Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assembly.

Autor: Li Y; Institute of Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia., Pacoste LC; Department of Materials and Environmental Chemistry, Stockholm University, Frescativägen 8, 114 18 Stockholm, Sweden., Gu W; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia., Thygesen SJ; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia., Stacey KJ; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia., Ve T; Institute for Glycomics, Griffith University, Southport, Queensland 4215, Australia., Kobe B; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia., Xu H; Department of Materials and Environmental Chemistry, Stockholm University, Frescativägen 8, 114 18 Stockholm, Sweden., Nanson JD; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia.

Publikováno v: Acta crystallographica. Section D, Structural biology [Acta Crystallogr D Struct Biol] 2024 Sep 01; Vol. 80 (Pt 9), pp. 699-712. Date of Electronic Publication: 2024 Sep 04.

Fluorochrome-labeled inhibitors of caspase-1 require membrane permeabilization to efficiently access caspase-1 in macrophages.

Autor: Thygesen SJ; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Australia., Burgener SS; Institute for Molecular Bioscience (IMB) and IMB Centre for Inflammation and Disease Research, The University of Queensland, St Lucia, Australia., Mudai P; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Australia., Monteleone M; Institute for Molecular Bioscience (IMB) and IMB Centre for Inflammation and Disease Research, The University of Queensland, St Lucia, Australia., Boucher D; York Biomedical Research Institute, Department of Biology, University of York, York, United Kingdom., Sagulenko V; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Australia., Schroder K; Institute for Molecular Bioscience (IMB) and IMB Centre for Inflammation and Disease Research, The University of Queensland, St Lucia, Australia.; Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Australia., Stacey KJ; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Australia.; Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Australia.

Publikováno v: European journal of immunology [Eur J Immunol] 2024 May; Vol. 54 (5), pp. e2350515. Date of Electronic Publication: 2024 Feb 15.

MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.

Autor: Clabbers MTB; Department of Materials and Environmental Chemistry, Stockholm University, Stockholm, Sweden.; Department of Biological Chemistry, University of California Los Angeles, Los Angeles, California, USA., Holmes S; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia., Muusse TW; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia., Vajjhala PR; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia., Thygesen SJ; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia., Malde AK; Institute for Glycomics, Griffith University, Southport, Queensland, Australia., Hunter DJB; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.; EMBL Australia Node in Single Molecule Science, University of New South Wales, Kensington, New South Wales, Australia.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia., Croll TI; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK., Flueckiger L; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia., Nanson JD; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia., Rahaman MH; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia., Aquila A; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Hunter MS; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Liang M; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Yoon CH; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Zhao J; Department of Materials and Environmental Chemistry, Stockholm University, Stockholm, Sweden., Zatsepin NA; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia., Abbey B; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia., Sierecki E; EMBL Australia Node in Single Molecule Science, University of New South Wales, Kensington, New South Wales, Australia., Gambin Y; EMBL Australia Node in Single Molecule Science, University of New South Wales, Kensington, New South Wales, Australia., Stacey KJ; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland, Australia., Darmanin C; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia. c.darmanin@latrobe.edu.au., Kobe B; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia. b.kobe@uq.edu.au.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia. b.kobe@uq.edu.au.; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland, Australia. b.kobe@uq.edu.au., Xu H; Department of Materials and Environmental Chemistry, Stockholm University, Stockholm, Sweden. hongyi.xu@mmk.su.se., Ve T; Institute for Glycomics, Griffith University, Southport, Queensland, Australia. t.ve@griffith.edu.au.

Publikováno v: Nature communications [Nat Commun] 2021 May 10; Vol. 12 (1), pp. 2578. Date of Electronic Publication: 2021 May 10.

IRF1 and IRF2 regulate the non-canonical inflammasome.

Autor: Thygesen SJ; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Qld, Australia., Stacey KJ; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Qld, Australia.

Publikováno v: EMBO reports [EMBO Rep] 2019 Sep; Vol. 20 (9), pp. e48891. Date of Electronic Publication: 2019 Aug 05.

Assessment of Inflammasome Formation by Flow Cytometry.

Autor: Sester DP; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia., Zamoshnikova A; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia., Thygesen SJ; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia., Vajjhala PR; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia., Cridland SO; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia., Schroder K; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia., Stacey KJ; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.

Publikováno v: Current protocols in immunology [Curr Protoc Immunol] 2016 Aug 01; Vol. 114, pp. 14.40.1-14.40.29. Date of Electronic Publication: 2016 Aug 01.