Zobrazeno 1 - 10
of 1 291
pro vyhledávání: '"Thymic involution"'
Autor:
Craig P. Collins, Lam T. Khuat, Gail D. Sckisel, Logan V. Vick, Christine M. Minnar, Cordelia Dunai, Catherine T. Le, Brendan D. Curti, Marka Crittenden, Alexander Merleev, Michael Sheng, Nelson J. Chao, Emanual Maverakis, Spencer R. Rosario, Arta M. Monjazeb, Bruce R. Blazar, Dan L. Longo, Robert J. Canter, William J. Murphy
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The thymus is the central organ involved with T-cell development and the production of naïve T cells. During normal aging, the thymus undergoes marked involution, reducing naïve T-cell output and resulting in a predominance of long-lived memory T c
Externí odkaz:
https://doaj.org/article/1e288536df9248b1a327800dd3a6007e
Publikováno v:
陆军军医大学学报, Vol 46, Iss 6, Pp 567-577 (2024)
Objective To investigate the role and underlying mechanism of insulin like growth factor binding protein 5 (IGFBP5), a gene up-regulated with age in thymic epithelial cells, in the pathogenesis of thymic involution. Methods Different gene expression
Externí odkaz:
https://doaj.org/article/9402a42845194ccdb8c4e8298b0fb5a2
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe thymus plays a central role in shaping human immune function. A mechanistic, quantitative description of immune cell dynamics and thymic output under homeostatic conditions and various patho-physiological scenarios are of particular int
Externí odkaz:
https://doaj.org/article/21c1dcc9373a424bb01e946ea35bb480
Autor:
Li Bingxin, Ye Yaqiong, Hong Longsheng, Li Wanyan, Wu Qingru, Liu Wenjun, Ma Yongjiang, Xu Danning, Li Yugu
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 55, Pp 548-560 (2023)
Age-related thymic involution is one of the significant reasons for induced immunity decline. Recent evidence has indicated that lncRNAs are widely involved in regulating organ development. However, the lncRNA expression profiles in mouse thymic invo
Externí odkaz:
https://doaj.org/article/bd7021ab7f7447c9a584ab2a7d9c6c61
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Thymic epithelial cells (TECs) are essential for T cell development in the thymus, yet the mechanisms governing their differentiation are not well understood. Lin28, known for its roles in embryonic development, stem cell pluripotency, and regulating
Externí odkaz:
https://doaj.org/article/3ce377840acc4a1dba16a1cc862449b2
Akademický článek
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Akademický článek
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Autor:
Lucyle Depoërs, Maude Dumont-Lagacé, Vincent Quoc-Huy Trinh, Chloé Houques, Caroline Côté, Jean-David Larouche, Sylvie Brochu, Claude Perreault
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Pregnancy causes abrupt thymic atrophy. This atrophy is characterized by a severe decrease in the number of all thymocyte subsets and qualitative (but not quantitative) changes in thymic epithelial cells (TECs). Pregnancy-related thymic involution is
Externí odkaz:
https://doaj.org/article/4eea7ff4a6ce4f34b4f96a6bf9bb021b
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The brain has long been considered an immune-privileged organ due to the presence of the blood-brain barrier (BBB). However, recent discoveries have revealed the underestimated role of T cells in the brain through the meningeal lymphatic system. Age
Externí odkaz:
https://doaj.org/article/98bb998c0e3b4ae5a4ce9523ec7532fe
Autor:
Logan V. Vick, Craig P. Collins, Lam T. Khuat, Ziming Wang, Cordelia Dunai, Ethan G. Aguilar, Kevin Stoffel, Sai Yendamuri, Randall Smith, Sarbajit Mukherjee, Joseph Barbi, Robert J. Canter, Arta M. Monjazeb, William J. Murphy
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionThe incidence of obesity, a condition characterized by systemic chronic inflammation, has reached pandemic proportions and is a poor prognostic factor in many pathologic states. However, its role on immune parameters has been diverse and
Externí odkaz:
https://doaj.org/article/c987ad8e2be041e09bc0520fda51dba8