxygen transport, drug metabolism, biosynthesis of steroids, signal transduction, antioxidant defense and mitochondrial respiration. However, f
Externí odkaz:
https://doaj.org/article/57fd6ad2d70f497a9a3336f9436ba5ea
Autor:
Maria P. Coutinho, Maria José Teles, Graça Melo, Marta Lopes, Delfim Duarte, Tiago L. Duarte, Júlia Reis, Ana Cláudia Martins, José Carlos Oliveira, Graça Porto
Publikováno v:
HemaSphere, Vol 6, Iss 9, p e770 (2022)
Externí odkaz:
https://doaj.org/article/32c3b68fa8594178bd76f8e96911ad40
Autor:
Sant-Rayn Pasricha, Pei Jin Lim, Tiago L. Duarte, Carla Casu, Dorenda Oosterhuis, Katarzyna Mleczko-Sanecka, Maria Suciu, Ana Rita Da Silva, Kinda Al-Hourani, João Arezes, Kirsty McHugh, Sarah Gooding, Joe N. Frost, Katherine Wray, Ana Santos, Graça Porto, Emmanouela Repapi, Nicki Gray, Simon J. Draper, Neil Ashley, Elizabeth Soilleux, Peter Olinga, Martina U. Muckenthaler, Jim R. Hughes, Stefano Rivella, Thomas A. Milne, Andrew E. Armitage, Hal Drakesmith
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling. Here, Pasricha et al. demonstrate that the hepcidin-chromatin locus displays HDAC3-mediated reversible epigenetic modifications during both erythropoi
Externí odkaz:
https://doaj.org/article/15032712babd4934b8cf9987f86cc0ba
Autor:
Tiago L. Duarte, Carolina Caldas, Ana G. Santos, Sandro Silva-Gomes, Andreia Santos-Gonçalves, Maria João Martins, Graça Porto, José Manuel Lopes
Publikováno v:
Redox Biology, Vol 11, Iss , Pp 157-169 (2017)
Background and Aims: In hereditary hemochromatosis, iron deposition in the liver parenchyma may lead to fibrosis, cirrhosis and hepatocellular carcinoma. Most cases are ascribed to a common mutation in the HFE gene, but the extent of clinical express
Externí odkaz:
https://doaj.org/article/da0e2e6188554f3d9b7b340b445adfa1
Autor:
Sarah K. Wideman, Joe N. Frost, Felix C. Richter, Caitlin Naylor, José M. Lopes, Nicole Viveiros, Megan R. Teh, Alexandra E. Preston, Natasha White, Shamsideen Yusuf, Simon J. Draper, Andrew E. Armitage, Tiago L. Duarte, Hal Drakesmith
Malaria and iron deficiency are major global health problems with extensive epidemiological overlap. Iron deficiency-induced anaemia can protect the host from malaria by limiting parasite growth. On the other hand, iron deficiency can significantly d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f2b46addcbc006cd3dcddfb86e7f613
https://doi.org/10.1101/2023.02.05.527208
https://doi.org/10.1101/2023.02.05.527208
Publikováno v:
Antioxidants & Redox Signaling. 35:433-452
Significance: Oxygen metabolism and iron homeostasis are closely linked. Iron facilitates the oxygen-carrying capacity of blood, and its deficiency causes anaemia. Conversely, excess free iron is detrimental for stimulating the formation of reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546e89932c55539a5e7a4f9eee613101
https://doi.org/10.1089/ars.2020.8148
https://doi.org/10.1089/ars.2020.8148
Autor:
João V. Neves, Tiago L. Duarte
Publikováno v:
Journal of Visualized Experiments.
Iron is an essential micronutrient. Both iron overload and deficiency are highly detrimental to humans, and tissue iron levels are finely regulated. The use of experimental animal models of iron overload or deficiency has been instrumental to advance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8e982c6be858e59e23dde31475474c
https://doi.org/10.3791/63469
https://doi.org/10.3791/63469
Autor:
Isabella Y. Kong, Tiago L. Duarte, Edwin D. Hawkins, João Tiago Guimarães, Miguel Quintela, Maria José Teles, Magnus Zethoven, Graça Porto, Jose Mario Mariz, Sérgio Chacim, Fernanda Trigo, Joana Pereira-Reis, Stephin J. Vervoort, Delfim Duarte, André M. N. Silva, Monica Oliveira, Nuno Pina Gonçalves, Laura Mosteo, Marta Lopes, Eliana Aguiar, Sandra Martins, Gabriela Martins
Publikováno v:
Blood Adv
Acute myeloid leukemia (AML) is a heterogeneous disease with poor prognosis and limited treatment strategies. Determining the role of cell-extrinsic regulators of leukemic cells is vital to gain clinical insights into the biology of AML. Iron is a ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f90b9660b731e0662663029e723374
https://europepmc.org/articles/PMC8405200/
https://europepmc.org/articles/PMC8405200/
Autor:
Tiago L. Duarte, S. Marques, T. dos Santos, Aroldo Ferreira, Pedro L. Granja, Sara C. Neves, Graça Porto, Paulo Costa
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 3, Iss 2, Pp 100145-(2021)
Objective Arthropathy is a major clinical problem in patients with hemochromatosis, the most common genetic disorder of iron overload. The pathological features of hemochromatosis arthropathy (HA) are heterogeneous and its specific nature remains unk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9db04f6d37d2adbb724cab0ed5995d
http://www.sciencedirect.com/science/article/pii/S266591312100008X
http://www.sciencedirect.com/science/article/pii/S266591312100008X