Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Thuc M. Le"'
Autor:
Evan R. Abt, Khalid Rashid, Thuc M. Le, Suwen Li, Hailey R. Lee, Vincent Lok, Luyi Li, Amanda L. Creech, Amanda N. Labora, Hanna K. Mandl, Alex K. Lam, Arthur Cho, Valerie Rezek, Nanping Wu, Gabriel Abril-Rodriguez, Ethan W. Rosser, Steven D. Mittelman, Willy Hugo, Thomas Mehrling, Shanta Bantia, Antoni Ribas, Timothy R. Donahue, Gay M. Crooks, Ting-Ting Wu, Caius G. Radu
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 16 (2022)
Purine nucleoside phosphorylase (PNP) enables the breakdown and recycling of guanine nucleosides. PNP insufficiency in humans is paradoxically associated with both immunodeficiency and autoimmunity, but the mechanistic basis for these outcomes is inc
Externí odkaz:
https://doaj.org/article/e438254920ee4e73ba0fa35c8e36bf84
Autor:
Shen Li, Tomohiro Yokota, Ping Wang, Johanna ten Hoeve, Feiyang Ma, Thuc M. Le, Evan R. Abt, Yonggang Zhou, Rimao Wu, Maxine Nanthavongdouangsy, Abraham Rodriguez, Yijie Wang, Yen-Ju Lin, Hayato Muranaka, Mark Sharpley, Demetrios T. Braddock, Vicky E. MacRae, Utpal Banerjee, Pei-Yu Chiou, Marcus Seldin, Dian Huang, Michael Teitell, Ilya Gertsman, Michael Jung, Steven J. Bensinger, Robert Damoiseaux, Kym Faull, Matteo Pellegrini, Aldons J. Lusis, Thomas G. Graeber, Caius G. Radu, Arjun Deb
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)
Various populations of cells are recruited to the heart after cardiac injury, but little is known about whether cardiomyocytes directly regulate heart repair. Using a murine model of ischemic cardiac injury, we demonstrate that cardiomyocytes play a
Externí odkaz:
https://doaj.org/article/4f249dd668874f6a904b120bd8b43144
Autor:
Matthew Garrett, Jantzen Sperry, Daniel Braas, Weihong Yan, Thuc M. Le, Jack Mottahedeh, Kirsten Ludwig, Ascia Eskin, Yue Qin, Rachelle Levy, Joshua J. Breunig, Frank Pajonk, Thomas G. Graeber, Caius G. Radu, Heather Christofk, Robert M. Prins, Albert Lai, Linda M. Liau, Giovanni Coppola, Harley I. Kornblum
Publikováno v:
Cancer & Metabolism, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract Background There is considerable interest in defining the metabolic abnormalities of IDH mutant tumors to exploit for therapy. While most studies have attempted to discern function by using cell lines transduced with exogenous IDH mutant enz
Externí odkaz:
https://doaj.org/article/642fab9d621f45ce80bff09ea33cbe6b
Autor:
Thuc M. Le, Soumya Poddar, Joseph R. Capri, Evan R. Abt, Woosuk Kim, Liu Wei, Nhu T. Uong, Chloe M. Cheng, Daniel Braas, Mina Nikanjam, Peter Rix, Daria Merkurjev, Jesse Zaretsky, Harley I. Kornblum, Antoni Ribas, Harvey R. Herschman, Julian Whitelegge, Kym F. Faull, Timothy R. Donahue, Johannes Czernin, Caius G. Radu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Leukemic cells depend on the nucleotide synthesis pathway to proliferate. Here the authors use metabolomics and proteomics to show that inhibition of ATR reduced the activity of these pathways thus providing a valuable therapeutic target in leukemia.
Externí odkaz:
https://doaj.org/article/ea735642f5484b8db7d0f34fe2f452fc
Autor:
Bao Ying Chen, Jessica R. Salas, Alyssa O. Trias, Arely Perez Rodriguez, Jonathan E. Tsang, Miriam Guemes, Thuc M. Le, Zoran Galic, H. Michael Shepard, Lawrence Steinman, David A. Nathanson, Johannes Czernin, Owen N. Witte, Caius G. Radu, Kenneth A. Schultz, Peter M. Clark
Publikováno v:
Immunology. 168:152-169
Multiple sclerosis (MS) is an autoimmune disease driven by lymphocyte activation against myelin autoantigens in the central nervous system leading to demyelination and neurodegeneration. The deoxyribonucleoside salvage pathway with the rate-limiting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc2389100509e821a331ad70ab321fa
https://doi.org/10.1111/imm.13569
https://doi.org/10.1111/imm.13569
Autor:
Thuc M. Le, Hailey R. Lee, Evan R. Abt, Khalid Rashid, Amanda L. Creech, Keke Liang, Jing Cui, Arthur Cho, Liu Wei, Amanda Labora, Charlotte Chan, Eric Sanchez, Kriti Kriti, Daniel Karin, Luyi Li, Nanping Wu, Christine Mona, Giuseppe Carlucci, Willy Hugo, Ting-Ting Wu, Timothy R. Donahue, Johannes Czernin, Caius G. Radu
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol 64, iss 1
J Nucl Med
J Nucl Med
Stimulator of interferon genes (STING) is a mediator of immune recognition of cytosolic DNA, which plays important roles in cancer, cytotoxic therapies, and infections with certain pathogens. Although pharmacologic STING activation stimulates potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dfa01717ada663eac3090e4fe01b4a7
https://escholarship.org/uc/item/9w54v9cm
https://escholarship.org/uc/item/9w54v9cm
Autor:
Evan R. Abt, Thuc M. Le, Amanda M. Dann, Joseph R. Capri, Soumya Poddar, Vincent Lok, Luyi Li, Keke Liang, Amanda L. Creech, Khalid Rashid, Woosuk Kim, Nanping Wu, Jing Cui, Arthur Cho, Hailey Rose Lee, Ethan W. Rosser, Jason M. Link, Johannes Czernin, Ting-Ting Wu, Robert Damoiseaux, David W. Dawson, Timothy R. Donahue, Caius G. Radu
Publikováno v:
Cell reports, vol 38, iss 2
Cell Rep
Cell Rep
We determine that type I interferon (IFN) response biomarkers are enriched in a subset of pancreatic ductal adenocarcinoma (PDAC) tumors; however, actionable vulnerabilities associated with IFN signaling have not been systematically defined. Integrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184e71be22f63da9811bc2f5fbfa1b4e
https://escholarship.org/uc/item/62m2v7v7
https://escholarship.org/uc/item/62m2v7v7
Autor:
Keke, Liang, Evan R, Abt, Thuc M, Le, Arthur, Cho, Amanda M, Dann, Jing, Cui, Luyi, Li, Khalid, Rashid, Amanda L, Creech, Liu, Wei, Razmik, Ghukasyan, Ethan W, Rosser, Nanping, Wu, Giuseppe, Carlucci, Johannes, Czernin, Timothy R, Donahue, Caius G, Radu
Publikováno v:
Proc Natl Acad Sci U S A
Type I interferons (IFNs) are critical effectors of emerging cancer immunotherapies designed to activate pattern recognition receptors (PRRs). A challenge in the clinical translation of these agents is the lack of noninvasive pharmacodynamic biomarke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bda16d3ed8cff70ca44e2fd20f9d5230
https://pubmed.ncbi.nlm.nih.gov/34480004
https://pubmed.ncbi.nlm.nih.gov/34480004
Autor:
Evan R. Abt, Khalid Rashid, Thuc M. Le, Hailey R. Lee, Amanda L. Creech, Ting-Ting Wu, Thomas Mehrling, Shanta Bantia, Caius G. Radu
Publikováno v:
Cancer Research. 82:3034-3034
Purine nucleoside phosphorylase (PNP) functions as a central regulator of nucleotide metabolism by catalyzing the degradation of purine nucleosides guanosine and deoxyguanosine. PNP inactivation has been paradoxically associated with both immunodefic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3c0928e37d15537354a3461310a1950
https://doi.org/10.1158/1538-7445.am2022-3034
https://doi.org/10.1158/1538-7445.am2022-3034
Autor:
Hailey R. Lee, Evan R. Abt, Khalid Rashid, Amanda L. Creech, Keke Liang, Liu Wei, Arthur Cho, Willy Hugo, Timothy R. Donahue, Johannes Czernin, Caius G. Radu, Thuc M. Le
Publikováno v:
Cancer Research. 82:2483-2483
Stimulator of interferon genes (STING) coordinates innate and adaptive immune responses by mediating type I interferon and NF-κB signaling and is therefore a promising cancer immunotherapy target. While first generation STING agonists have advanced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::172ea1ee6b2cd7cf63fab2c6e12cc096
https://doi.org/10.1158/1538-7445.am2022-2483
https://doi.org/10.1158/1538-7445.am2022-2483