Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Thu-Thuy T. Dang"'
Autor:
Tuan-Anh M. Nguyen, Dagny Grzech, Khoa Chung, Zhicheng Xia, Trinh-Don Nguyen, Thu-Thuy T. Dang
Publikováno v:
Frontiers in Plant Science, Vol 14 (2023)
Spirooxindole alkaloids feature a unique scaffold of an oxindole ring sharing an atom with a heterocyclic moiety. These compounds display an extensive range of biological activities such as anticancer, antibiotics, and anti-hypertension. Despite thei
Externí odkaz:
https://doaj.org/article/0122f565b7344705acbec756a7913021
Autor:
Tuan-Anh M. Nguyen, Trinh-Don Nguyen, Yuen Yee Leung, Matthew McConnachie, Oleg Sannikov, Zhicheng Xia, Thu-Thuy T. Dang
Publikováno v:
Communications Chemistry, Vol 4, Iss 1, Pp 1-7 (2021)
Camptothecin derivatives are precursors of potent anticancer agents, but their biosynthesis remains largely unknown. Here two cytochrome P450 monooxygenases are shown to regiospecifically oxidize camptothecin, yielding 10- and 11- hydroxylated deriva
Externí odkaz:
https://doaj.org/article/a4636663e9554be2a14b9b29affc4904
Publikováno v:
ACS Omega, Vol 5, Iss 10, Pp 5565-5573 (2020)
Externí odkaz:
https://doaj.org/article/42475c3c10a8426098ca4afb70407a4f
Publikováno v:
Frontiers in Plant Science, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/e1b9c554e08b4e0d96d100f109fc60de
Autor:
Trinh-Don Nguyen, Thu-Thuy T. Dang
Publikováno v:
Frontiers in Plant Science, Vol 12 (2021)
Plants produce more than 20,000 nitrogen-containing heterocyclic metabolites called alkaloids. These chemicals serve numerous eco-physiological functions in the plants as well as medicines and psychedelic drugs for human for thousands of years, with
Externí odkaz:
https://doaj.org/article/f0cffb998dc2493fbabe3030b2bdbd65
Autor:
Carsten Schotte, Yindi Jiang, Dagny Grzech, Thu-Thuy T. Dang, Larissa C. Laforest, Francisco León, Marco Mottinelli, Satya Swathi Nadakuduti, Christopher R. McCurdy, Sarah E. O’Connor
Publikováno v:
Journal of the American Chemical Society
Mitragyna speciosa(“Kratom”) is used as a natural remedy for pain and management of opioid dependence. The pharmacological properties of Kratom have been linked to a complex mixture of monoterpene indole alkaloids, most notably mitragynine. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3d2974dfda1ffe4598f63db485a349
https://doi.org/10.1021/jacs.2c13644
https://doi.org/10.1021/jacs.2c13644
Autor:
Evangelos C. Tatsis, Inês Carqueijeiro, Thomas Dugé de Bernonville, Jakob Franke, Thu-Thuy T. Dang, Audrey Oudin, Arnaud Lanoue, Florent Lafontaine, Anna K. Stavrinides, Marc Clastre, Vincent Courdavault, Sarah E. O’Connor
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The biosynthetic pathway of preakuammicine, a monoterpene precursor of the anti-cancer agent vinblastine, has remained largely unexplored. Here, the authors provide transcriptomic and biochemical data to identify two enzymes that, in tandem, convert
Externí odkaz:
https://doaj.org/article/03bb68418f55480082f388e21cdaf80b
Autor:
Nguyen, Tuan-Anh M., Grzech, Dagny, Khoa Chung, Zhicheng Xia, Trinh-Don Nguyen, Thu-Thuy T. Dang
Publikováno v:
Frontiers in Plant Science; 2/3/2023, Vol. 14, p1-7, 7p
Publikováno v:
Science. 379:1187-1188
Reconstituting a plant biosynthetic pathway enables a sustainable supply of vaccine adjuvants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1bcf067f67681eb643acdfa0e3fe326
https://doi.org/10.1126/science.adg8823
https://doi.org/10.1126/science.adg8823
Publikováno v:
Current opinion in plant biology. 71
Major hurdles in plant biosynthetic pathway elucidation and engineering include the need for rapid testing of enzyme candidates and the lack of complex substrates that are often not accumulated in the plant, amenable to synthesis, or commercially ava
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633015157a4c78e790e968e8efacc4b9
https://pubmed.ncbi.nlm.nih.gov/36599248
https://pubmed.ncbi.nlm.nih.gov/36599248