Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Thymus gland/immunology"'
Autor:
Santos, Nathália Moreira
Há um amplo espectro de doenças causadas por estreptococos do grupo A (GAS), e são consideradas um problema de saúde pública em vários países, principalmente os em desenvolvimento, com aproximadamente 600 milhões de casos/ano. As infecções
Publikováno v:
Immunogenetics
Immunogenetics, 2019, 71 (3), pp.223-232. ⟨10.1007/s00251-018-1078-y⟩
Immunogenetics, Springer Verlag, 2019, 71 (3), pp.223-232. ⟨10.1007/s00251-018-1078-y⟩
Immunogenetics, 2019, 71 (3), pp.223-232. ⟨10.1007/s00251-018-1078-y⟩
Immunogenetics, Springer Verlag, 2019, 71 (3), pp.223-232. ⟨10.1007/s00251-018-1078-y⟩
International audience; The lifespan of T cells is determined by continuous interactions of their T cell receptors (TCR) with self-peptide-MHC (self-pMHC) complexes presented by different subsets of antigen-presenting cells (APC). In the thymus, deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0acc50af89ab11461537b79f18501d6d
https://www.hal.inserm.fr/inserm-02410117
https://www.hal.inserm.fr/inserm-02410117
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.1262. ⟨10.1038/s41467-018-03619-9⟩
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications, Nature Publishing Group, 2018, 9, ⟨10.1038/s41467-018-03619-9⟩
Lopes, N, Charaix, J, Cédile, O, Sergé, A & Irla, M 2018, ' Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells ', Nature Communications, vol. 9, 1262 . https://doi.org/10.1038/s41467-018-03619-9
Nature Communications, 2018, 9 (1), pp.1262. ⟨10.1038/s41467-018-03619-9⟩
Nature Communications, 2018, 9, ⟨10.1038/s41467-018-03619-9⟩
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.1262. ⟨10.1038/s41467-018-03619-9⟩
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications, Nature Publishing Group, 2018, 9, ⟨10.1038/s41467-018-03619-9⟩
Lopes, N, Charaix, J, Cédile, O, Sergé, A & Irla, M 2018, ' Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells ', Nature Communications, vol. 9, 1262 . https://doi.org/10.1038/s41467-018-03619-9
Nature Communications, 2018, 9 (1), pp.1262. ⟨10.1038/s41467-018-03619-9⟩
Nature Communications, 2018, 9, ⟨10.1038/s41467-018-03619-9⟩
Medullary thymic epithelial cells (mTEC) purge the T cell repertoire of autoreactive thymocytes. Although dendritic cells (DC) reinforce this process by transporting innocuous peripheral self-antigens, the mechanisms that control their thymic entry r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d123e6dea98d352b7b5f815fe02d3417
https://www.hal.inserm.fr/inserm-02438492
https://www.hal.inserm.fr/inserm-02438492
Autor:
Hepworth, Matthew R, Fung, Thomas C, Masur, Samuel H, Kelsen, Judith R, McConnell, Fiona M, Dubrot Armendariz, Juan, Withers, David R, Hugues, Stéphanie, Farrar, Michael A, Reith, Walter, Eberl, Gérard, Baldassano, Robert N, Laufer, Terri M, Elson, Charles O, Sonnenberg, Gregory F
Publikováno v:
Science (New York N.Y.)
Science, Vol. 348, No 6238 (2015) pp. 1031-1035
Science, Vol. 348, No 6238 (2015) pp. 1031-1035
Inflammatory CD4(+) T cell responses to self or commensal bacteria underlie the pathogenesis of autoimmunity and inflammatory bowel disease (IBD), respectively. Although selection of self-specific T cells in the thymus limits responses to mammalian t
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cortical and medullary thymic epithelial cells (cTECs and mTECs, respectively) provide inductive microenvironments for T-cell development and selection. The differentiation pathway of cTEC/mTEC lineages downstream of common bipotent progenitors at di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::024652a8a31bf0689cc4bf753c95ea25
https://hdl.handle.net/10216/114506
https://hdl.handle.net/10216/114506
Publikováno v:
European Journal of Immunology
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Thymic epithelial cells (TECs) provide key instructive signals for T-cell differentiation. Thymic cortical (cTECs) and medullary (mTECs) epithelial cells constitute two functionally distinct microenvironments for T-cell development, which derive from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6d0796cfe6eea96593236e2fd6187edc
https://hdl.handle.net/10216/114507
https://hdl.handle.net/10216/114507
Publikováno v:
European Journal of Immunology, vol. 44, no. 9, pp. 2567-2570
European Journal of Immunology
European Journal of Immunology
The Melan-A/MART-1(26-35) antigenic peptide is one of the best studied human tumor-associated antigens. It is expressed in healthy melanocytes and malignant melanoma and is recognized by CD8(+) T cells in the context of the MHC class I molecule HLA-A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40d8a2f54289d77a382b6c1e75af2d1
https://serval.unil.ch/resource/serval:BIB_2573E29B94C8.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_2573E29B94C8.P001/REF.pdf
Autor:
Nathália Moreira Santos
Publikováno v:
Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.
Há um amplo espectro de doenças causadas por estreptococos do grupo A (GAS), e são consideradas um problema de saúde pública em vários países, principalmente os em desenvolvimento, com aproximadamente 600 milhões de casos/ano. As infecções
Publikováno v:
The Journal of experimental medicine
Journal of Experimental Medicine
Journal of Experimental Medicine, vol. 209, no. 10, pp. 1769-1779
The Journal of Experimental Medicine
Journal of Experimental Medicine, Vol. 209, No 10 (2012) pp. 1769-79
Journal of Experimental Medicine
Journal of Experimental Medicine, vol. 209, no. 10, pp. 1769-1779
The Journal of Experimental Medicine
Journal of Experimental Medicine, Vol. 209, No 10 (2012) pp. 1769-79
Autoimmunity occurs because central and peripheral tolerance mechanisms fail to tolerize T cells with weak self-reactivity to tissue-restricted antigen.
Central and peripheral tolerance prevent autoimmunity by deleting the most aggressive CD8+ T
Central and peripheral tolerance prevent autoimmunity by deleting the most aggressive CD8+ T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7db3bc3cecf0a23fb2580ed43a798b
http://resolver.sub.uni-goettingen.de/purl?gs-1/10626
http://resolver.sub.uni-goettingen.de/purl?gs-1/10626
Autor:
Alfred Singer, Georgi S Angelov, Lionel Feigenbaum, Susanna Jeurling, Xuguang Tai, Leonid A. Pobezinsky, Jung-Hyun Park, François Van Laethem
Publikováno v:
Nature immunology
Nature Immunology, vol. 13, no. 6, pp. 569-578
Nature Immunology, vol. 13, no. 6, pp. 569-578
Clonal deletion of autoreactive thymocytes is important for self-tolerance, but the intrathymic signals that induce clonal deletion have not been clearly identified. We now report that clonal deletion during negative selection required CD28-mediated