Methylthioadenosine reduces host inflammatory response by suppressing Salmonella virulence

Autor: James J. Gilchrist, Thurston Tlm, Jeffrey S. Bourgeois, Daoguo Zhou, Koa Dc

In order to deploy virulence factors at appropriate times and locations, microbes must rapidly sense and respond to various metabolite signals. Previously we showed transient elevation of the methionine-derived metabolite methylthioadenosine (MTA) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03bf7f984b0927945c7ed13c105fd997

CARD14 signalosome formation is associated with its endosomal relocation and mTORC1-induced keratinocyte proliferation.

Autor: O'Sullivan PA; The Francis Crick Institute, London NW1 1AT, U.K.; Institute of Immunity and Transplantation, University College London, London NW3 2PP, U.K., Aidarova A; VIB Center for Inflammation Research and Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Afonina IS; VIB Center for Inflammation Research and Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Manils J; The Francis Crick Institute, London NW1 1AT, U.K.; Institute of Immunity and Transplantation, University College London, London NW3 2PP, U.K.; Immunology Unit, Department of Pathology and Experimental Therapy, School of Medicine, University of Barcelona, Barcelona, Spain., Thurston TLM; MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, U.K., Instrell R; The Francis Crick Institute, London NW1 1AT, U.K., Howell M; The Francis Crick Institute, London NW1 1AT, U.K., Boeing S; The Francis Crick Institute, London NW1 1AT, U.K., Ranawana S; Institute of Immunity and Transplantation, University College London, London NW3 2PP, U.K., Herpels MB; Institute of Immunity and Transplantation, University College London, London NW3 2PP, U.K., Chetian R; Institute of Immunity and Transplantation, University College London, London NW3 2PP, U.K., Bassa M; Institute of Immunity and Transplantation, University College London, London NW3 2PP, U.K., Flynn H; The Francis Crick Institute, London NW1 1AT, U.K., Frith D; The Francis Crick Institute, London NW1 1AT, U.K., Snijders AP; The Francis Crick Institute, London NW1 1AT, U.K., Howes A; National Heart and Lung Institute, Imperial College London, London W12 0NN, U.K., Beyaert R; VIB Center for Inflammation Research and Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Bowcock AM; Department of Oncological Science, Dermatology, and Genetics and Genome Sciences, Icahn School of Medicine at Mount Sinai, New York 10029, U.S.A., Ley SC; Institute of Immunity and Transplantation, University College London, London NW3 2PP, U.K.

Publikováno v: The Biochemical journal [Biochem J] 2024 Sep 18; Vol. 481 (18), pp. 1143-1171.

Modulation of Salmonella virulence by a novel SPI-2 injectisome effector that interacts with the dystrophin-associated protein complex.

Autor: Yu X-J; Department of Infectious Disease, Centre for Bacterial Resistance Biology, Imperial College London, London, United Kingdom., Xie H; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, China., Li Y; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., Liu M; Department of Infectious Disease, Centre for Bacterial Resistance Biology, Imperial College London, London, United Kingdom., Hou R; Department of Infectious Disease, Centre for Bacterial Resistance Biology, Imperial College London, London, United Kingdom., Predeus AV; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., Perez Sepulveda BM; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., Hinton JCD; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., Holden DW; Department of Infectious Disease, Centre for Bacterial Resistance Biology, Imperial College London, London, United Kingdom., Thurston TLM; Department of Infectious Disease, Centre for Bacterial Resistance Biology, Imperial College London, London, United Kingdom.

Publikováno v: MBio [mBio] 2024 Jul 17; Vol. 15 (7), pp. e0112824. Date of Electronic Publication: 2024 Jun 21.

A single amino acid in the Salmonella effector SarA/SteE triggers supraphysiological activation of STAT3 for anti-inflammatory target gene expression.

Autor: Gaggioli MR; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA., Jones AG; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA., Panagi I; Department of Infectious Disease, Centre for Bacterial Resistance Biology, Imperial College London, London, UK., Washington EJ; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA.; Department of Biochemistry, School of Medicine, Duke University, Durham, NC 27710, USA., Loney RE; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA., Muench JH; The Francis Crick Institute, London NW1 1AT, UK., Brennan RG; Department of Biochemistry, School of Medicine, Duke University, Durham, NC 27710, USA., Thurston TLM; Department of Infectious Disease, Centre for Bacterial Resistance Biology, Imperial College London, London, UK., Ko DC; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA.; Division of Infectious Diseases, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA.; Lead contact.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 14. Date of Electronic Publication: 2024 Feb 14.

The Salmonella Typhi SPI-2 injectisome enigma.

Autor: Thurston TLM; Department of Infectious Disease, Centre for Bacterial Resistance Biology, Imperial College London, London, SW7 2AZ, UK., Holden DW; Department of Infectious Disease, Centre for Bacterial Resistance Biology, Imperial College London, London, SW7 2AZ, UK.

Publikováno v: Microbiology (Reading, England) [Microbiology (Reading)] 2023 Oct; Vol. 169 (10).