A functional siRNA screen identifies RhoGTPase-associated genes involved in thrombin-induced endothelial permeability

Autor: Renee X. de Menezes, Peter L. Hordijk, Victor W.M. van Hinsbergh, Geerten P. van Nieuw Amerongen, Joana Amado-Azevedo

Publikováno v: PLoS ONE, Vol 13, Iss 7, p e0201231 (2018)
Amado-Azevedo, J, de Menezes, R X, van Nieuw Amerongen, G P, van Hinsbergh, V W M & Hordijk, P L 2018, ' A functional siRNA screen identifies RhoGTPase-associated genes involved in thrombin-induced endothelial permeability ', PLoS ONE, vol. 13, no. 7, e0201231 . https://doi.org/10.1371/journal.pone.0201231
PLoS ONE, 13(7):e0201231. Public Library of Science
PLoS ONE

Thrombin and other inflammatory mediators may induce vascular permeability through the disruption of adherens junctions between adjacent endothelial cells. If uncontrolled, hyperpermeability leads to an impaired barrier, fluid leakage and edema, whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a667952db6372d5200009f71d531ad4a
http://europepmc.org/articles/PMC6062096?pdf=render

Effects of cognate, non-cognate and synthetic CXCR4 and ACKR3 ligands on human lung endothelial cell barrier function

Autor: Matthias Majetschak, Heather M. LaPorte, Brian F. Volkman, Jonathan M. Eby, You-Hong Cheng

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0187949 (2017)
PLoS ONE

Recent evidence suggests that chemokine CXCL12, the cognate agonist of chemokine receptors CXCR4 and ACKR3, reduces thrombin-mediated impairment of endothelial barrier function. A detailed characterization of the effects of CXCL12 on thrombin-mediate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efcf5d5df64178929d97c3cb867abbbc
http://europepmc.org/articles/PMC5681266?pdf=render

Surgery increases cell death and induces changes in gene expression compared with anesthesia alone in the developing piglet brain

Autor: Broad, Kevin D, Kawano, Go, Fierens, Igor, Rocha-Ferreira, Eridan, Hristova, Mariya, Ezzati, Mojgan, Rostami, Jamshid, Alonso-Alconada, Daniel, Chaban, Badr, Hassell, Jane, Fleiss, Bobbi, Gressens, Pierre, Sanders, Robert D, Robertson, Nicola J

Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0173413 (2017)
PLoS ONE
Broad, K D, Kawano, G, Fierens, I, Rocha-Ferreira, E, Hristova, M, Ezzati, M, Rostami, J, Alonso-Alconada, D, Chaban, B, Hassell, J, Fleiss, B, Gressens, P, Sanders, R D & Robertson, N J 2017, ' Surgery increases cell death and induces changes in gene expression compared with anesthesia alone in the developing piglet brain ', PLoS ONE, vol. 12, no. 3, e0173413 . https://doi.org/10.1371/journal.pone.0173413

In a range of animal species, exposure of the brain to general anaesthesia without surgery during early infancy may adversely affect its neural and cognitive development. The mechanisms mediating this are complex but include an increase in brain cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::eb143f0d9bdd85434a5d0017cb9ac3e1
http://europepmc.org/articles/PMC5371291?pdf=render

Meso scale discovery-based assays for the detection of aggregated huntingtin

Autor: Frank Herrmann, Douglas Macdonald, Gillian P. Bates, Jonathan Bard, Ilka Lindner, Isabell Cardaun, Andreas Weiss, Ignacio Munoz-Sanjuan, Tom Schwagarus, Christina Schmidt, Markus Kleinschmidt, Wolfgang Reindl, Georgina F. Osborne, Celina Zerbinatti, Isabell Janack, Karsten Tillack, Christina Thiede, Madlen Hotze, Simone Herrmann, Jana Schulz, Yalda Sedaghat, Barbara Baldo

Publikováno v: PLoS ONE, Vol 14, Iss 3, p e0213521 (2019)
PLoS ONE

Huntington's disease (HD) is a monogenic neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat domain in the huntingtin (HTT) gene, leading to an expanded poly-glutamine (polyQ) stretch in the HTT protein. This mutant HTT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f582ecd28e04d6c5042cdd6e27fa77
https://doi.org/10.1371/journal.pone.0213521

Phosphoproteomic analysis of platelets activated by pro-thrombotic oxidized phospholipids and thrombin

Autor: Sudipta Biswas, Evangelia Komisopoulou, Thomas G. Graeber, Eugene A. Podrez, Alejandro Zimman, Bjoern Titz

Publikováno v: PloS one, vol 9, iss 1
PLoS ONE
PLoS ONE, Vol 9, Iss 1, p e84488 (2014)

Specific oxidized phospholipids (oxPCCD36) promote platelet hyper-reactivity and thrombosis in hyperlipidemia via the scavenger receptor CD36, however the signaling pathway(s) induced in platelets by oxPCCD36 are not well defined. We have employed ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c42b00d4bdd2dbf1858cb92d4a8200c2
https://escholarship.org/uc/item/4kd7m3nq