GenomegaMap: within-species genome-widedN/dSestimation from over 10,000 genomes

Autor: Wilson, DJ, Crook, DW, Peto, TEA, Walker, AS, Hoosdally, SJ, Gibertoni Cruz, AL, Carter, J, Grazian, C, Earle, SG, Kouchaki, S, Lachapelle, A, Yang, Y, Clifton, DA, Fowler, PW, Iqbal, Z, Hunt, M, Knaggs, J, Smith, EG, Rathod, P, Jarrett, L, Matias, D, Cirillo, DM, Borroni, E, Battaglia, S, Ghodousi, A, Spitaleri, A, Cabibbe, A, Tahseen, S, Nilgiriwala, K, Shah, S, Rodrigues, C, Kambli, P, Surve, U, Khot, R, Niemann, S, Kohl, TA, Merker, M, Hoffmann, H, Todt, K, Plesnik, S, Ismail, N, Omar, SV, Joseph, L, Thwaites, G, Thuong, TNT, Ngoc, NH, Srinivasan, V, Walker, TM, Moore, D, Coronel, J, Solano, W, Gao, GF, He, G, Zhao, Y, Liu, C, Ma, A, Zhu, B, Laurenson, I, Claxton, P, Koch, A, Wilkinson, R, Lalvani, A, Posey, J, Gardy, J, Werngren, J, Paton, N, Jou, R, Wu, M-H, Lin, W-H, Ferrazoli, L, De Oliveira, RS, Arandjelovic, I, Chaiprasert, A, Comas, I, Roig, CJ, Drobniewski, FA, Farhat, MR, Gao, Q, Hee, ROT, Sintchenko, V, Supply, P, Van Soolingen, D

Publikováno v: Molecular Biology and Evolution
Molecular Biology and Evolution, 2020, 37 (8), pp.2450-2460. ⟨10.1093/molbev/msaa069⟩
Molecular Biology and Evolution, Oxford University Press (OUP), 2020, 37 (8), pp.2450-2460. ⟨10.1093/molbev/msaa069⟩
Digital.CSIC. Repositorio Institucional del CSIC
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11 págs, 4 figuras y fórmulas matemáticas. Material suplementario en: http://dx.doi.org/10.1093/molbev/msaa069
The dN/dS ratio provides evidence of adaptation or functional constraint in protein-coding genes by quantifying the relative excess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f28734013613db456521c1a9a29560
https://doi.org/10.1101/523316

Developing biomarker assays to accelerate tuberculosis drug development: defining target product profiles.

Autor: Gillespie SH; Division of Infection and Global Health, School of Medicine, University of St Andrews, St Andrews, UK. Electronic address: shg3@st-andrews.ac.uk., DiNardo AR; Global TB Program, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, GA Nijmegen, Netherlands., Georghiou SB; FIND, Campus Biotech, Geneva, Switzerland., Sabiiti W; Division of Infection and Global Health, School of Medicine, University of St Andrews, St Andrews, UK., Kohli M; FIND, Campus Biotech, Geneva, Switzerland., Panzner U; Division of Infectious Diseases and Tropical Medicine, University Hospital, Ludwig-Maximilians-Universität München (LMU), Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany., Kontsevaya I; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany; Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK., Hittel N; Janssen Global Public Health R&D, Janssen Pharmaceutica NV, Beerse, Belgium., Stuyver LJ; Otsuka Novel Products, Munich, Germany., Tan JB; FIND, Campus Biotech, Geneva, Switzerland., van Crevel R; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, GA Nijmegen, Netherlands; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Lange C; Global TB Program, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA; Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany; German Center for Infection Research (DZIF), Clinical Tuberculosis Unit, Borstel, Germany; Respiratory Medicine & International Health, University of Lübeck, Lübeck, Germany., Thuong TNT; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam., Heyckendorf J; Respiratory Medicine & International Health, University of Lübeck, Lübeck, Germany; Clinic for Internal Medicine I, University Hospital Schleswig-Holstein (UKSH) Campus Kiel, Kiel, Germany., Ruhwald M; FIND, Campus Biotech, Geneva, Switzerland., Heinrich N; Division of Infectious Diseases and Tropical Medicine, University Hospital, Ludwig-Maximilians-Universität München (LMU), Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, Munich, Germany.

Publikováno v: The Lancet. Microbe [Lancet Microbe] 2024 Sep; Vol. 5 (9), pp. 100869. Date of Electronic Publication: 2024 May 09.

Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing.

Autor: Allix-Béguec C, Arandjelovic I, Bi L, Beckert P, Bonnet M, Bradley P, Cabibbe AM, Cancino-Muñoz I, Caulfield MJ, Chaiprasert A, Cirillo DM, Clifton DA, Comas I, Crook DW, De Filippo MR, de Neeling H, Diel R, Drobniewski FA, Faksri K, Farhat MR, Fleming J, Fowler P, Fowler TA, Gao Q, Gardy J, Gascoyne-Binzi D, Gibertoni-Cruz AL, Gil-Brusola A, Golubchik T, Gonzalo X, Grandjean L, He G, Guthrie JL, Hoosdally S, Hunt M, Iqbal Z, Ismail N, Johnston J, Khanzada FM, Khor CC, Kohl TA, Kong C, Lipworth S, Liu Q, Maphalala G, Martinez E, Mathys V, Merker M, Miotto P, Mistry N, Moore DAJ, Murray M, Niemann S, Omar SV, Ong RT, Peto TEA, Posey JE, Prammananan T, Pym A, Rodrigues C, Rodrigues M, Rodwell T, Rossolini GM, Sánchez Padilla E, Schito M, Shen X, Shendure J, Sintchenko V, Sloutsky A, Smith EG, Snyder M, Soetaert K, Starks AM, Supply P, Suriyapol P, Tahseen S, Tang P, Teo YY, Thuong TNT, Thwaites G, Tortoli E, van Soolingen D, Walker AS, Walker TM, Wilcox M, Wilson DJ, Wyllie D, Yang Y, Zhang H, Zhao Y, Zhu B

Publikováno v: The New England journal of medicine [N Engl J Med] 2018 Oct 11; Vol. 379 (15), pp. 1403-1415. Date of Electronic Publication: 2018 Sep 26.