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pro vyhledávání: '"Thymic Medullary Epithelial Cell"'
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Publikováno v:
Histochemistry and Cell Biology. 114:9-14
Calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, plays an important role in various physiological functions including T cell activation. This enzyme is a target molecule for the immunosuppressants, cyclosporin A and FK506. In the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ea2273cd9d1050695cf44e18b6e384
https://doi.org/10.1007/s004180000168
https://doi.org/10.1007/s004180000168
Autor:
Qing Ge, Weifeng Chen
Publikováno v:
Chinese Science Bulletin. 44:1571-1576
A murine CD4+ thymocyte subset with phenotype of TCRαβ+ 3G11− 6C10− CD4+ CD8− CD69+/- HSAmed/lo contains the cells in relatively functional matured status. The functional property of the cells in this subset is characterized by the unique pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50533a0c767b87f4f72bd105625604d4
https://doi.org/10.1007/bf02886094
https://doi.org/10.1007/bf02886094
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine
Journal of Experimental Medicine
Thymocytes depend on the interaction with thymic epithelial cells for the generation of a diverse, nonautoreactive T cell repertoire. In turn, thymic epithelial cells acquire their three-dimensional cellular organization via instructive signals from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3cad27284486819ba542be28c18736
https://pubmed.ncbi.nlm.nih.gov/12953095
https://pubmed.ncbi.nlm.nih.gov/12953095
Publikováno v:
Immunology letters. 72(2)
Using an in vitro co-culture assay we found that a rat medullary thymic epithelial cell (TEC) line (TE-R2.5) induces apoptosis of the BWRT8 thymocyte hybridoma (TH) (CD4(hi)CD8(low) alphabetaTCR(hi)). TH apoptosis induced by this TEC line was predomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae58f16e3aebb454f2f4097991ad6d66
https://pubmed.ncbi.nlm.nih.gov/10841942
https://pubmed.ncbi.nlm.nih.gov/10841942
Publikováno v:
Science in China. Series C, Life sciences. 41(2)
Thymic medullary type epithelial cell line (MTEC1), which expressed H-2D(d) and Ia(d), was derived from BALB/c mouse. MTEC1 cells were introduced by intrathymic injection into irradiated H-2(b) mice reconstituted with H-2(bxd) F1bone marrow cells. Tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab9b513f7de931c8b730472ce8af70ec
https://pubmed.ncbi.nlm.nih.gov/18726207
https://pubmed.ncbi.nlm.nih.gov/18726207
Publikováno v:
Gene. 143(2)
Medullary epithelial cells of the thymus can be activated by contact with thymocytes. We identified a number of protein tyrosine kinases (PTKs) that could be responsible for the tyrosine phosphorylation observed in a murine thymic medullary epithelia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ddce294a7b62e8e9a3649b92b7a3165
https://pubmed.ncbi.nlm.nih.gov/8206383
https://pubmed.ncbi.nlm.nih.gov/8206383
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781441973108
The orderly interactions between thymocytes at discrete stages of their differentiation and particular stromal elements generate a predictable phenotypic profile of thymocyte subsets (Scollay and Shortman, 1986). Interference with such interactions b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e66a269be6c77dddc0069bc6d0dd1b9
https://doi.org/10.1007/978-1-4615-2492-2_15
https://doi.org/10.1007/978-1-4615-2492-2_15
Publikováno v:
Immunology letters. 37(1)
We have previously described a type of lymphoepithelial interaction involving CD4 + CD8 + thymocytes and a medullary epithelial cell line (E-5). This interaction is mediated by the recently described gp23/45 epithelial adhesion molecule and an as yet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb6bf3ea1481a49f060d8212841080c
https://pubmed.ncbi.nlm.nih.gov/8225406
https://pubmed.ncbi.nlm.nih.gov/8225406
Autor:
Edouard F. Potworowski, Patrice Hugo
Publikováno v:
Cellular immunology. 126(1)
The role of lymphostromal complexes in T-cell differentiation is far from elucidated, mainly because a clear association of a particular stromal cell type with a distinct thymocyte subset has never been identified. Using an in vitro system, detecting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29f25046cc4f9489d6d1954dca737c2
https://pubmed.ncbi.nlm.nih.gov/2105850
https://pubmed.ncbi.nlm.nih.gov/2105850