Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Thymidylate synthase activity"'
Autor:
Christina Davidian, Zhiyuan Mao, Karen Lam, Madeline Yung, Marisa London, Jeffrey H Miller, Lisa Yun Song, Marisa Goff
Publikováno v:
Antimicrobial agents and chemotherapy, vol 60, iss 10
We examined the mutagenic specificity of the widely used antibiotic ciprofloxacin (CPR), which displays weak to moderate mutagenic activity in several bacteria and generates short in-frame deletions in rpoB in Staphylococcus aureus . To determine the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e66ad2e192b3a1c0eb75610b57f30f5
https://doi.org/10.1128/aac.01415-16
https://doi.org/10.1128/aac.01415-16
Autor:
Koji Ando, Eiji Oki, Sugiko Watanabe, Eriko Tokunaga, Kazuaki Matsuoka, Shinichi Kiyonari, Hiroyuki Kitao, Mamoru Kiniwa, Hiroshi Saeki, Hiroshi Tsukihara, Makoto Iimori, Shinichiro Niimi, Yoshihiko Maehara
Publikováno v:
Molecular Cancer Therapeutics. 14:1004-1013
Trifluridine (FTD) is a key component of the novel oral antitumor drug TAS-102, which consists of FTD and a thymidine phosphorylase inhibitor. Like 5-fluoro-2′-deoxyuridine (FdUrd), a deoxynucleoside form of 5-fluorouracil metabolite, FTD is sequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b3cc0765d2b29c86eb1672120dfeca
https://doi.org/10.1158/1535-7163.mct-14-0236
https://doi.org/10.1158/1535-7163.mct-14-0236
Autor:
Piotr Maj, Piotr Wilk, Małgorzata Prokopowicz, Justyna Sobich, Zbigniew Zieliński, Tomasz Frączyk, Wojciech Rode
Publikováno v:
Archives of Biochemistry and Biophysics. 674:108106
In view of previous crystallographic studies, N4-hydroxy-dCMP, a slow-binding thymidylate synthase inhibitor apparently caused “uncoupling” of the two thymidylate synthase-catalyzed reactions, including the N5,10-methylenetetrahydrofolate one-car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b2542ef815eca002c9d7e9464e090f5
https://doi.org/10.1016/j.abb.2019.108106
https://doi.org/10.1016/j.abb.2019.108106
Publikováno v:
Molecular Microbiology. 77:1502-1511
Thymidylate, an essential building block of DNA, is synthesized either from deoxyuridylate by thymidylate synthase (TS) or thymidine (dT) by thymidine kinase (TK). Thymidylate kinase (TMPK) phosphorylates dTMP to dTTP. Thymidine phosphorylase (TP) ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70fe5e3c73cfde67139e96a17f9ddfb4
https://doi.org/10.1111/j.1365-2958.2010.07298.x
https://doi.org/10.1111/j.1365-2958.2010.07298.x
Autor:
C E de Bock, Lisa F. Lincz, Jennette A. Sakoff, Stephen P. Ackland, N Scott, F. E. Scorgie, M B Garg
Publikováno v:
The Pharmacogenomics Journal. 11:307-314
Two known polymorphisms in the 5' enhancer region (ER) of the thymidylate synthase (TS) gene, a variable number of tandem repeats of a 28 bp sequence (2R/3R) and a further G>C single nucleotide substitution within the repeats, result in genotypes wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b580727085ebe7372b7e6bbb95b06420
https://doi.org/10.1038/tpj.2010.43
https://doi.org/10.1038/tpj.2010.43
Autor:
Nozomu Tanaka, Kenichi Matsuo, Hiroyuki Ueno, Akiko Osada, Hiroyuki Okabe, Kei Oguchi, Tatsushi Yokogawa, Hiromi Kazuno, Keiji Ishida, Kazuki Sakamoto, Yukari Yamada
Publikováno v:
International Journal of Oncology
Trifluridine (FTD) and 2′-deoxy-5-fluorouridine (FdUrd), a derivative of 5-fluorouracil (5-FU), are antitumor agents that inhibit thymidylate synthase activity and their nucleotides are incorporated into DNA. However, it is evident that several dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7631922ccc5cd056f3d2abc0c3947662
https://pubmed.ncbi.nlm.nih.gov/25901475
https://pubmed.ncbi.nlm.nih.gov/25901475
Autor:
John A. Gerlt, Richard W. Pierce, Steven C. Almo, Alexander A. Fedorov, Wen Shan Yew, John F. Rakus, Elena V. Fedorov
Publikováno v:
Biochemistry. 45:14582-14597
Many members of the mechanistically diverse enolase superfamily have unknown functions. In this report we use both genome (operon) context and screening of a library of acid sugars to assign the L-fuconate dehydratase (FucD) function to a member of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62aba8f8f5a8c49ea4eb365136963dcd
https://doi.org/10.1021/bi061687o
https://doi.org/10.1021/bi061687o
Publikováno v:
Molecular Cancer Therapeutics. 5:2023-2033
Dysregulated cellular proliferation is a characteristic property of cancer. We show that, despite this fact, cancers maintain high amplitude, circadian rhythms in their growth, DNA synthesis, and mitosis. These patterns are accompanied by the daily t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2dc288336ea24fe4c254ed42287757e
https://doi.org/10.1158/1535-7163.mct-06-0177
https://doi.org/10.1158/1535-7163.mct-06-0177
Publikováno v:
Anti-Cancer Drugs. 17:807-813
The current reference treatment of hormone-refractory prostate cancer consists mainly of chemotherapy with docetaxel. To improve the management of advanced prostate cancer, one should examine the benefits of adding other agents to docetaxel. We exami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e183ec93afdcdf0b3f12a360911d333a
https://doi.org/10.1097/01.cad.0000224444.23953.90
https://doi.org/10.1097/01.cad.0000224444.23953.90
Autor:
Merrill J. Egorin, Clive Brown-Proctor, Paul E. Kinahan, Chester A. Mathis, Jerry M. Collins, Deborah R. Hamburger, Julie L. Eiseman, Erin Joseph, Raymond W. Klecker, Lawrence W. Anderson, Su-Shu Pan
Publikováno v:
Clinical Cancer Research. 10:6669-6676
Purpose: In colorectal, breast, and head and neck cancers, response to 5-fluorouracil is associated with low expression of thymidylate synthase. In contrast, tumors with high expression of thymidylate synthase may be more sensitive to prodrugs such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf03e2f44fc0a39ba607450c0904f2f4
https://doi.org/10.1158/1078-0432.ccr-03-0686
https://doi.org/10.1158/1078-0432.ccr-03-0686