Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Thrombomodulin alfa"'
Publikováno v:
Journal of Pharmaceutical Health Care and Sciences, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract Background Human soluble recombinant thrombomodulin (TM alfa), a treatment for septic Disseminated intravascular coagulation (DIC), is recommended for patients with severe renal dysfunction in reduced doses. However, no studies have examined
Externí odkaz:
https://doaj.org/article/df7d50bce8fb4d818c7b84d78c523341
Autor:
Tomoyoshi Miyamoto, Risa Domoto, Fumiko Sekiguchi, Riki Kamaguchi, Rika Nishimura, Misato Matsuno, Maho Tsubota, Masanori Fujitani, Shigekatsu Hatanaka, Yuichi Koizumi, Dengli Wang, Masahiro Nishibori, Atsufumi Kawabata
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 3, Pp 315-325 (2022)
Oxaliplatin often induces peripheral neuropathy, a dose-limiting adverse reaction, and in rare cases leads to sinusoidal obstruction syndrome. We thus conducted a retrospective cohort study to examine the relationship between oxaliplatin-induced peri
Externí odkaz:
https://doaj.org/article/ae80f6ce76474753aac680a6bbaefe92
Autor:
Fumiko Sekiguchi, Atsufumi Kawabata
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 367 (2020)
Chemotherapy-induced peripheral neuropathy (CIPN), one of major dose-limiting side effects of first-line chemotherapeutic agents such as paclitaxel, oxaliplatin, vincristine, and bortezomib is resistant to most of existing medicines. The molecular me
Externí odkaz:
https://doaj.org/article/8f9dc39cabc241b090ab8b061285162d
Akademický článek
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Autor:
Akio Hirayama, Naoki Aikawa, Shuji Shimazaki, Hidehiko Saito, Goichi Honda, Yasuhiro Yamamoto, Ikuro Maruyama, Takashi Ito
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 7, Pp 1141-1149 (2020)
Research and Practice in Thrombosis and Haemostasis
Research and Practice in Thrombosis and Haemostasis
Background The efficacy and safety of thrombomodulin alfa (TM-α), a cofactor protein promoting thrombin-mediated protein C activation, have been examined in a phase 3 randomized, double-blinded, parallel-group trial in Japan. We have previously repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ac7e791ac8604dcf8a8df0b20b66bc
https://doaj.org/article/d5ebd439b6bc4e76827a7b06f5e957e1
https://doaj.org/article/d5ebd439b6bc4e76827a7b06f5e957e1
Autor:
Tetsuji Kawamura, Sakae Homma, Hiroyuki Taniguchi, Arata Azuma, Yoshikazu Inoue, Noriho Sakamoto, Kiminori Fujimoto, Masaki Okamoto, Natsuki Yamamori, Masahito Ebina, Jun Araya, Yoshio Taguchi, Shinji Abe, Yoshihito Yamada, Mitsuhiro Abe, Yasuhiro Kondoh, Kenji Tsushima, Machiko Arita, Hiroyoshi Yamauchi, Joe Shindoh, Susumu Sakamoto, Shinyu Izumi, Jun Tagawa, Yasuo Matsuzawa, Hiroshi Ishii, Masahiro Aoshima, Takafumi Suda, Naozumi Hashimoto, Takeshi Johkoh, Yuji Tohda, Kazuma Kishi, Koji Bessho, Takashi Ogura, Keisuke Tomii, Takefumi Saito, Kazuya Ichikado
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 201:1110-1119
Rationale: Acute exacerbation during the course of idiopathic pulmonary fibrosis causes a poor prognosis. Coagulation abnormalities and endothelial damage are involved in its pathogenesis. Thrombom...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab20e4ca6c6730f4ea7af8c0438e57c9
https://doi.org/10.1164/rccm.201909-1818oc
https://doi.org/10.1164/rccm.201909-1818oc
Autor:
Tomoyoshi Miyamoto, Risa Domoto, Fumiko Sekiguchi, Riki Kamaguchi, Rika Nishimura, Misato Matsuno, Maho Tsubota, Masanori Fujitani, Shigekatsu Hatanaka, Yuichi Koizumi, Dengli Wang, Masahiro Nishibori, Atsufumi Kawabata
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 3, Pp 315-325 (2022)
Oxaliplatin often induces peripheral neuropathy, a dose-limiting adverse reaction, and in rare cases leads to sinusoidal obstruction syndrome. We thus conducted a retrospective cohort study to examine the relationship between oxaliplatin-induced peri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b278129c51190f7e8fcf3e8a18beaf6d
https://pubmed.ncbi.nlm.nih.gov/35177211
https://pubmed.ncbi.nlm.nih.gov/35177211
Autor:
Fumihiko Katagiri, Saori Hatoyama-Tanaka, Satoshi Nagase, Risa Takayanagi, Hiroyuki Takahashi, Hiroshi Kanno, Miki Tsumori, Masaharu Imaura, Kazuya Omura, Yasuhiko Yamada
Publikováno v:
Shock. 54:50-55
In the treatment of disseminated intravascular coagulation (DIC), which is a complication of underlying diseases such as infections and malignant tumors, effective plasma concentrations of thrombomodulin (TM) alfa range from 300 to 900 ng/mL; however
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa6d2d47164b550bcf84c0ec2587715
https://doi.org/10.1097/shk.0000000000001477
https://doi.org/10.1097/shk.0000000000001477
Akademický článek
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Effect of Thrombomodulin Alfa on Disseminated Intravascular Coagulation in Patients with Lung Cancer
Autor:
Hideyuki Satoh, Shingo Tokita, Kenya Koyama, Hiroyoshi Watanabe, Masamitsu Tatewaki, Kumiya Sugiyama, Ryosuke Souma, Tomoshige Wakayama, Hirokuni Hirata, Kentaro Nakano, Hiroyuki Masuda, Yasutsugu Fukushima, Naruo Yoshida, Takayoshi Fujimatsu, Hajime Arifuku
Publikováno v:
Internal Medicine
Objective The mortality rate due to disseminated intravascular coagulation (DIC) is higher in patients with lung cancer than in those without. We examined the effect of treatment with thrombomodulin alfa (TM-α) for DIC in lung cancer patients. Metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a845acfac9a6a6fc739890feb524ccb3
https://doi.org/10.2169/internalmedicine.56.7143
https://doi.org/10.2169/internalmedicine.56.7143