Combined histone deacetylase inhibition and tamoxifen induces apoptosis in tamoxifen resistant breast cancer models, by reversing Bcl-2 overexpression

Autor: Raha, P, Thomas, S, Thurn, KT, Park, J, Munster, PN

Publikováno v: Breast cancer research : BCR, vol 17, iss 1

INTRODUCTION: The emergence of hormone therapy resistance, despite continued expression of the estrogen receptor (ER), is a major challenge to curing breast cancer. Recent clinical studies suggest that epigenetic modulation by histone deacetylase (HD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9fc94378afb8fecb9912c8202b81bafb
https://escholarship.org/uc/item/6nw18482

A phase I trial of panobinostat and epirubicin in solid tumors with a dose expansion in patients with sarcoma.

Autor: Thomas S; Department of Medicine/Hematology and Oncology, University of California, San Francisco, San Francisco, USA., Aggarwal R; Department of Medicine/Hematology and Oncology, University of California, San Francisco, San Francisco, USA., Jahan T; Department of Medicine/Hematology and Oncology, University of California, San Francisco, San Francisco, USA., Ryan C; Department of Medicine/Hematology and Oncology, University of California, San Francisco, San Francisco, USA., Troung T; Department of Medicine/Hematology and Oncology, University of California, San Francisco, San Francisco, USA., Cripps AM; Department of Medicine/Hematology and Oncology, University of California, San Francisco, San Francisco, USA., Raha P; Department of Medicine/Hematology and Oncology, University of California, San Francisco, San Francisco, USA., Thurn KT; Department of Medicine/Hematology and Oncology, University of California, San Francisco, San Francisco, USA., Chen S; Department of Medicine/Hematology and Oncology, University of California, San Francisco, San Francisco, USA., Grabowsky JA; Department of Medicine/Hematology and Oncology, University of California, San Francisco, San Francisco, USA., Park J; Department of Medicine/Hematology and Oncology, University of California, San Francisco, San Francisco, USA., Hwang J; Department of Medicine/Hematology and Oncology, University of California, San Francisco, San Francisco, USA., Daud A; Department of Medicine/Hematology and Oncology, University of California, San Francisco, San Francisco, USA., Munster PN; Department of Medicine/Hematology and Oncology, University of California, San Francisco, San Francisco, USA pamela.munster@ucsf.edu.

Publikováno v: Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2016 May; Vol. 27 (5), pp. 947-52. Date of Electronic Publication: 2016 Feb 21.

Histone deacetylase regulation of ATM-mediated DNA damage signaling.

Autor: Thurn KT; Corresponding Author: Pamela N. Munster, Division of Hematology and Oncology, Department of Medicine, University of California, 1600 Divisadero, Room A719, Box 1711, San Francisco, CA 94143. pmunster@medicine.ucsf.edu., Thomas S, Raha P, Qureshi I, Munster PN

Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2013 Oct; Vol. 12 (10), pp. 2078-87. Date of Electronic Publication: 2013 Aug 12.

Addition of a histone deacetylase inhibitor redirects tamoxifen-treated breast cancer cells into apoptosis, which is opposed by the induction of autophagy.

Autor: Thomas S; Division of Hematology and Oncology, University of California, San Francisco, CA 94143, USA., Thurn KT, Biçaku E, Marchion DC, Münster PN

Publikováno v: Breast cancer research and treatment [Breast Cancer Res Treat] 2011 Nov; Vol. 130 (2), pp. 437-47. Date of Electronic Publication: 2011 Feb 05.

Endocytosis of titanium dioxide nanoparticles in prostate cancer PC-3M cells.

Autor: Thurn KT; Department of Radiation Oncology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA., Arora H, Paunesku T, Wu A, Brown EM, Doty C, Kremer J, Woloschak G

Publikováno v: Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2011 Apr; Vol. 7 (2), pp. 123-30. Date of Electronic Publication: 2010 Sep 29.