Bedaquiline and clofazimine resistance in Mycobacterium tuberculosis: an in-vitro and in-silico data analysis

Autor: Sonnenkalb, L, Carter, JJ, Spitaleri, A, Iqbal, Z, Hunt, M, Malone, KM, Utpatel, C, Cirillo, DM, Rodrigues, C, Nilgiriwala, KS, Fowler, PW, Merker, M, Niemann, S, Barilar, I, Battaglia, S, Borroni, E, Brandao, AP, Brankin, A, Cabibbe, AM, Carter, J, Claxton, P, Clifton, DA, Cohen, T, Coronel, J, Crook, DW, Dreyer, V, Earle, SG, Escuyer, V, Ferrazoli, L, Fu Gao, G, Gardy, J, Gharbia, S, Ghisi, KT, Ghodousi, A, Gibertoni Cruz, AL, Grandjean, L, Grazian, C, Groenheit, R, Guthrie, JL, He, W, Hoffmann, H, Hoosdally, SJ, Ismail, NA, Jarrett, L, Joseph, L, Jou, R, Kambli, P, Khot, R, Knaggs, J, Koch, A, Kohlerschmidt, D, Kouchaki, S, Lachapelle, AS, Lalvani, A, Grandjean Lapierre, S, Laurenson, IF, Letcher, B, Lin, W-H, Liu, C, Liu, D, Mandal, A, Mansjö, M, Matias, D, Meintjes, G, De Freitas Mendes, F, Mihalic, M, Millard, J, Miotto, P, Mistry, N, Moore, D, Musser, KA, Ngcamu, D, Hoang, NN, Nimmo, C, Okozi, N, Oliveira, RS, Omar, SV, Paton, N, Peto, TEA, Watanabe Pinhata, JM, Plesnik, S, Puyen, ZM, Rabodoarivelo, MS, Rakotosamimanana, N, Rancoita, PMV, Rathod, P, Rodger, G, Rodwell, TC, Roohi, E, Santos-Lazaro, D, Shah, S, Kohl, TA, Smith, G, Solano, W, Supply, P, Surve, U, Tahseen, S, Thuong, NTT, Thwaites, G, Todt, K, Trovato, A, Van Rie, A, Vijay, S, Walker, TM, Walker, SA, Warren, R, Werngren, J, Wijkander, M, Wilkinson, RJ, Wilson, DJ, Wintringer, P, Yu, XX, Yang, Y, Zhao, Y, Yao, S-Y, Zhu, B

Publikováno v: e368
e358

Background Bedaquiline is a core drug for the treatment of multidrug-resistant tuberculosis; however, the understanding of resistance mechanisms is poor, which is hampering rapid molecular diagnostics. Some bedaquiline-resistant mutants are also cros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d2c6f478af9f451ce02ba6c6ec516b
https://doi.org/10.1016/s2666-5247(23)00002-2

Bedaquiline and clofazimine resistance in Mycobacterium tuberculosis: an in-vitro and in-silico data analysis

Autor: Sonnenkalb, Lindsay, Carter, Joshua James, Spitaleri, Andrea, Iqbal, Zamin, Hunt, Martin, Malone, Kerri Marie, Utpatel, Christian, Cirillo, Daniela Maria, Rodrigues, Camilla, Nilgiriwala, Kayzad Soli, Fowler, Philip William, Merker, Matthias, Niemann, Stefan, Consortium, The Comprehensive Resistance Prediction for Tuberculosis: an International, Barilar, I, Battaglia, S, Borroni, E, Brandao, AP, Brankin, A, Cabibbe, AM, Carter, J, Claxton, P, Clifton, DA, Cohen, T, Coronel, J, Crook, DW, Dreyer, V, Earle, SG, Escuyer, V, Ferrazoli, L, Fowler, PW, Gao, G Fu, Gardy, J, Gharbia, S, Ghisi, KT, Ghodousi, A, Cruz, AL Gibertoni, Grandjean, L, Grazian, C, Groenheit, R, Guthrie, JL, He, W, Hoffmann, H, Hoosdally, SJ, Ismail, NA, Jarrett, L, Joseph, L, Jou, R, Kambli, P, Khot, R, Knaggs, J, Koch, A, Kohlerschmidt, D, Kouchaki, S, Lachapelle, AS, Lalvani, A, Lapierre, S Grandjean, Laurenson, IF, Letcher, B, Lin, WH, Liu, C, Liu, D, Malone, KM, Mandal, A, Mansjö, M, Matias, D, Meintjes, G, de Freitas Mendes, F, Mihalic, M, Millard, J, Miotto, P, Mistry, N, Moore, D, Musser, KA, Ngcamu, D, Hoang, NN, Nimmo, C, Okozi, N, Oliveira, RS, Omar, SV, Paton, N, Peto, TE, Pinhata, JM Watanabe, Plesnik, S, Puyen, ZM, Rabodoarivelo, MS, Rakotosamimanana, N, Rancoita, PM, Rathod, P, Rodger, G, Rodwell, TC, Roohi, E, Santos-Lazaro, D, Shah, S, Kohl, TA, Smith, G, Solano, W, Supply, P, Surve, U, Tahseen, S, Thuong, NTT

Background: Bedaquiline is a core drug for the treatment of multidrug-resistant tuberculosis; however, the understanding of resistance mechanisms is poor, which is hampering rapid molecular diagnostics. Some bedaquiline-resistant mutants are also cro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3dc1aaf8f396193628850666e402b6

Host directed therapies for tuberculous meningitis [version 2; peer review: 1 approved, 1 approved with reservations]

Autor: Davis, A, Donovan, J, Bremer, M, Van Toorn, R, Schoeman, J, Dadabhoy, A, Lai, RPJ, Cresswell, F, Boulware, D, Wilkinson, R, Thuong, NTT, Thwaites, G, Bahr, N, Tuberculous Meningitis International Research Consortium

A dysregulated host immune response significantly contributes to morbidity and mortality in tuberculous meningitis (TBM). Effective host directed therapies (HDTs) are critical to improve survival and clinical outcomes. Currently only one HDT, dexamet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::85bfb801c28e459c3dae1a8f59d6f598
http://hdl.handle.net/10044/1/91356

Diagnostic Cerebrospinal Fluid Biomarker Discovery and Validation in Patients with Central Nervous System Infections

Autor: Chau Nvv., Chau Ltm., Du Trong Duc, Nguyen Hoan Phu, Hong Ntt., Climent Casals-Pascual, Ngo Thi Hoa, Tran Tan Thanh, Thu Dda., Thuong Ntt., Nghiem My Ngoc, Ronald B. Geskus, Oanh Pkn., Hanh Nhh., Nghia Hdt., P N Uyen, Hanh Btb., V B Ngoc, Le Van Tan, Le Thi Diem, Roman Fischer, Guy E. Thwaites, Ny Nth., Van Xuan Quynh, Benedikt M. Kessler, Nhu Lnt., Hang Vtt.

BackgroundCentral nervous system (CNS) infections are common causes of morbidity and mortality worldwide. Rapid, accurate identification of the likely cause is essential for clinical management and the early initiation of antimicrobial therapy, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b8ee7e228f20e6f4cc17ed25bd27f5

Recent developments in Tuberculous meningitis pathogenesis and diagnostics [version 2; peer review: 1 approved]

Autor: Cresswell, F, Davis, A, Sharma, K, Basu Roy, R, Ganiem, AR, Kagimu, E, Solomons, R, Wilkinson, R, Bahr, N, Thuong, NTT, Tuberculous Meningitis International Research Consortium

The pathogenesis of Tuberculous meningitis (TBM) is poorly understood, but contemporary molecular biology technologies have allowed for recent improvements in our understanding of TBM. For instance, neutrophils appear to play a significant role in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::7db4f5598739e89e28fafa0ec4e7a681
http://hdl.handle.net/10044/1/82707