Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Tiago D, Serafim"'
Autor:
Anderson B. Guimaraes-Costa, John P. Shannon, Ingrid Waclawiak, Jullyanna Oliveira, Claudio Meneses, Waldione de Castro, Xi Wen, Joseph Brzostowski, Tiago D. Serafim, John F. Andersen, Heather D. Hickman, Shaden Kamhawi, Jesus G. Valenzuela, Fabiano Oliveira
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Immune mimicry has been shown in chemokine like moieties from bacteria and viruses. Here, the authors characterise a sand fly salivary protein that induces neutrophil chemotaxis and explore its impact in a model of parasitic infection.
Externí odkaz:
https://doaj.org/article/6c6f9032af8240ea805203e2fd59b3d5
Autor:
Pedro Cecílio, James Oristian, Claudio Meneses, Tiago D. Serafim, Jesus G. Valenzuela, Anabela Cordeiro da Silva, Fabiano Oliveira
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Abstract Leishmaniasis is a spectrum of diseases transmitted by sand fly vectors that deposit Leishmania spp. parasites in the host skin during blood feeding. Currently, available treatment options are limited, associated with high toxicity and emerg
Externí odkaz:
https://doaj.org/article/ebd49ccaad9d4970afc0c598e51f5cf8
Autor:
Wen-Wei Zhang, Subir Karmakar, Sreenivas Gannavaram, Ranadhir Dey, Patrick Lypaczewski, Nevien Ismail, Abid Siddiqui, Vahan Simonyan, Fabiano Oliveira, Iliano V. Coutinho-Abreu, Thiago DeSouza-Vieira, Claudio Meneses, James Oristian, Tiago D. Serafim, Abu Musa, Risa Nakamura, Noushin Saljoughian, Greta Volpedo, Monika Satoskar, Sanika Satoskar, Pradeep K. Dagur, J. Philip McCoy, Shaden Kamhawi, Jesus G. Valenzuela, Shinjiro Hamano, Abhay R. Satoskar, Greg Matlashewski, Hira L. Nakhasi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Here, the authors engineer an attenuated knock-out Leishmania (LmCen −/−) vaccine that is safe in immunocompromised mice and induces an immune response and protection similar to leishmanization with wild-type Leishmania. Since LmCen −/− is an
Externí odkaz:
https://doaj.org/article/a50605a064c049859dfcd1fb76a10dad
Autor:
Rajesh Garlapati, Eva Iniguez, Tiago D. Serafim, Prabhas K. Mishra, Basab Rooj, Bikas Sinha, Jesus G. Valenzuela, Sridhar Srikantiah, Caryn Bern, Shaden Kamhawi
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Visceral leishmaniasis (VL) is a potentially deadly parasitic disease. In the Indian sub-continent, VL is caused by Leishmania donovani and transmitted via the bite of an infected Phlebotomus argentipes female sand fly, the only competent vector spec
Externí odkaz:
https://doaj.org/article/8f82388cbc0242918a485f6f6aa50eb5
Autor:
Iliano V Coutinho-Abreu, Tiago D Serafim, Claudio Meneses, Shaden Kamhawi, Fabiano Oliveira, Jesus G Valenzuela
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0008014 (2020)
BACKGROUND:Leishmaniasis is a vector-borne neglected disease. Inside the natural sand fly vector, the promastigote forms of Leishmania undergo a series of extracellular developmental stages to reach the infectious stage, the metacyclic promastigote.
Externí odkaz:
https://doaj.org/article/ae1c4f232ab141ffaa33078100e99709
Autor:
Fernando Fernandez-Cortes, Tiago D. Serafim, Jonathan M. Wilkes, Nathaniel G. Jones, Ryan Ritchie, Richard McCulloch, Jeremy C. Mottram
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Protein kinases (PKs) are a class of druggable targets in Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (sleeping sickness), yet little is known about which PKs are essential for survival in mammals. A recent kinom
Externí odkaz:
https://doaj.org/article/f42ca3b4269e44a1a0bd4fab4c2527c1
Autor:
Eva Iniguez, Samiran Saha, Georgios Petrellis, Claudio Menenses, Samantha Herbert, Yvonne Gonzalez-Rangel, Tobin Rowland, Naomi E Aronson, Clair Rose, Lee Rafuse Haines, Alvaro Acosta-Serrano, Tiago D Serafim, Fabiano Oliveira, Sridhar Srikantiah, Caryn Bern, Jesus G Valenzuela, Shaden Kamhawi
Publikováno v:
The journal of infectious diseases
J Infect Dis
J Infect Dis
Incidence of visceral leishmaniasis (VL) in the Indian subcontinent (ISC) has declined by more than 95% since initiation of the elimination program in 2005. As the ISC transitions to the postelimination surveillance phase, an accurate measurement of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e18ab20f1141f51787dfec7bb35431
https://doi.org/10.1093/infdis/jiac354
https://doi.org/10.1093/infdis/jiac354
Autor:
Jennifer A Stortz, Tiago D Serafim, Sam Alsford, Jonathan Wilkes, Fernando Fernandez-Cortes, Graham Hamilton, Emma Briggs, Leandro Lemgruber, David Horn, Jeremy C Mottram, Richard McCulloch
Publikováno v:
PLoS Pathogens, Vol 13, Iss 7, p e1006477 (2017)
All cells are subject to structural damage that must be addressed for continued growth. A wide range of damage affects the genome, meaning multiple pathways have evolved to repair or bypass the resulting DNA lesions. Though many repair pathways are c
Externí odkaz:
https://doaj.org/article/423fc5b65254441ea7d9fcfdf295c690
Autor:
Patrick H. Kelly, Sarah M. Bahr, Tiago D. Serafim, Nadim J. Ajami, Joseph F. Petrosino, Claudio Meneses, John R. Kirby, Jesus G. Valenzuela, Shaden Kamhawi, Mary E. Wilson
Publikováno v:
mBio, Vol 8, Iss 1 (2017)
ABSTRACT The vector-borne disease leishmaniasis, caused by Leishmania species protozoa, is transmitted to humans by phlebotomine sand flies. Development of Leishmania to infective metacyclic promastigotes in the insect gut, a process termed metacyclo
Externí odkaz:
https://doaj.org/article/d6dd89872da046f8a1e1c0dc1b822334
Autor:
Tiago D. Serafim, Eva Iniguez, Ana Beatriz F. Barletta, Johannes S.P. Doehl, Mara Short, Justin Lack, Pedro Cecilio, Vinod Nair, Maria Disotuar, Timothy Wilson, Iliano V. Coutinho-Abreu, Fabiano Oliveira, Claudio Meneses, Carolina Barillas-Mury, John Andersen, José M.C. Ribeiro, Stephen M. Beverley, Shaden Kamhawi, Jesus G.Valenzuela
Host factors mediating Leishmania genetic exchange are not well defined. Here, we demonstrate that IgM antibodies, but not IgG or IgA, facilitate parasite genetic hybridization in vitro and in vivo. IgM induces the gradual and transient formation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21329f91c586c419bf0b6137b6a2e12f
https://doi.org/10.1101/2022.06.09.495557
https://doi.org/10.1101/2022.06.09.495557
