Výsledky vyhledávání - "Thrombin/pharmacology"

Caveolin-1 opens endothelial cell junctions by targeting catenins

Autor: Romy Kronstein, Hans-Joachim Schnittler, Carsten Minten, Abdallah Abu Taha, Yvan Arsenijevic, Tatiana Afanasieva, Marek Drab, Jochen Seebach, Stefan Liebner, Sylvia Grossklaus, Britta Engelhardt

Publikováno v: Cardiovascular Research, vol. 93, no. 1, pp. 130-140
Kronstein, Romy; Seebach, Jochen; Grossklaus, Sylvia; Minten, Carsten; Engelhardt, Britta; Drab, Marek; Liebner, Stefan; Arsenijevic, Yvan; Taha, Abdallah Abu; Afanasieva, Tatiana; Schnittler, Hans-Joachim (2012). Caveolin-1 opens endothelial cell junctions by targeting catenins. Cardiovascular research, 93(1), pp. 130-40. Oxford: Oxford University Press 10.1093/cvr/cvr256

AIMS: A fundamental phenomenon in inflammation is the loss of endothelial barrier function, in which the opening of endothelial cell junctions plays a central role. However, the molecular mechanisms that ultimately open the cell junctions are largely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5659795732fad4950547b7c085aac6be
https://serval.unil.ch/notice/serval:BIB_CCF339084AD6

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Both ADP and thrombin regulate arteriolar thrombus stabilization and embolization, but are not involved in initial hemostasis as induced by micropuncture

Autor: Dick W. Slaaf, Robert S. Reneman, Margareta Elg, Sietze Reitsma, Theo Lindhout, Marion A.H. Feijge, Mirjam G.A. oude Egbrink, Miriam A. van Gestel, Viviane V.Th. Heijnen, Marc A. M. J. van Zandvoort, Johan W. M. Heemskerk

Publikováno v: Microcirculation (New York, N.Y., 14(3), 193-205. Wiley-Blackwell

OBJECTIVE: Thrombosis and embolization are main causes of morbidity and mortality. Up to now, the relative importance of mediators involved is only partly known. It was the aim of this study to investigate the involvement of ADP and thrombin in subse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81bab234db924135c25c257ccf69c1e
https://pubmed.ncbi.nlm.nih.gov/17454672

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Endothelial, but not smooth muscle, peroxisome proliferator-activated receptor β/δ regulates vascular permeability and anaphylaxis

Autor: Marta Wawrzyniak, David Dombrowicz, Hélène Mottaz, Frédéric Schütz, Christine Pich, Liliane Michalik, Emmanuel Bouchaert, Catherine Moret, Corinne Rommens, Barbara Gross, Lionel Mury, Sébastien Fleury, Sandrine Quemener, Marie Sgandurra

Publikováno v: Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, Elsevier, 2015, 135 (6), pp.1625-1635e5. ⟨10.1016/j.jaci.2014.11.006⟩
Journal of Allergy and Clinical Immunology, 2015, 135 (6), pp.1625-1635e5. ⟨10.1016/j.jaci.2014.11.006⟩

Background Remodeling of quiescent vessels with increases in permeability, vasodilatation, and edema are hallmarks of inflammatory disorders. Factors involved in this type of remodeling represent potential therapeutic targets. Objectives We investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe21e7ceff6cde430460011a71b8b64a
https://doi.org/10.1016/j.jaci.2014.11.006

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Cdc42 regulates the restoration of endothelial barrier function

Autor: Panos Kouklis, Maria Konstantoulaki, Asrar B. Malik, Stephen M. Vogel, Michael Broman

Publikováno v: Circulation research. 94(2)

The mechanisms involved in the restoration of endothelial cell junctions subsequent to barrier disruption remain unclear. It is known that formation of adherens junctions (AJs) affects cytoskeletal actin arrangement and that Rho GTPases regulate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74fec740140c0507a458a34a0ac9752
https://pubmed.ncbi.nlm.nih.gov/14656933

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Protein kinase C modifications of VE-cadherin, p120, and beta-catenin contribute to endothelial barrier dysregulation induced by thrombin

Autor: Konstantoulaki, M., Kouklis, P., Malik, A. B.

The adherens junction is a multiprotein complex consisting of the transmembrane vascular endothelial cadherin (VEC) and cytoplasmic catenins (p120, beta-catenin, plakoglobin, alpha-catenin) responsible for the maintenance of endothelial barrier funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::498b8fbdffe070962151a3c0ffa76750
http://olympias.lib.uoi.gr/jspui/handle/123456789/18955

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Ca(2+) signalling and PKCalpha activate increased endothelial permeability by disassembly of VE-cadherin junctions

Autor: Sandoval, R., Malik, A. B., Minshall, R. D., Kouklis, P., Ellis, C. A., Tiruppathi, C.

1. The role of intracellular Ca(2+) mobilization in the mechanism of increased endothelial permeability was studied. Human umbilical vein endothelial cells (HUVECs) were exposed to thapsigargin or thrombin at concentrations that resulted in similar i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::0472cb810ece41cc90f4f5089f56b3ca
http://olympias.lib.uoi.gr/jspui/handle/123456789/23360

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Thrombin regulates tissue factor and thrombomodulin mRNA levels and activities in human saphenous vein endothelial cells by distinct mechanisms

Autor: K. Bartha, C. Brisson, G. Archipoff, C. de la Salle, F. Lanza, J.P. Cazenave, A. Beretz

Publikováno v: The Journal of biological chemistry
The Journal of biological chemistry, 1993, 268 (1), pp.421-429
Alain Beretz
Scopus-Elsevier
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1993, 268 (1), pp.421-429
Europe PubMed Central

The effects of thrombin, D-phenylalanyl-L-propyl-L-arginine chloromethyl ketone (PPACK)-inhibited thrombin, and thrombin receptor agonist peptide, SFLLRNPNDKYEPF (SFLL, a portion of the receptor unmasked after thrombin cleavage), on the expression of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff050c2438da0e99a26b3f6e0da43360
https://pubmed.ncbi.nlm.nih.gov/7678000

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Autocrine regulation of endothelial exocytosis: von Willebrand factor release is induced by prostacyclin in cultured endothelial cells

Autor: Ulrich M. Vischer, Claes B. Wollheim, U. Lang

Publikováno v: FEBS Letters, Vol. 424, No 3 (1998) pp. 211-5

Vascular endothelial cells respond to external stimuli by altering the secretion of several bioactive molecules, including von Willebrand factor (vWf), prostacyclin (PGI2) and nitric oxide (NO). The release of all three molecules is regulated by a ri

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