Výsledky vyhledávání - "Thrombomodulin/biosynthesis/genetics"

Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells

Autor: Maejima, T., Inoue, T., Kanki, Y., Kohro, T., Li, G., Ohta, Y., Kimura, Hiroshi, Kobayashi, M., Taguchi, A., Tsutsumi, S., Iwanari, H., Yamamoto, S., Aruga, H., Dong, S., Stevens, J. F., Poh, H. M., Yamamoto, K., Kawamura, T., Mimura, I., Suehiro, J., Sugiyama, A., Kaneki, K., Shibata, H., Yoshinaka, Y., Doi, T., Asanuma, A., Tanabe, S., Tanaka, T., Minami, T., Hamakubo, T., Sakai, J., Nozaki, N., Aburatani, H., Nangaku, M., Ruan, X., Tanabe, H., Ruan, Y., Ihara, S., Endo, A., Kodama, T., Wada, Y.

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 5, p e96005 (2014)

Statins exert atheroprotective effects through the induction of specific transcriptional factors in multiple organs. In endothelial cells, statin-dependent atheroprotective gene up-regulation is mediated by Kruppel-like factor (KLF) family transcript

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