Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Thymidine phosphorylase activity"'
Autor:
Fazal Rahim, Fahad Khan, Hayat Ullah, Imad Uddin, Anjum Liaqat, Qudrat Ullah Khan, Zia Ur Rehman, Muhammad Taha
Publikováno v:
Chemical Papers. 76:213-224
A series of seventeen analogs (1─17) were synthesized and characterized through different spectroscopic techniques such as 1H, 13CNMR, HR-EI-MS and were evaluated for in vitro thymidine phosphorylase inhibition. All compounds showed excellent to go
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d45fa42c8334eb6779a0dab383d93d8a
https://doi.org/10.1007/s11696-021-01842-1
https://doi.org/10.1007/s11696-021-01842-1
Publikováno v:
Journal of Stress Physiology & Biochemistry, Vol 8, Iss 3, Pp 113-119 (2012)
Aim: To understand the association between markers of oxidative stress and angiogenesis in relation to disease progression, clinical stage and cytological grade in patho-physiology of prostate carcinoma.Patients and Methods: Case control study compri
Externí odkaz:
https://doaj.org/article/3649cb46153e478dae849579805f753c
A comparative study of enzyme activity features of thymidilate "salvage pathway" synthesis and adenosine catabolism in blood serum and cancer tissues from solid adjacent tumors of different localizations was carried out. Aim: To evaluate both the dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316b5cb2cd68b870c21989b8f797113e
https://doi.org/10.9734/bpi/hmmr/v10/7417d
https://doi.org/10.9734/bpi/hmmr/v10/7417d
Autor:
Fazal Rahim, Naveed Iqbal, Abdulelah Altolayyan, Munther Alomari, Nizam Uddin, Bushra Adalat, Mohamad Ibrahim, Khalid Mohammed Khan, Noor B. Almandil, Fasial Nawaz, Bandar Alghanem, Ebaa Ahmed Jassim Aldhamin, El Hassane Anouar, Muhammad Taha
Publikováno v:
Bioorganic chemistry. 98
In this study, a series of indole based acetohydrazide derivatives (1–22) were synthesized and characterized by 13C NMR, 1H NMR and HREI-MS. The resulted derivatives were tested for thymidine phosphorylase inhibitory potential. These derivatives in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09cce13c5c7944a54c263537ffbd384
https://pubmed.ncbi.nlm.nih.gov/32200327
https://pubmed.ncbi.nlm.nih.gov/32200327
Autor:
Fazal Rahim, Mohsan Nawaz, Imad Uddin, Khalid Mohammed Khan, Muhammad Taha, Rai Khalid Farooq, Hayat Ullah, Zainul Wahab, Syed Adnan Ali Shah, Abdul Wadood
Publikováno v:
Bioorganic Chemistry. 78:58-67
We have synthesized oxadiazole derivatives (1–16), characterized by 1H NMR, 13C NMR and HREI-MS and screened for thymidine phosphorylase inhibitory potential. All derivatives display varied degree of thymidine phosphorylase inhibition in the range
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4c1cb7361b6a0e149e1deab3ae9fde
https://doi.org/10.1016/j.bioorg.2018.02.020
https://doi.org/10.1016/j.bioorg.2018.02.020
Autor:
William E. Berquist, Kimberly A. Kripps, David Cristin, Michio Hirano, Rowland W Pettit, Michael L. Kueht, Natalia Gomez-Ospina, Sarah H. Elsea, Austin Larson, Brian J. Shayota, Lisa Emrick, Fernando Scaglia, Carlos O. Esquivel, Youmna A. Sherif, Waldo Concepcion, Warapan Nakayuenyongsuk, Elizabeth A. Pomfret, Samuel Gilliland, Ryan Himes, Whitney E. Jackson, Gregory M. Enns, Jacinda B. Sampson, Johan L.K. Van Hove
Publikováno v:
Mol Genet Metab
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a fatal disorder characterized by progressive gastrointestinal dysmotility, peripheral neuropathy, leukoencephalopathy, skeletal myopathy, ophthalmoparesis, and ptosis. MNGIE stems from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6180a2fb3ef107f5b62247ecaa977bb
https://pubmed.ncbi.nlm.nih.gov/32173240
https://pubmed.ncbi.nlm.nih.gov/32173240
Publikováno v:
Abstracts Accepted for Publication.
Background: Angiogenesis, which is the growth of new capillaries from pre-existing blood vessels, is an essential pathological feature of rheumatoid arthritis (RA). Gliostatin (GLS) is known to have angiogenic activity and thymidine phosphorylase act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9fc0d697a789619fd1378ddfe9a9a0e
https://doi.org/10.1136/annrheumdis-2019-eular.4074
https://doi.org/10.1136/annrheumdis-2019-eular.4074
Autor:
Anna Tzani, Dick Pluim, Bart A. W. Jacobs, Jan H.M. Schellens, Pia van der Laan, Jos H. Beijnen
Publikováno v:
Nucleosides and Nucleotides, 37(8), 436. Taylor and Francis Ltd.
The enzyme thymidine phosphorylase (TP) is important for activation of capecitabine and 5-fluorouracil. Assessment of TP phenotype might be suitable for identification of patients at risk of fluoropyrimidine-induced toxicity. In this paper, we descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49c22f933c9c74d1a85bd32fdcf5a6b
https://pubmed.ncbi.nlm.nih.gov/30285552
https://pubmed.ncbi.nlm.nih.gov/30285552
Publikováno v:
BMC Gastroenterology
BMC Gastroenterology, Vol 19, Iss 1, Pp 1-5 (2019)
BMC Gastroenterology, Vol 19, Iss 1, Pp 1-5 (2019)
Background Mitochondrial neurogastrointestinal encephalopathy (MNGIE), due to mutations in TYMP, often presents with gastrointestinal symptoms. Two sisters, initially managed for Crohn’s disease based upon clinical, imaging and pathological finding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89638cc8c8599735d00b3f3902add0a0
https://pubmed.ncbi.nlm.nih.gov/30646848
https://pubmed.ncbi.nlm.nih.gov/30646848
Autor:
Eje Ingvar Kagevi, Musthafa Chalikandy Peedikayil, Moeenaldeen Dia Alsayed, Hazzaa Alzahrani, Ehab H Abu-Farhaneh
Publikováno v:
Hematology/Oncology and Stem Cell Therapy, Vol 8, Iss 2, Pp 85-90 (2015)
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive disorder. The mutation in the ECGF1 gene causes severe deficiency of thymidine phosphorylase (TP), which in turn increases thymidine and deoxyuridine in the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb06b91abeccef106ea7d9b732fb59b8
https://doi.org/10.1016/j.hemonc.2014.12.001
https://doi.org/10.1016/j.hemonc.2014.12.001