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Akademický článek

Mammalian embryo comparison identifies novel pluripotency genes associated with the naïve or primed state

Publikováno v: Biology Open, Vol 7, Iss 8 (2018)

During early mammalian development, transient pools of pluripotent cells emerge that can be immortalised upon stem cell derivation. The pluripotent state, ‘naïve’ or ‘primed’, depends on the embryonic stage and derivation conditions used. He

Externí odkaz: https://doaj.org/article/c7dcadce61d94f648a649a416ee01f36

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Akademický článek

In Vivo T-Box Transcription Factor Profiling Reveals Joint Regulation of Embryonic Neuromesodermal Bipotency

Autor: George E. Gentsch, Nick D.L. Owens, Stephen R. Martin, Paul Piccinelli, Tiago Faial, Matthew W.B. Trotter, Michael J. Gilchrist, James C. Smith

Publikováno v: Cell Reports, Vol 4, Iss 6, Pp 1185-1196 (2013)

The design of effective cell replacement therapies requires detailed knowledge of how embryonic stem cells form primary tissues, such as mesoderm or neurectoderm that later become skeletal muscle or nervous system. Members of the T-box transcription

Externí odkaz: https://doaj.org/article/c1461fc62025473da784aadbf45cc289

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Akademický článek

Genomic targets of Brachyury (T) in differentiating mouse embryonic stem cells.

Autor: Amanda L Evans, Tiago Faial, Michael J Gilchrist, Thomas Down, Ludovic Vallier, Roger A Pedersen, Fiona C Wardle, James C Smith

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e33346 (2012)

BackgroundThe T-box transcription factor Brachyury (T) is essential for formation of the posterior mesoderm and the notochord in vertebrate embryos. Work in the frog and the zebrafish has identified some direct genomic targets of Brachyury, but littl

Externí odkaz: https://doaj.org/article/21d739225a0f4ef7a5e245d45c078b9b

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