Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Tiago D. Serafim"'
Autor:
Anderson B. Guimaraes-Costa, John P. Shannon, Ingrid Waclawiak, Jullyanna Oliveira, Claudio Meneses, Waldione de Castro, Xi Wen, Joseph Brzostowski, Tiago D. Serafim, John F. Andersen, Heather D. Hickman, Shaden Kamhawi, Jesus G. Valenzuela, Fabiano Oliveira
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Immune mimicry has been shown in chemokine like moieties from bacteria and viruses. Here, the authors characterise a sand fly salivary protein that induces neutrophil chemotaxis and explore its impact in a model of parasitic infection.
Externí odkaz:
https://doaj.org/article/6c6f9032af8240ea805203e2fd59b3d5
Autor:
Pedro Cecílio, James Oristian, Claudio Meneses, Tiago D. Serafim, Jesus G. Valenzuela, Anabela Cordeiro da Silva, Fabiano Oliveira
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Abstract Leishmaniasis is a spectrum of diseases transmitted by sand fly vectors that deposit Leishmania spp. parasites in the host skin during blood feeding. Currently, available treatment options are limited, associated with high toxicity and emerg
Externí odkaz:
https://doaj.org/article/ebd49ccaad9d4970afc0c598e51f5cf8
Autor:
Wen-Wei Zhang, Subir Karmakar, Sreenivas Gannavaram, Ranadhir Dey, Patrick Lypaczewski, Nevien Ismail, Abid Siddiqui, Vahan Simonyan, Fabiano Oliveira, Iliano V. Coutinho-Abreu, Thiago DeSouza-Vieira, Claudio Meneses, James Oristian, Tiago D. Serafim, Abu Musa, Risa Nakamura, Noushin Saljoughian, Greta Volpedo, Monika Satoskar, Sanika Satoskar, Pradeep K. Dagur, J. Philip McCoy, Shaden Kamhawi, Jesus G. Valenzuela, Shinjiro Hamano, Abhay R. Satoskar, Greg Matlashewski, Hira L. Nakhasi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Here, the authors engineer an attenuated knock-out Leishmania (LmCen −/−) vaccine that is safe in immunocompromised mice and induces an immune response and protection similar to leishmanization with wild-type Leishmania. Since LmCen −/− is an
Externí odkaz:
https://doaj.org/article/a50605a064c049859dfcd1fb76a10dad
Autor:
Rajesh Garlapati, Eva Iniguez, Tiago D. Serafim, Prabhas K. Mishra, Basab Rooj, Bikas Sinha, Jesus G. Valenzuela, Sridhar Srikantiah, Caryn Bern, Shaden Kamhawi
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Visceral leishmaniasis (VL) is a potentially deadly parasitic disease. In the Indian sub-continent, VL is caused by Leishmania donovani and transmitted via the bite of an infected Phlebotomus argentipes female sand fly, the only competent vector spec
Externí odkaz:
https://doaj.org/article/8f82388cbc0242918a485f6f6aa50eb5
Autor:
Fernando Fernandez-Cortes, Tiago D. Serafim, Jonathan M. Wilkes, Nathaniel G. Jones, Ryan Ritchie, Richard McCulloch, Jeremy C. Mottram
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Protein kinases (PKs) are a class of druggable targets in Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (sleeping sickness), yet little is known about which PKs are essential for survival in mammals. A recent kinom
Externí odkaz:
https://doaj.org/article/f42ca3b4269e44a1a0bd4fab4c2527c1
Autor:
Patrick H. Kelly, Sarah M. Bahr, Tiago D. Serafim, Nadim J. Ajami, Joseph F. Petrosino, Claudio Meneses, John R. Kirby, Jesus G. Valenzuela, Shaden Kamhawi, Mary E. Wilson
Publikováno v:
mBio, Vol 8, Iss 1 (2017)
ABSTRACT The vector-borne disease leishmaniasis, caused by Leishmania species protozoa, is transmitted to humans by phlebotomine sand flies. Development of Leishmania to infective metacyclic promastigotes in the insect gut, a process termed metacyclo
Externí odkaz:
https://doaj.org/article/d6dd89872da046f8a1e1c0dc1b822334
Autor:
Eva Iniguez, Samiran Saha, Georgios Petrellis, Claudio Menenses, Samantha Herbert, Yvonne Gonzalez-Rangel, Tobin Rowland, Naomi E Aronson, Clair Rose, Lee Rafuse Haines, Alvaro Acosta-Serrano, Tiago D Serafim, Fabiano Oliveira, Sridhar Srikantiah, Caryn Bern, Jesus G Valenzuela, Shaden Kamhawi
Publikováno v:
The journal of infectious diseases
J Infect Dis
J Infect Dis
Incidence of visceral leishmaniasis (VL) in the Indian subcontinent (ISC) has declined by more than 95% since initiation of the elimination program in 2005. As the ISC transitions to the postelimination surveillance phase, an accurate measurement of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e18ab20f1141f51787dfec7bb35431
https://doi.org/10.1093/infdis/jiac354
https://doi.org/10.1093/infdis/jiac354
Autor:
Tiago D. Serafim, Eva Iniguez, Ana Beatriz F. Barletta, Johannes S.P. Doehl, Mara Short, Justin Lack, Pedro Cecilio, Vinod Nair, Maria Disotuar, Timothy Wilson, Iliano V. Coutinho-Abreu, Fabiano Oliveira, Claudio Meneses, Carolina Barillas-Mury, John Andersen, José M.C. Ribeiro, Stephen M. Beverley, Shaden Kamhawi, Jesus G.Valenzuela
Host factors mediating Leishmania genetic exchange are not well defined. Here, we demonstrate that IgM antibodies, but not IgG or IgA, facilitate parasite genetic hybridization in vitro and in vivo. IgM induces the gradual and transient formation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21329f91c586c419bf0b6137b6a2e12f
https://doi.org/10.1101/2022.06.09.495557
https://doi.org/10.1101/2022.06.09.495557
Autor:
Iliano V. Coutinho-Abreu, Fabiano Oliveira, Shaden Kamhawi, Claudio Meneses, Tiago D. Serafim, Jesus G. Valenzuela
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-16 (2020)
BMC Genomics
BMC Genomics
Background Sand flies are the vectors of Leishmania parasites. To develop in the sand fly midgut, Leishmania multiplies and undergoes various stage differentiations giving rise to the infective form, the metacyclic promastigotes. To determine the cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3e5892016880881399a868c361a853
http://link.springer.com/article/10.1186/s12864-020-07025-8
http://link.springer.com/article/10.1186/s12864-020-07025-8
Autor:
Abhay R. Satoskar, Greg Matlashewski, Greta Volpedo, J. Philip McCoy, Thiago DeSouza-Vieira, Jesus G. Valenzuela, Sreenivas Gannavaram, Fabiano Oliveira, Abid Siddiqui, Noushin Saljoughian, Nevien Ismail, Patrick Lypaczewski, Iliano V. Coutinho-Abreu, Sanika Satoskar, Claudio Meneses, Shaden Kamhawi, Vahan Simonyan, Subir Karmakar, Abu Musa, Wen Wei Zhang, James Oristian, Monika Satoskar, Shinjiro Hamano, Tiago D. Serafim, Risa Nakamura, Pradeep K. Dagur, Hira L. Nakhasi, Ranadhir Dey
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Leishmaniasis is a neglected tropical disease caused by Leishmania protozoa transmitted by infected sand flies. Vaccination through leishmanization with live Leishmania major has been used successfully but is no longer practiced because it resulted i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3469c40f3161f1fb3fd912eb07e9cfc5
https://doaj.org/article/a50605a064c049859dfcd1fb76a10dad
https://doaj.org/article/a50605a064c049859dfcd1fb76a10dad