Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Thuy N Vien"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Neuroactive steroids (NASs) have potent anxiolytic, anticonvulsant, sedative, and hypnotic actions, that reflect in part their efficacy as GABAAR positive allosteric modulators (PAM). In addition to this, NAS exert metabotropic effects on GABAergic i
Externí odkaz:
https://doaj.org/article/1110699bf1494006862b88d33b2130ba
Autor:
Amit Modgil, Thuy N. Vien, Michael A. Ackley, James J. Doherty, Stephen J. Moss, Paul A. Davies
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. A reduction in neuronal inhibition mediated by γ-aminobutyric acid type A receptors (GABAARs) has been implicated in the pathophysiology of FXS. Neuroactive stero
Externí odkaz:
https://doaj.org/article/6dc66653188e4deb9833a7bba74d2f08
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Polycystins (PKD2, PKD2L1, and PKD2L2) are members of the transient receptor potential family, which form ciliary ion channels. Most notably, PKD2 dysregulation in the kidney nephron cilia is associated with polycystic kidney disease, but the functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab3badef2e44bdedd1a92d3d135e7a80
https://doi.org/10.1073/pnas.2219686120
https://doi.org/10.1073/pnas.2219686120
Autor:
Leo CT Ng, Brandon J Harris, Megan Larmore, My C Ta, Thuy N Vien, Valerie L Tokars, Vladimir Yarov‐Yarovoy, Paul G DeCaen
Publikováno v:
EMBO reports.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::172e9c97826c3fd5ecaed341a9c4ced2
https://doi.org/10.15252/embr.202356783
https://doi.org/10.15252/embr.202356783
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance How do variants that cause autosomal dominant polycystic kidney disease (ADPKD) alter the structure and function of polycystin-2 channels? This 20-y-old question remains unanswered because polycystins traffic to organelle membranes, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f09853b8416779579fa50a07f753e4c
http://europepmc.org/articles/PMC7229662
http://europepmc.org/articles/PMC7229662
Publikováno v:
Frontiers in molecular neuroscience. 15
Neuroactive steroids (NASs) have potent anxiolytic, anticonvulsant, sedative, and hypnotic actions, that reflect in part their efficacy as GABA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::50f3d7b34ee42406756833e9cfc802b2
https://pubmed.ncbi.nlm.nih.gov/35431797
https://pubmed.ncbi.nlm.nih.gov/35431797
Autor:
Megan M. McCollum, Megan Larmore, Shingo Ishihara, Leo C.T. Ng, Louise F. Kimura, Eduardo Guadarrama, My C. Ta, Thuy N. Vien, Grant B. Frost, Karl A. Scheidt, Rachel E. Miller, Paul G. DeCaen
Publikováno v:
Cell Rep
Voltage-gated sodium channels (Na(V)) in nociceptive neurons initiate action potentials required for transmission of aberrant painful stimuli observed in osteoarthritis (OA). Targeting these Na(V) subtypes with drugs to produce analgesic effects for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc420d0117415386d44a4713aaa2e597
https://pubmed.ncbi.nlm.nih.gov/36001977
https://pubmed.ncbi.nlm.nih.gov/36001977
Autor:
Paul Davies, Parakala Manasa Lakshmi, Yihui Zhang, Jayashree Chadchankar, James J. Doherty, Michael A. Ackley, Amit Modgil, Stephen J. Moss, Thuy N. Vien
Publikováno v:
J Biol Chem
Neuroactive steroids (NASs) are synthesized within the brain and exert profound effects on behavior. These effects are primarily believed to arise from the activities of NASs as positive allosteric modulators (PAMs) of the GABA-type A receptor (GABA(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8998724a42dcf842b52b322b5c598106
https://doi.org/10.1074/jbc.ra119.008875
https://doi.org/10.1074/jbc.ra119.008875
Publikováno v:
Proceedings of the National Academy of Sciences. 116:15540-15549
The opening of voltage-gated ion channels is initiated by transfer of gating charges that sense the electric field across the membrane. Although transient receptor potential ion channels (TRP) are members of this family, their opening is not intrinsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67b972d12436aa2e91a45657bad86c0c
https://doi.org/10.1073/pnas.1902917116
https://doi.org/10.1073/pnas.1902917116
Autor:
Thuy N, Vien, Leo C T, Ng, Jessica M, Smith, Ke, Dong, Matteus, Krappitz, Vladimir G, Gainullin, Sorin, Fedeles, Peter C, Harris, Stefan, Somlo, Paul G, DeCaen
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Approximately 15% of autosomal dominant polycystic kidney disease (ADPKD) is caused by variants in PKD2. PKD2 encodes polycystin-2, which forms an ion channel in primary cilia and endoplasmic reticulum (ER) membranes of renal collecting duct cells. E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e79f9690076b452b083a2e7eecaf5ee9
https://pubmed.ncbi.nlm.nih.gov/33199522
https://pubmed.ncbi.nlm.nih.gov/33199522