Zobrazeno 1 - 10
of 465
pro vyhledávání: '"Thumbi Ndung'u"'
Autor:
Tanvir Hossain, Cynthia Lungu, Sten de Schrijver, Mamokoena Kuali, Raquel Crespo, Nicole Reddy, Ayanda Ngubane, Tsung Wai Kan, Kavidha Reddy, Shringar Rao, Robert-Jan Palstra, Paradise Madlala, Thumbi Ndung’u, Tokameh Mahmoudi
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-16 (2024)
Abstract Background Strategies toward HIV-1 cure aim to clear, inactivate, reduce, or immunologically control the virus from a pool of latently infected cells such that combination antiretroviral therapy (cART) can be safely interrupted. In order to
Externí odkaz:
https://doaj.org/article/96ec68967979482ebfb2e9618aa6e80f
Autor:
Maphe Mthembu, Helgard Claassen, Sharon Khuzwayo, Valentin Voillet, Anneta Naidoo, Jule S. Spillner, Kennedy Nyamande, Dilshaad Fakey Khan, Priya Maharaj, Mohammed Mitha, Zoey Mhlane, Farina Karim, Erica Andersen-Nissen, Thumbi Ndung’u, Gabriele Pollara, Emily B. Wong
Publikováno v:
iScience, Vol 27, Iss 11, Pp 111137- (2024)
Summary: HIV causes susceptibility to respiratory pathogens, including tuberculosis (TB), but the underlying immunological mechanisms remain incompletely understood. We obtained whole blood and bronchoalveolar lavage (BAL) from TB-exposed people in t
Externí odkaz:
https://doaj.org/article/56b137e67153442bab5a1ed3b3f5968e
Autor:
Steven A. Kemp, Kimia Kamelian, Diego F. Cuadros, PANGEA Consortium, Vukuzazi Team, Mark T. K. Cheng, Elphas Okango, Willem Hanekom, Thumbi Ndung’u, Deenan Pillay, David Bonsall, Emily B. Wong, Frank Tanser, Mark J. Siedner, Ravindra K. Gupta
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Despite expanded antiretroviral therapy (ART) in South Africa, HIV-1 transmission persists. Integrase strand transfer inhibitors (INSTI) and long-acting injectables offer potential for superior viral suppression, but pre-existing drug resist
Externí odkaz:
https://doaj.org/article/89c0e3f21d6f4594a986118e896f7a66
Autor:
Nelson Sonela, Jaclyn Mann, Celestin Godwe, Oumarou H. Goni, Mérime Tchakoute, Nathalie Nkoue, Tulio de Oliveira, Mark A. Brockman, Zabrina L. Brumme, Thumbi Ndung’u, Marcel Tongo
Publikováno v:
Frontiers in Virology, Vol 4 (2024)
HIV-1 group M (HIV-1M) lineages downregulate HLA-I and CD4 expression via their Nef proteins. We hypothesized that these Nef functions may be partially responsible for the differences in prevalence of viruses from different lineages that co-circulate
Externí odkaz:
https://doaj.org/article/b41d94ab929d4855a86f2ab52eee7a0e
Publikováno v:
Journal of Virus Eradication, Vol 10, Iss 1, Pp 100364- (2024)
While low- and middle-income countries (LMICs), especially in Southern and Eastern Africa, bear the largest burden of the HIV globally, investigators working on the front lines in these regions are leading a limited number of research efforts, partic
Externí odkaz:
https://doaj.org/article/f9864f478af9409a994a700df9b64374
Autor:
Victoria O. Kasprowicz, Caroline Jeffery, Dorcas Mbuvi, Victoria Bukirwa, Karim Ouattara, Florence Kirimi, Kathrin Heitz-Tokpa, Mary Gorrethy, Denis Chopera, Damalie Nakanjako, Bassirou Bonfoh, Alison Elliott, Samson Kinyanjui, Imelda Bates, Thumbi Ndung’u
Publikováno v:
Health Research Policy and Systems, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Recent efforts to shift the control and leadership of health research on African issues to Africa have led to increased investments for scientific research capacity strengthening (RCS) on the continent and a greater demand for accountability
Externí odkaz:
https://doaj.org/article/2c81027811474760a55ffda1f9e99227
Autor:
Thumbi Ndung’u
Publikováno v:
Retrovirology, Vol 20, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/48542c37438e4ad9a763672669058587
Autor:
Lynn Fwambah, Cheryl Andisi, Claire Streatfield, Rachel Bromell, Jonathan Hare, Joakim Esbjörnsson, Thumbi Ndung’u, Eduard J. Sanders, Amin S. Hassan, Eunice Nduati
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionThe impact of exposure to endemic infections on basal immunity and susceptibility to HIV-1 acquisition remains uncertain. We hypothesized that exposure to infections such as cytomegalovirus (CMV), malaria and sexually transmitted infectio
Externí odkaz:
https://doaj.org/article/1dd29904d4a44853b882b35c4beaf3da
Autor:
Amelia M Stanton, Ryan L Boyd, Conall O'Cleirigh, Stephen Olivier, Brett Dolotina, Resign Gunda, Olivier Koole, Dickman Gareta, Tshwaraganang H Modise, Zahra Reynolds, Thandeka Khoza, Kobus Herbst, Thumbi Ndung'u, Willem A Hanekom, Emily B Wong, Deenan Pillay, Mark J Siedner, Vukuzazi Study Team
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0293963 (2024)
Health-related quality of life (HRQoL) assesses the perceived impact of health status across life domains. Although research has explored the relationship between specific conditions, including HIV, and HRQoL in low-resource settings, less attention
Externí odkaz:
https://doaj.org/article/bae81b677fe848d585875e46ceef0345
Autor:
Delon Naicker, Nelson Sonela, Steven W. Jin, Takalani Mulaudzi, Doty Ojwach, Tarylee Reddy, Mark A. Brockman, Zabrina L. Brumme, Thumbi Ndung’u, Jaclyn K. Mann
Publikováno v:
Retrovirology, Vol 20, Iss 1, Pp 1-14 (2023)
Abstract Background Nef performs multiple cellular activities that enhance HIV-1 pathogenesis. The role of Nef-mediated down-regulation of the host restriction factor SERINC5 in HIV-1 pathogenesis is not well-defined. We aimed to investigate if SERIN
Externí odkaz:
https://doaj.org/article/aaf7e0dd96024dff8b8017b33d8e22dd