Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Tiago Fernandes da Silva"'
Autor:
Dahara Keyse Carvalho Silva, Jessicada Silva Teixeira, Diogo Rodrigo Magalhães Moreira, Tiago Fernandes da Silva, Eliezer Jesus de Lacerda Barreiro, Humberto Fonseca de Freitas, Samuel Silva da Rocha Pita, André Lacerda Braga Teles, Elisalva Teixeira Guimarães, Milena Botelho Pereira Soares
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Leishmaniasis are group of neglected diseases with worldwide distribution that affect about 12 million people. The current treatment is limited and may cause severe adverse effects, and thus, the search for new drugs more effective and less toxic is
Externí odkaz:
https://doaj.org/article/a493384d315248e180d966857d091279
Autor:
Lidia Moreira Lima, Tiago Fernandes da Silva, Carlos Eduardo da Silva Monteiro, Cristiane Aparecida-Silva, Walfrido Bispo Júnior, Aline Cavalcanti de Queiroz, Magna Suzana Alexandre-Moreira, Gisele Zapata-Sudo, Eliezer J. Barreiro
Publikováno v:
Molecules, Vol 26, Iss 16, p 4828 (2021)
Acylhydrazones are still an important framework to the design of new bioactive compounds. As treatment of chronic pain represents a clinical challenge, we decided to modify the structure of LASSBio-1514 (1), previously described as anti-inflammatory
Externí odkaz:
https://doaj.org/article/c0a533780ffc4ea1a2d6a027150272ec
Autor:
Tiago Fernandes da Silva, Walfrido Bispo Júnior, Magna Suzana Alexandre-Moreira, Fanny Nascimento Costa, Carlos Eduardo da Silva Monteiro, Fabio Furlan Ferreira, Regina Cely Rodrigues Barroso, François Noël, Roberto Takashi Sudo, Gisele Zapata-Sudo, Lídia Moreira Lima, Eliezer J. Barreiro
Publikováno v:
Molecules, Vol 20, Iss 2, Pp 3067-3088 (2015)
The N-acylhydrazone (NAH) moiety is considered a privileged structure, being present in many compounds with diverse pharmacological activities. Among the activities attributed to NAH derivatives anti-inflammatory and analgesic ones are recurrent. As
Externí odkaz:
https://doaj.org/article/9c970d1079fe464481f83059551de8c1
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136761 (2015)
Pyridoxinamine 5'-phosphate oxidases (P(N/M)P oxidases) that bind flavin mononucleotide (FMN) and oxidize pyridoxine 5'-phosphate or pyridoxamine 5'-phosphate to form pyridoxal 5'-phosphate (PLP) are an important class of enzymes that play a central
Externí odkaz:
https://doaj.org/article/c45f960b4ca6442cb9b735918ebac440
Autor:
Magna Suzana Alexandre-Moreira, Carlos Eduardo da Silva Monteiro, Aline Cavalcanti de Queiroz, Eliezer J. Barreiro, Lídia Moreira Lima, Walfrido Bispo Júnior, Gisele Zapata-Sudo, Cristiane Aparecida-Silva, Tiago Fernandes da Silva
Publikováno v:
Molecules
Molecules, Vol 26, Iss 4828, p 4828 (2021)
Volume 26
Issue 16
Molecules, Vol 26, Iss 4828, p 4828 (2021)
Volume 26
Issue 16
Acylhydrazones are still an important framework to the design of new bioactive compounds. As treatment of chronic pain represents a clinical challenge, we decided to modify the structure of LASSBio-1514 (1), previously described as anti-inflammatory
Autor:
Elisalva Teixeira Guimarães, Eliezer J. Barreiro, Didier Salmon, Dahara Keyse Carvalho Silva, Tatiana B. dos Santos, Cássio Santana Meira, Diogo Rodrigo Magalhães Moreira, Milena Botelho Pereira Soares, Tiago Fernandes da Silva
Publikováno v:
International immunopharmacology. 65
Immunosuppressive drugs are widely used for the treatment of immune-mediated diseases and inflammation, but the toxicity and side effects of the available immunosuppressors make the search of new agents of great relevance. Here, we evaluated the immu
Autor:
Eliezer J. Barreiro, Fabio Furlan Ferreira, Francesco Punzo, Tiago Fernandes da Silva, Delson Braz, Lídia Moreira Lima, Fanny N. Costa, Eduardo Miguez Bastos da Silva, Regina C. Barroso
Publikováno v:
RSC Advances. 5:39889-39898
LASSBio-1601, a cyclohexyl-N-acylhydrazone derivative, was synthesized as part of a research program to develop a series of anti-inflammatory and analgesic compounds. A complete knowledge of the structure, including stereochemistry, is essential to l
Autor:
Delson Braz, Regina C. Barroso, Francesco Punzo, Eliezer J. Barreiro, Lídia Moreira Lima, Fabio Furlan Ferreira, Tiago Fernandes da Silva, Fanny N. Costa, Giuseppe Lombardo, Isadora T.S. Bastos
LASSBio-1755 is a new cycloalkyl-N-acylhydrazone parent compound designed for the development of derivatives with antinociceptive and anti-inflammatory activities. Although single crystal X-ray diffraction has been considered as the golden standard i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ebec9731ef34ff9981940e93e65872
https://hdl.handle.net/20.500.11769/321421
https://hdl.handle.net/20.500.11769/321421
Autor:
Regina C. Barroso, Fabio Furlan Ferreira, Tiago Fernandes da Silva, Lídia Moreira Lima, Fanny N. Costa, Delson Braz, Eliezer J. Barreiro
Publikováno v:
Powder Diffraction. 28:S491-S509
Many N-acylhydrazone derivatives synthetized in LASSBio® cannot be prepared as single crystals of sufficient size and/or quality for structure determination to be carried out using single crystal X-ray diffraction techniques. This article highlights