Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Ti Zhi-Su"'
Autor:
Jeffrey E. Campbell, Robin Roof, Peter A. Boxer, Johnson Paul D, Ann M. Janssen, Jamie Singer, Jacob Bradley Schwarz, Nicole S. Roush, Leonard T. Meltzer, Chad L. Stoner, Michael William Wilson, Lisa H. Gold, Shelley R. Graham, Susan Hurst, Ti-Zhi Su, Leonard W. Cooke
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2409-2412
The synthesis and SAR of tolylamines with 5-HT6 receptor antagonist activity is presented. The amine, core aromatic, peripheral aromatic, and ether linker moieties of HTS hit 1 were modulated and the effect on potency at 5-HT6 examined. Tolylpiperidi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd3eeb4a5d05425f1061dc9c3cc02895
https://doi.org/10.1016/j.bmcl.2009.03.077
https://doi.org/10.1016/j.bmcl.2009.03.077
Autor:
Steve Bramwell, Emma Stott, Heather L. Melrose, Joanna S Winks, Ross A. Kinloch, Laura Corradini, Dic Williams, Jan Hendrich, Ti-Zhi Su, Peter J. Cox, James Offord, Tony Webb, Steven England, Annette C. Dolphin, Mark J. Field
Publikováno v:
Proceedings of the National Academy of Sciences. 103:17537-17542
Neuropathic pain is a debilitating condition affecting millions of people around the world and is defined as pain that follows a lesion or dysfunction of the nervous system. This type of pain is difficult to treat, but the novel compounds pregabalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674330ad32d2321e8bb4bff2eb886676
https://doi.org/10.1073/pnas.0409066103
https://doi.org/10.1073/pnas.0409066103
Autor:
Thomas G. Heffner, Jack J. Kinsora, Jacob Bradley Schwarz, Ti Zhi-Su, David J. Wustrow, Leonard T. Meltzer, Thomas Richard Belliotti, Thomas Capiris, Andrew John Thorpe, Lawrence D. Wise, Mark L. Weber, Charles Taylor, Mark J. Field, Mark G. Vartanian, I.Victor Ekhato
Publikováno v:
Journal of Medicinal Chemistry. 48:2294-2307
Pregabalin exhibits robust activity in preclinical assays indicative of potential antiepileptic, anxiolytic, and antihyperalgesic clinical efficacy. It binds with high affinity to the alpha(2)-delta subunit of voltage-gated calcium channels and is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05d681e9f725c4f7d0de7f09212832b
https://doi.org/10.1021/jm049762l
https://doi.org/10.1021/jm049762l
Autor:
Ti-Zhi Su, Michael W. Wolff
Publikováno v:
DNA Sequence. 13:15-25
During the last decade, molecular cloning has identified several families of multispecific organic ion transporters mediating the renal and hepatic elimination of organic ions. Clinically, these transporters play important roles in the renal tubular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6ffa09fbdc447c90e402f53802b517
https://doi.org/10.1080/10425170290019856
https://doi.org/10.1080/10425170290019856
Publikováno v:
Biochemical Journal. 342:313-320
Gabapentin [Neurontin, 1-(aminomethyl)cyclohexaneacetic acid] is a novel anticonvulsant drug with a high binding affinity for the Ca 2+ -channel subunit α 2 δ. In this study, the gabapentin-binding properties of wild-type and mutated porcine brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95a8e37f80ac088c911256e6ebcfb562
https://doi.org/10.1042/bj3420313
https://doi.org/10.1042/bj3420313
Publikováno v:
Brain Research. 757:69-78
In the present study, uptake of glutamine by rat cerebellar granule cells, a predominantly glutamatergic nerve cell population, has been investigated. Glutamine is taken up by granule cells via at least three transport systems, A, ASC and L. The L-ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d72d39059824094cba32125e698ca1
https://doi.org/10.1016/s0006-8993(97)00139-x
https://doi.org/10.1016/s0006-8993(97)00139-x
Effects of anticonvulsant drug gabapentin on the enzymes in metabolic pathways of glutamate and GABA
Publikováno v:
Epilepsy Research. 22:1-11
Gabapentin is a novel anticonvulsant drug. The anticonvulsant mechanism of gabapentin is not known. Based on the amino acid structure of gabapentin we explored its possible effects on glutamate and gamma-aminobutyric acid (GABA) metabolism in brain a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eaf4f559dc55241b20ff4dcf91a073b
https://doi.org/10.1016/0920-1211(95)00028-9
https://doi.org/10.1016/0920-1211(95)00028-9
Publikováno v:
Molecular and General Genetics MGG. 230:28-32
The gene products of the ugp operon of Escherichia coli are responsible for the uptake of sn-glycerol-3-phosphate and certain glycerophosphodiesters. The regulation of ugp is mainly phoBR-dependent. Significant expression, however, can be observed ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2216aef70cce541902c7c248af8e2f29
https://doi.org/10.1007/bf00290646
https://doi.org/10.1007/bf00290646
Publikováno v:
Gene. 90:129-133
The ugp promoter (pugp) responsible for expression of the binding-protein-dependent sn-glycerol-3-phosphate transport system in Escherichia coli was cloned into a small multicopy plasmid pTER5, a derivative of pBR322, between the transcription termin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d74d2fe318b5cea225b08f53200850
https://doi.org/10.1016/0378-1119(90)90448-z
https://doi.org/10.1016/0378-1119(90)90448-z
Autor:
Mark G. Vartanian, Po-wai Yuen, Robert M. Schelkun, Jack J. Kinsora, David J. Wustrow, Ti‐Zhi Su
Publikováno v:
ChemInform. 37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a94195c9e70fb76f5f7e84ca40a1d3c
https://doi.org/10.1002/chin.200631173
https://doi.org/10.1002/chin.200631173