Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Tia Lewis"'
Autor:
Yong Jiang, Tia Lewis, Patricia M. McCormick, Michael Schaber, Beth Pietrak, Rachel D. Totoritis, Marc A. Holbert, Lawrence M. Szewczuk, Daniel Fornwald, William G. Bonnette, Geoffrey Quinque, Maggie Grimes, Rosalie E. Matico, Ed Dul, Randy K. Bledsoe, Derrick W. Meinhold, Stephanie Chen
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Significant resource is spent by drug discovery project teams to generate numerous, yet unique target constructs for the multiple platforms used to drive drug discovery programs including: functional assays, biophysical studies, structural biology, a
Autor:
Martha Alicia De La Rosa, Kurt Weaver, Lisa M. Shewchuk, Rachel D. Totoritis, John Seal, David Favre, Guofeng Zhang, Makda Mebrahtu, Tia Lewis, Marcel Muelbaier, Richard M. Dunham, Giovanna Bergamini, Jeffrey Guss, Alan R. Rendina, Nino Campobasso, Wieslaw M. Kazmierski, Douglas W. Thomson, Robert Midgett, Katrin Strohmer, Anna Rutkowska-Klute, Rosalie Matico, Thomas Consler, Cunyu Zhang, David Taylor, Sabrina Bédard, Rodrigo F Ortiz-Meoz, Liping Wang
Indoleamine-2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme that catalyzes the rate-limiting step in the kynurenine pathway of tryptophan (TRP) metabolism. As an inflammation-induced immunoregulatory enzyme, pharmacological inhibition of IDO1 ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d6eedaf9b8c5819ab8c1e04bab343a2
https://doi.org/10.1101/324947
https://doi.org/10.1101/324947
Autor:
Wangfang Hou, Thomas D. Meek, Kyung O. Johanson, Xuan Hong, Taylor I Graham, Mui H Cheung, Edward Dul, Sunny T Hung, Allen Oliff, Lawrence M. Szewczuk, Robert B. Kirkpatrick, Thau F. Ho, John J. Kerrigan, Tia Lewis, Martin Brandt, Christopher S. Jones, Sanjay Kumar, Benjamin J. Schwartz, Hong Zhang, Da-Yuan Wang, Patricia M. McCormick, Amber D Harper-Jones
Publikováno v:
ASSAY and Drug Development Technologies. 11:308-325
Small ubiquitin-like modifier (SUMO) belongs to the family of ubiquitin-like proteins (Ubls) that can be reversibly conjugated to target-specific lysines on substrate proteins. Although covalently sumoylated products are readily detectible in gel-bas
Autor:
John J. Kerrigan, Dulcie B. Schmidt, James J. Foley, Abby J. Sukman, Tia Lewis, Patrick McDevitt, Kathleen T. Gallagher, Kyung O. Johanson, Robert S. Ames, James A. Fornwald, Taylor L. Graham, Matthew C. Burns, Quinn Lu, Xiaoyan Tang, Gerald E. Hunsberger
Publikováno v:
Protein Expression and Purification. 65:251-260
We describe here two strategies to produce biologically active chemokines with authentic N-terminal amino acid residues. The first involves producing the target chemokine with an N-terminal 6×His-SUMO tag in Escherichia coli as inclusion bodies. The
Autor:
Juan C. Aon, Lisa A. Wysocki, Femi Oluboyede, Pramatesh S. Patel, Tia Lewis, Richard J. Caimi, Quinn Lu, Jennifer Dally, Alexander H. Taylor, John J. Kerrigan, Michelle D. Kessler
Publikováno v:
Applied and Environmental Microbiology. 74:950-958
Minimization of chemical modifications during the production of proteins for pharmaceutical and medical applications is of fundamental and practical importance. The gluconoylation of heterologously expressed protein which is observed in Escherichia c
Autor:
Robert A. Copeland, Zhihong Lai, Tia Lewis, Kang Yan, Peter J. Tummino, Lata T. Gooljarsingh, John J. Kerrigan, Robert H. Sinnamon, Kyung O. Johanson, Christine Fernandes, Marc R. Arnone, Michael Grooms, Hong Zhang, Alastair J. King, Robert B. Kirkpatrick
Publikováno v:
Proceedings of the National Academy of Sciences. 103:7625-7630
Heat shock protein (Hsp)90 is emerging as an important therapeutic target for the treatment of cancer. Two analogues of the Hsp90 inhibitor geldanamycin are currently in clinical trials. Geldanamycin (GA) and its analogues have been reported to bind