Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Tiago Gil Oliveira"'
Autor:
Francisco C. Almeida, Kalicharan Patra, Andreas Giannisis, Anezka Niesnerova, Renu Nandakumar, Ewa Ellis, Tiago Gil Oliveira, Henrietta M. Nielsen
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 2, Pp 100498- (2024)
Apolipoprotein E (APOE) genetic variants are most notably known for their divergent impact on the risk of developing Alzheimer’s disease. While APOE genotype has been consistently shown to modulate lipid metabolism in a variety of cellular contexts
Externí odkaz:
https://doaj.org/article/6e9b1fd161db4abdbe48aee81b71f33b
Autor:
André Miguel Miranda, Archana Ashok, Robin Barry Chan, Bowen Zhou, Yimeng Xu, Laura Beth McIntire, Estela Area-Gomez, Gilbert Di Paolo, Karen E. Duff, Tiago Gil Oliveira, Tal Nuriel
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Apolipoprotein E ε4 (APOE4) is the primary genetic risk factor for the late-onset form of Alzheimer’s disease (AD). Although the reason for this association is not completely understood, researchers have uncovered numerous effects of APOE
Externí odkaz:
https://doaj.org/article/1b664e375f334e4581d06cefe755b424
Autor:
João Pedro Ferreira, Adelino Leite-Moreira, Altamiro da Costa-Pereira, António José Soares, Carlos Robalo-Cordeiro, Cármen Jerónimo, Cristina Gavina, Fausto J. Pinto, Fernando Schmitt, Francisca Saraiva, Francisco Vasques-Nóvoa, Helena Canhão, Henrique Cyrne-Carvalho, Isabel Palmeirim, Joana Pimenta, João Eurico Cabral da Fonseca, João Firmino-Machado, Jorge Correia Pinto, Lino, Miguel Castelo Branco, Nuno Sousa, Ricardo Fontes de Carvalho, Teresa Machado Luciano, Tiago Gil Oliveira, Catarina Resende Oliveira
Publikováno v:
Acta Médica Portuguesa (2023)
N/a.
Externí odkaz:
https://doaj.org/article/f91dc283446748e396ed0ffcbf23434e
Publikováno v:
International Archives of Otorhinolaryngology, Vol 26, Iss 03, Pp e296-e303 (2022)
Introduction Idiopathic sudden sensorineural hearing loss (ISSHL) is a disabling otologic urgency whose ethiopathogenesis is still controversial. Only in recent years metabolic syndrome (MetS) has been implicated as a possible aggravating factor in t
Externí odkaz:
https://doaj.org/article/49eac9a29acc4c768a786abecfd004b5
Autor:
João Pinho, José Manuel Araújo, Ana Sofia Costa, Fátima Silva, Alexandra Francisco, Miguel Quintas-Neves, João Soares-Fernandes, Carla Ferreira, Tiago Gil Oliveira
Publikováno v:
Cerebrovascular Diseases Extra, Vol 11, Iss 1, Pp 15-21 (2021)
Background: Intracerebral hemorrhage (ICH) recurrence risk is known to be higher in patients with cerebral amyloid angiopathy (CAA) as compared to other causes of ICH. Risk factors for ICH recurrence are not completely understood, and our goal was to
Externí odkaz:
https://doaj.org/article/cbb532e3535845339637d731c844dd30
Autor:
Miguel Quintas-Neves, Merilee A. Teylan, Lilah Besser, João Soares-Fernandes, Charles N. Mock, Walter A. Kukull, John F. Crary, Tiago Gil Oliveira
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-9 (2019)
Abstract Alzheimer disease (AD) is a neurodegenerative disorder characterized pathologically by the accumulation of amyloid-beta (Aβ) plaques and tau neurofibrillary tangles (NFTs). Recently, primary age-related tauopathy (PART) has been described a
Externí odkaz:
https://doaj.org/article/339702ece552480686b6b2fb16d02492
Autor:
Luísa Santa-Marinha, Isabel Castanho, Rita Ribeiro Silva, Francisca Vaz Bravo, André Miguel Miranda, Torcato Meira, Rafaela Morais-Ribeiro, Fernanda Marques, Yimeng Xu, Kimberly Point du Jour, Markus Wenk, Robin Barry Chan, Gilbert Di Paolo, Vítor Pinto, Tiago Gil Oliveira
Publikováno v:
Cell Reports, Vol 30, Iss 12, Pp 4197-4208.e6 (2020)
Summary: Phosphatidic acid (PA) is a signaling lipid involved in the modulation of synaptic structure and functioning. Based on previous work showing a decreasing PA gradient along the longitudinal axis of the rodent hippocampus, we asked whether the
Externí odkaz:
https://doaj.org/article/f1f21573562f4a339d1161bbd04a7040
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0235609 (2020)
Soccer is the most popular sport in the world and, since it is a contact sport, players are at risk for head injury, including concussion. Here, we proposed to investigate the association of heading and concussion with macroscopic brain structure amo
Externí odkaz:
https://doaj.org/article/303f047a4abb40a48fcf8fad36cf8d19
Autor:
Francisca Vaz Bravo, Jorge Da Silva, Robin Barry Chan, Gilbert Di Paolo, Andreia Teixeira-Castro, Tiago Gil Oliveira
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Phospholipase D (PLD) is a key player in the modulation of multiple aspects of cell physiology and has been proposed as a therapeutic target for Alzheimer’s disease (AD). Here, we characterize a PLD mutant, pld-1, using the Caenorhabditis
Externí odkaz:
https://doaj.org/article/adc50c1c0cbe438192dca4a769e19623
Autor:
André M. Miranda, Zofia M. Lasiecka, Yimeng Xu, Jessi Neufeld, Sanjid Shahriar, Sabrina Simoes, Robin B. Chan, Tiago Gil Oliveira, Scott A. Small, Gilbert Di Paolo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Neurodegeneration is increasingly associated with endolysosomal and autophagy dysfunction. Here, Miranda and colleagues show that disruption of neuronal PI3P/Vps34 signaling leads to endolysosomal membrane damage and aberrant release of undigested ma
Externí odkaz:
https://doaj.org/article/86b0425ec6574642a7fb5c502f85d7c0