Výsledky vyhledávání - "Thymus Gland/cytology"

Akademický článek

Cbx4 regulates the proliferation of thymic epithelial cells and thymus function

Autor: Liu, B., Liu, Y. F., Du, Y. R., Mardaryev, A. N., Yang, W., Chen, H., Xu, Z. M., Xu, C. Q., Zhang, X. R., Botchkarev, V. A., Zhang, Y., Xu, G. L.

Thymic epithelial cells (TECs) are the main component of the thymic stroma, which supports T-cell proliferation and repertoire selection. Here, we demonstrate that Cbx4, a Polycomb protein that is highly expressed in the thymic epithelium, has an ess

Externí odkaz: http://hdl.handle.net/10454/6068

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Thymus-Derived Mesenchymal Stem Cells for Tissue Engineering Clinical-Grade Cardiovascular Grafts

Autor: Megan M. Swim, Mohamed T. Ghorbel, Dominga Iacobazzi, Ambra Albertario, Massimo Caputo

Publikováno v: Iacobazzi, D, Swim, M M, Albertario, A, Caputo, M & Ghorbel, M T 2018, ' Thymus-Derived Mesenchymal Stem Cells for Tissue Engineering Clinical-Grade Cardiovascular Grafts ', Tissue Engineering, Part A, vol. 24, no. 9-10, pp. 794-808 . https://doi.org/10.1089/ten.tea.2017.0290, https://doi.org/10.1089/ten.TEA.2017.0290

Mesenchymal stem cells (MSCs) are attractive tools for regenerative medicine because of their multidifferentiation potential and immunomodulation capacity. In congenital heart defect surgical correction, replacement grafts lacking growth potential ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74943354d5a2cbf23889b0dd615b57e
https://research-information.bris.ac.uk/en/publications/6bd5b533-cfd7-4230-944b-15b5a1b38536

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Thymic crosstalk restrains the pool of cortical thymic epithelial cells with progenitor properties

Autor: Catarina Meireles, Nuno L. Alves, Rute D. Pinto, Pedro M. Rodrigues, Catarina Leitão, Ana R. Ribeiro

Publikováno v: European Journal of Immunology
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Cortical (cTEC) and medullary (mTEC) thymic epithelial cells establish key microenvironments for T-cell differentiation and arise from thymic epithelial cell progenitors (TEP). However, the nature of TEPs and the mechanism controlling their stemness

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d1a737e2bf003ee7cde51a60609ee4

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Notch 1–Deficient Common Lymphoid Precursors Adopt a B Cell Fate in the Thymus

Autor: Freddy Radtke, H. Robson MacDonald, Anne Wilson

Publikováno v: The Journal of Experimental Medicine
The Journal of experimental medicine, vol. 194, no. 7, pp. 1003-1012

We have recently reported that Notch 1, a member of the Notch multigene family, is essential for the development of murine T cells. Using a mouse model in which Notch 1 is inactivated in bone marrow (BM) precursors we have shown that B cells instead

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae4529120d8ae91646484818c06c8741
http://europepmc.org/articles/PMC2193487

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Notch1 Deficiency Dissociates the Intrathymic Development of Dendritic Cells and T Cells

Autor: Anne Wilson, Michel Aguet, R K Lees, H. Robson MacDonald, Freddy Radtke, Isabel Ferrero

Publikováno v: Journal of Experimental Medicine, vol. 191, no. 7, pp. 1085-1094
The Journal of Experimental Medicine

Thymic dendritic cells (DCs) form a discrete subset of bone marrow (BM)-derived cells, the function of which is to mediate negative selection of autoreactive thymocytes. The developmental origin of thymic DCs remains controversial. Although cell tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c90f10c7f4b584d6ca38a67cf065286
https://doi.org/10.1084/jem.191.7.1085

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The RAG2 C terminus suppresses genomic instability and lymphomagenesis

Autor: Yi-Fan Chou, Sandy Chang, Jane A. Skok, Marc Coussens, Ludovic Deriano, Alexander V. Alekseyenko, Asha S. Multani, David Roth, Julie Chaumeil

Publikováno v: Nature
Nature, Nature Publishing Group, 2011, 471 (7336), pp.119-23. <10.1038/nature09755>
Nature, Nature Publishing Group, 2011, 471 (7336), pp.119-23. ⟨10.1038/nature09755⟩

International audience; Misrepair of DNA double-strand breaks produced by the V(D)J recombinase (the RAG1/RAG2 proteins) at immunoglobulin (Ig) and T cell receptor (Tcr) loci has been implicated in pathogenesis of lymphoid malignancies in humans and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68201a1584bb5654fa874ba945a64c81
https://doi.org/10.1038/nature09755

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Regulation of B Versus T Lymphoid Lineage Fate Decision by the Proto-Oncogene LRF

Autor: Giorgio Cattoretti, Takahiro Maeda, Taha Merghoub, Koichi Akashi, Pier Paolo Pandolfi, Hirokazu Shigematsu, Marcel R.M. van den Brink, Arthur Zelent, Julie Teruya-Feldstein, Manami Maeda, Lin Dong, Robin M. Hobbs, Johannes L. Zakrzewski

Publikováno v: Science. 316:860-866

Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8048846c9441853cbc78f0928d4e08
https://doi.org/10.1126/science.1140881

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Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions

Autor: Yves Lepelletier, Mireille Dardenne, Ana Cristina Martins de Almeida Nogueira, Olivier Hermine, Wilson Savino, Salete Smaniotto, Déa Maria Serra Villa-Verde, Réda Hadj-Slimane

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2007, 104, pp.5545-5550
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2007, 104, pp.5545-5550. ⟨10.1073/pnas.0700705104⟩

It is largely established that molecules first discovered in the nervous system are also found in the immune system. Neuropilin-1 (NP-1) was initially identified to mediate semaphorin-induced chemorepulsion during brain development and is also involv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632e6d9457a82a7401f9dfc62b512b01
https://doi.org/10.1073/pnas.0700705104

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The Wiskott-Aldrich syndrome protein is required for the function of CD4+CD25+Foxp3+ regulatory T cells

Autor: Vinicius Cotta-de-Almeida, Fuminao Takeshima, Scott B. Snapper, Atul K. Bhan, Pierre Michetti, Michel H. Maillard, Deanna D. Nguyen, Cathryn R. Nagler

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine, vol. 204, no. 2, pp. 381-91

The Wiskott-Aldrich syndrome, a primary human immunodeficiency, results from defective expression of the hematopoietic-specific cytoskeletal regulator Wiskott-Aldrich syndrome protein (WASP). Because CD4+CD25+Foxp3+ naturally occurring regulatory T (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0333280b48587c61bd2a87aebe45f681
http://europepmc.org/articles/PMC2118715

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Mitochondria-independent induction of Fas-mediated apoptosis by MSSP

Autor: Ken-ichi Matsumoto, Jun Nomura, Hiroyoshi Ariga, Sanae M.M. Iguchi-Ariga

Publikováno v: Scopus-Elsevier

Fas-mediated apoptosis has been proposed to play an important role in homeostasis. Fas triggers apoptosis after stimulation by its ligand FasL or the Fas ligand agonist anti-Fas antibody through a mitochondria-dependent or -independent pathway, and M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4b634672592556e06737515c41834e
http://hdl.handle.net/2115/53731

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