Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Thurl E. Harris"'
Autor:
Andrew J. Heindel, Jeffrey W. Brulet, Xiantao Wang, Michael W. Founds, Adam H. Libby, Dina L. Bai, Michael C. Lemke, David M. Leace, Thurl E. Harris, Markus Hafner, Ku-Lung Hsu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Proteomic methods for RNA interactome capture (RIC) rely principally on crosslinking native or labeled cellular RNA to enrich and investigate RNA-binding protein (RBP) composition and function in cells. The ability to measure RBP activity at
Externí odkaz:
https://doaj.org/article/04e8d79101f84503b966141edfd09c6e
Autor:
Mitchell E. Granade, Stefan R. Hargett, Daniel S. Lank, Michael C. Lemke, Melissa A. Luse, Brant E. Isakson, Irina M. Bochkis, Joel Linden, Thurl E. Harris
Publikováno v:
Molecular Metabolism, Vol 63, Iss , Pp 101543- (2022)
Objective: Adipose tissue is a critical regulator of energy balance that must rapidly shift its metabolism between fasting and feeding to maintain homeostasis. Adenosine has been characterized as an important regulator of adipocyte metabolism primari
Externí odkaz:
https://doaj.org/article/4d0f181c11f14a62817560bbc6f02485
Autor:
Laryssa C. Manigat, Mitchell E. Granade, Suchet Taori, Charlotte Anne Miller, Luke R. Vass, Xiao-Ping Zhong, Thurl E. Harris, Benjamin W. Purow
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The diacylglycerol kinases (DGKs) are a family of enzymes responsible for the conversion of diacylglycerol (DAG) to phosphatidic acid (PA). In addition to their primary function in lipid metabolism, DGKs have recently been identified as potential the
Externí odkaz:
https://doaj.org/article/5ba88728e8134ec2bb0acf93d24cdecf
Autor:
Huan Wang, Tracey W. Chan, Ajay A. Vashisht, Brian G. Drew, Anna C. Calkin, Thurl E. Harris, James A. Wohlschlegel, Xinshu Xiao, Karen Reue
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
Lipin 1 regulates cellular lipid homeostasis through roles in glycerolipid synthesis (through phosphatidic acid phosphatase activity) and transcriptional coactivation. Lipin 1–deficient individuals exhibit episodic disease symptoms that are trigger
Externí odkaz:
https://doaj.org/article/1ff759e379464c57a35ea1198f97e92c
Autor:
Supreet Kaur, Christopher Auger, Dalia Barayan, Priyal Shah, Anna Matveev, Carly M. Knuth, Thurl E. Harris, Marc G. Jeschke
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 6, Pp n/a-n/a (2021)
Abstract Hypermetabolism following severe burn injuries is associated with adipocyte dysfunction, elevated beige adipocyte formation, and increased energy expenditure. The resulting catabolism of adipose leads to detrimental sequelae such as fatty li
Externí odkaz:
https://doaj.org/article/49d63209710d49869a903e83f5759917
Reduced adiponectin levels in patients with COVID‐19 acute respiratory failure: A case‐control study
Autor:
Sean M. Kearns, Katelyn W. Ahern, James T. Patrie, William B. Horton, Thurl E. Harris, Alexandra Kadl
Publikováno v:
Physiological Reports, Vol 9, Iss 7, Pp n/a-n/a (2021)
Abstract Hypoadiponectinemia is speculated to play a key role in the relationship between obesity and COVID‐19 respiratory failure. However, only one study has examined adiponectin levels in COVID‐19 patients, and none have investigated adiponect
Externí odkaz:
https://doaj.org/article/6e093c4878c74d359d20e9c9fa91d1b2
Autor:
Subramanian Senthivinayagam, Vlad Serbulea, Clint M. Upchurch, Renata Polanowska-Grabowska, Suresh K. Mendu, Srabani Sahu, Prathiba Jayaguru, Kevin W. Aylor, Mahendra D. Chordia, Limor Steinberg, Nathaniel Oberholtzer, Seichii Uchiyama, Noriko Inada, Ulrike M. Lorenz, Thurl E. Harris, Susanna R. Keller, Akshaya K. Meher, Alexandra Kadl, Bimal N. Desai, Bijoy K. Kundu, Norbert Leitinger
Publikováno v:
Molecular Metabolism, Vol 44, Iss , Pp 101130- (2021)
Objective: Brown adipose tissue (BAT) is specialized in thermogenesis. The conversion of energy into heat in brown adipocytes proceeds via stimulation of β-adrenergic receptor (βAR)-dependent signaling and activation of mitochondrial uncoupling pro
Externí odkaz:
https://doaj.org/article/3bac5da2881d485a8632564ecf041a48
Autor:
Vlad Serbulea, Clint M. Upchurch, Katelyn W. Ahern, Gael Bories, Paxton Voigt, Dory E. DeWeese, Akshaya K. Meher, Thurl E. Harris, Norbert Leitinger
Publikováno v:
Molecular Metabolism, Vol 7, Iss , Pp 23-34 (2018)
Objective: Macrophages control tissue homeostasis and inflammation by sensing and responding to environmental cues. However, the metabolic adaptation of macrophages to oxidative tissue damage and its translation into inflammatory mechanisms remains e
Externí odkaz:
https://doaj.org/article/a70635b001c540ebbfabf86f68213458
Autor:
Evan P. Taddeo, Stefan R. Hargett, Sujoy Lahiri, Marin E. Nelson, Jason A. Liao, Chien Li, Jill K. Slack-Davis, Jose L. Tomsig, Kevin R. Lynch, Zhen Yan, Thurl E. Harris, Kyle L. Hoehn
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Hepatic glucose production (HGP) is required to maintain normoglycemia during fasting. Glucagon is the primary hormone responsible for increasing HGP; however, there are many additional hormone and metabolic factors that influence glucagon s
Externí odkaz:
https://doaj.org/article/e280b7810e98472f94e89b5b849f2537
Autor:
Martin Pagac, Daniel E. Cooper, Yanfei Qi, Ivan E. Lukmantara, Hoi Yin Mak, Zengying Wu, Yuan Tian, Zhonghua Liu, Mona Lei, Ximing Du, Charles Ferguson, Damian Kotevski, Pawel Sadowski, Weiqin Chen, Salome Boroda, Thurl E. Harris, George Liu, Robert G. Parton, Xun Huang, Rosalind A. Coleman, Hongyuan Yang
Publikováno v:
Cell Reports, Vol 17, Iss 6, Pp 1546-1559 (2016)
Berardinelli-Seip congenital lipodystrophy 2 (BSCL2) is caused by loss-of-function mutations in SEIPIN, a protein implicated in both adipogenesis and lipid droplet expansion but whose molecular function remains obscure. Here, we identify physical and
Externí odkaz:
https://doaj.org/article/bba742076e6a484f95bec3c954f64b30