Výsledky vyhledávání - "Thuan B. Nguyen"

Controlling Plasma Protein Binding: Structural Correlates of Interactions of Hydrophobic Polyamine Endotoxin Sequestrants with Human Serum Albumin

Autor: Diptesh Sil, Hemamali J. Warshakoon, Thuan B. Nguyen, Sunil A. David, Stewart J. Wood, E. V. K. Suresh Kumar, Apurba Datta, Kelly A. Miller

Publikováno v: Molecular Pharmaceutics. 5:1131-1137

Hydrophobically substituted polyamine compounds, particularly N-acyl or N-alkyl derivatives of homospermine, are potent endotoxin (lipopolysaccharide) sequestrants. Despite their polycationic nature, the aqueous solubilites are limited owing to the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6ebce9244a2cde4fc91f63623b467a
https://doi.org/10.1021/mp8001123

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Protection from endotoxic shock by EVK-203, a novel alkylpolyamine sequestrant of lipopolysaccharide

Autor: Thuan B. Nguyen, E. V. K. Suresh Kumar, Rajalakshmi Balakrishna, Sunil A. David, Matthew R. Kimbrell, Apurba Datta, Kelly A. Miller, Ashok Kumar Adisechan

Publikováno v: Bioorganic & Medicinal Chemistry. 15:5694-5709

Lipopolysaccharides (LPS) play a key role in the pathogenesis of septic shock, a major cause of mortality in the critically ill patient. The only therapeutic option aimed at limiting downstream systemic inflammatory processes by targeting lipopolysac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a5bbe9498deba6aaa8b9f8010b1873
https://doi.org/10.1016/j.bmc.2007.06.015

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Bound To Shock: Protection from Lethal Endotoxemic Shock by a Novel, Nontoxic, Alkylpolyamine Lipopolysaccharide Sequestrant

Autor: Shravan Arora, Diptesh Sil, Apurba Datta, Matthew R. Kimbrell, Shannon Short, Sunil A. David, Jens R. Cromer, Anurupa Shrestha, Benjamin G. Abbo, Thuan B. Nguyen, Kelly A. Miller, Subbalakshmi S. Malladi, Ashok Kumar Adisechan, Rajalakshmi Balakrishna

Publikováno v: Antimicrobial Agents and Chemotherapy. 51:2811-2819

Lipopolysaccharide (LPS), or endotoxin, a structural component of gram-negative bacterial outer membranes, plays a key role in the pathogenesis of septic shock, a syndrome of severe systemic inflammation which leads to multiple-system organ failure.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65aeee5d3070b439764e6f63eff6ba0
https://doi.org/10.1128/aac.00200-07

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Does the use of particulate bone graft increase the incidence of postoperative infection in surgery for craniosynostosis?

Autor: Thuan B. Nguyen, Lynette Baker, Arshad R. Muzaffar, Abby Warren

Publikováno v: The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. 52(1)

Objective The use of particulate bone graft (PBG) has become an accepted technique for filling cranial defects created during cranial vault expansion for craniosynostosis. However, the use of PBG may be a risk factor for postoperative infection. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287773ae6b8634e51e86f9ea2016f533
https://pubmed.ncbi.nlm.nih.gov/24878347

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Polycationic sulfonamides for the sequestration of endotoxin

Autor: Rajalakshmi Balakrishna, Mark R. Burns, Sunil A. David, Benjamin G. Abbo, Scott Jenkins, Matthew R. Kimbrell, Thuan B. Nguyen

Publikováno v: Journal of medicinal chemistry. 50(4)

Lipopolysaccharides (LPS) play a key role in the pathogenesis of septic shock, a major cause of mortality in the critically ill patient. We had previously shown that monoacylated polyamine compounds specifically bind to and neutralize the activity of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d068d91cc41cb2b3e2890d0ac32aa128
https://pubmed.ncbi.nlm.nih.gov/17256835

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Structural Correlation Between Lipophilicity and Lipopolysaccharide-sequestering activity in Spermine-Sulfonamide Analogs

Autor: Nicolas M. Vermeulen, Scott Jenkins, Rajalakshmi Balakrishna, Matthew R. Kimbrell, Mark R. Burns, Thuan B. Nguyen, Sunil A. David

Lipopolysaccharides (LPS), otherwise termed 'endotoxins', are outer-membrane constituents of Gram-negative bacteria, and play a key role in the pathogenesis of 'Septic Shock', a major cause of mortality in the critically ill patient. We had previousl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff607f25a8e7009b90ab0931a421cbb
https://europepmc.org/articles/PMC1991285/

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Structural correlates of antibacterial and membrane-permeabilizing activities in acylpolyamines

Autor: Rajalakshmi Balakrishna, Stewart J. Wood, Kelly A. Miller, Apurba Datta, E. V. K. Suresh Kumar, Sunil A. David, Thuan B. Nguyen

Publikováno v: Antimicrobial agents and chemotherapy. 50(3)

A homologous series of mono- and bis-acyl polyamines with varying acyl chain lengths originally synthesized for the purpose of sequestering lipopolysaccharide were evaluated for antimicrobial activity to test the hypothesis that these bis-cationic am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6014a70f361e32794d99c2a36789bc6b
https://pubmed.ncbi.nlm.nih.gov/16495242

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Novel endotoxin-sequestering compounds with terephthalaldehyde-bis-guanylhydrazone scaffolds

Autor: Stewart J. Wood, Sunil A. David, Kriangsak Khownium, Thuan B. Nguyen, Matthew R. Kimbrell, Rajalakshmi Balakrishna, Kelly A. Miller, Gunda I. Georg

Publikováno v: Bioorganicmedicinal chemistry letters. 16(5)

We have shown that lipopolyamines bind to the lipid A moiety of lipopolysaccharide, a constituent of Gram-negative bacterial membranes, and neutralize its toxicity in animal models of endotoxic shock. In an effort to identify non-polyamine scaffolds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cccb17cb9bfa246325281809e6c9689
https://pubmed.ncbi.nlm.nih.gov/16377188

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Functionalized dendrimers as endotoxin sponges

Autor: Sunil A. David, Jens R. Cromer, Thuan B. Nguyen, Stewart J. Wood, Kelly A. Miller

Publikováno v: Bioorganicmedicinal chemistry letters. 15(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f818f3cda378f6beb53afb3419dba18c
https://pubmed.ncbi.nlm.nih.gov/15713373

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Incidence of Amblyopia and Its Risk Factors in Children With Isolated Metopic Craniosynostosis

Autor: Arshad R. Muzaffar, Leslie A. Shock, Thuan B. Nguyen, Tara G. Missoi

Publikováno v: The Cleft Palate-Craniofacial Journal. :141208072717004

Objective Ophthalmic abnormalities in children with syndromic craniosynostosis have been reported previously, and referral of these children to a pediatric ophthalmologist is recommended. However, it is not as clear whether a child with nonsyndromic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4786bb3fef864e3eefb5047f01079af4
https://doi.org/10.1597/14-212r

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