Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Tia Estey"'
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15218 (2010)
As one of the most abundantly expressed proteins in the mammalian corneal epithelium, aldehyde dehydrogenase 3A1 (ALDH3A1) plays critical and multifaceted roles in protecting the cornea from oxidative stress. Recent studies have demonstrated that one
Externí odkaz:
https://doaj.org/article/bf8f2a1a2e474fb895ac060a0fd6d952
Autor:
Shantanu Sule, Suli Liu, Vincent J. Mecozzi, Allan D. Capili, William C. Yang, Kapil Gupta, Jason E. Fernandez, Li Zang, Tia Estey, Pamela Feng, Yana Kravets
Publikováno v:
Journal of pharmaceutical sciences. 106(12)
Characterizing molecular charge variants or isoforms is essential for understanding safety, potency, and bioavailability of antibody therapeutics. However, there is little information on how they influence stability and viscosity-properties governing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2002f468ca1dfbec083b082cff538e70
https://pubmed.ncbi.nlm.nih.gov/28860086
https://pubmed.ncbi.nlm.nih.gov/28860086
Autor:
Theodore W. Randolph, Julianne Cooper, John F. Carpenter, Tia Estey, Christina Vessely, Ian Henderson, LaToya Jones Braun, Rajiv Nayar
Publikováno v:
Journal of Pharmaceutical Sciences. 98:2970-2993
The adsorption of recombinant botulinum neurotoxin (BoNT) protein-derived vaccine antigens to aluminum salt adjuvants has been previously studied for the development of a trivalent vaccine against the neurotoxins (Vessely et al., in press, J Pharm Sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb126892533d493ae0059453f4612285
https://doi.org/10.1002/jps.21498
https://doi.org/10.1002/jps.21498
Publikováno v:
Seminars in Cell & Developmental Biology. 19:100-112
The refracton hypothesis describes the lens and cornea together as a functional unit that provides the proper ocular transparent and refractive properties for the basis of normal vision. Similarities between the lens and corneal crystallins also sugg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56dcf7626b4f7e580f5cbc677a564ba7
https://doi.org/10.1016/j.semcdb.2007.10.004
https://doi.org/10.1016/j.semcdb.2007.10.004
Autor:
Brian J. Day, Jer R. Kuszak, Gregg Duester, J. Bronwyn Bateman, Tia Estey, Lisa M. Hines, Natalie Lassen, Joram Piatigorsky, Vasilis Vasiliou, Jie Huang, David W. Nees
Publikováno v:
Journal of Biological Chemistry. 282:25668-25676
ALDH3A1 (aldehyde dehydrogenase 3A1) is abundant in the mouse cornea but undetectable in the lens, and ALDH1A1 is present at lower (catalytic) levels in the cornea and lens. To test the hypothesis that ALDH3A1 and ALDH1A1 protect the anterior segment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4b578a161065c1c60fd9bfbb9ac8bab
https://doi.org/10.1074/jbc.m702076200
https://doi.org/10.1074/jbc.m702076200
Publikováno v:
Experimental Eye Research. 84:3-12
Aldehyde dehydrogenase 3A1 (ALDH3A1) comprises a surprisingly high proportion (5-50% depending on species) of the water-soluble protein of the mammalian cornea, but is present little if at all in the cornea of other species. Mounting experimental evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838a6fe364e5f74a02a9d74b1f32fc38
https://doi.org/10.1016/j.exer.2006.04.010
https://doi.org/10.1016/j.exer.2006.04.010
Autor:
Shujun Bai, Lantz Steven Andrew, Tia Estey, Maloney Kevin, Pavel Landsman, Karin Lucas, Mark L. Brader, Roy W. Alston
Publikováno v:
Molecular pharmaceutics. 12(4)
Screening for pharmaceutically viable stability from measurements of thermally induced protein unfolding and short-term accelerated stress underpins much molecule design, selection, and formulation in the pharmaceutical biotechnology industry. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a44d01b0ef3897cbcb7f54a489694fa
https://pubmed.ncbi.nlm.nih.gov/25687223
https://pubmed.ncbi.nlm.nih.gov/25687223
Publikováno v:
Drug Metabolism Reviews. 36:279-299
The human genome contains at least 17 genes that are members of the aldehyde dehydrogenase (ALDH) superfamily. These genes encode NAD(P)(+)-dependent enzymes that oxidize a wide range of aldehydes to their corresponding carboxylic acids. Aldehydes ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013cc8b01309c3fa46487f1475a7150b
https://doi.org/10.1081/dmr-120034001
https://doi.org/10.1081/dmr-120034001
Autor:
Tia Estey, Miriam Cantore, Kathryn L. Kavanagh, Valeria V. Orlova, Natalie Lassen, Chad Brocker, Triantafyllos Chavakis, Vasilis Vasiliou, Udo Oppermann, Aglaia Pappa
Publikováno v:
The Journal of biological chemistry. 285(24)
Mammalian ALDH7A1 is homologous to plant ALDH7B1, an enzyme that protects against various forms of stress, such as salinity, dehydration, and osmotic stress. It is known that mutations in the human ALDH7A1 gene cause pyridoxine-dependent and folic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf42fb41a74c500caf927ad1a952e07
http://ora.ox.ac.uk/objects/uuid:7bf285bd-0bc2-4ab2-ba9e-f7b0675adc2d
http://ora.ox.ac.uk/objects/uuid:7bf285bd-0bc2-4ab2-ba9e-f7b0675adc2d
Autor:
Ian Henderson, Theodore W. Randolph, John F. Carpenter, Rajiv Nayar, Tia Estey, Christina Vessely
Publikováno v:
Journal of pharmaceutical sciences. 96(9)
Botulinum neurotoxin (BoNT) is a biological warfare threat. Protein antigens have been developed against the seven major BoNT serotypes for the development of a recombinant protein vaccine. This study is an evaluation of adsorption profiles for three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cba12430e086ada687eff37925e75a6
https://pubmed.ncbi.nlm.nih.gov/17518359
https://pubmed.ncbi.nlm.nih.gov/17518359