Fit-for-purpose heterodivalent single-domain antibody for gastrointestinal targeting of toxin B from Clostridium difficile.

Autor: Rodriguez Rodriguez ER; Bactolife A/S, Copenhagen East, Denmark., Nordvang RT; Bactolife A/S, Copenhagen East, Denmark., Petersson M; Bactolife A/S, Copenhagen East, Denmark.; Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark., Rendsvig JKH; Bactolife A/S, Copenhagen East, Denmark., Arendrup EW; Bactolife A/S, Copenhagen East, Denmark., Fernández Quintero ML; Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark., Jenkins TP; Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark., Laustsen AH; Bactolife A/S, Copenhagen East, Denmark.; Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark., Thrane SW; Bactolife A/S, Copenhagen East, Denmark.

Publikováno v: Protein science : a publication of the Protein Society [Protein Sci] 2024 Jul; Vol. 33 (7), pp. e5035.

Orally delivered single-domain antibodies against gastrointestinal pathogens.

Autor: Petersson M; Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark; Bactolife A/S, Copenhagen East, Denmark., Thrane SW; Bactolife A/S, Copenhagen East, Denmark., Gram L; Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark., Muyldermans S; Department of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium., Laustsen AH; Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark; Bactolife A/S, Copenhagen East, Denmark. Electronic address: ahola@bio.dtu.dk.

Publikováno v: Trends in biotechnology [Trends Biotechnol] 2023 Jul; Vol. 41 (7), pp. 875-886. Date of Electronic Publication: 2023 Feb 09.

Hepatic transcriptome signatures in patients with varying degrees of nonalcoholic fatty liver disease compared with healthy normal-weight individuals.

Autor: Suppli MP; Department of Clinical Metabolic Physiology, Steno Diabetes Center Copenhagen, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark., Rigbolt KTG; Gubra, Hørsholm , Denmark., Veidal SS; Gubra, Hørsholm , Denmark., Heebøll S; Department of Hepatology and Gastroenterology, Aarhus University Hospital , Aarhus , Denmark., Eriksen PL; Department of Hepatology and Gastroenterology, Aarhus University Hospital , Aarhus , Denmark., Demant M; Department of Clinical Metabolic Physiology, Steno Diabetes Center Copenhagen, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark., Bagger JI; Department of Clinical Metabolic Physiology, Steno Diabetes Center Copenhagen, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark., Nielsen JC; Gubra, Hørsholm , Denmark., Oró D; Gubra, Hørsholm , Denmark., Thrane SW; Gubra, Hørsholm , Denmark., Lund A; Department of Clinical Metabolic Physiology, Steno Diabetes Center Copenhagen, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark., Strandberg C; Department of Radiology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark., Kønig MJ; Department of Radiology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark., Vilsbøll T; Department of Clinical Metabolic Physiology, Steno Diabetes Center Copenhagen, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark., Vrang N; Gubra, Hørsholm , Denmark., Thomsen KL; Department of Hepatology and Gastroenterology, Aarhus University Hospital , Aarhus , Denmark., Grønbæk H; Department of Hepatology and Gastroenterology, Aarhus University Hospital , Aarhus , Denmark., Jelsing J; Gubra, Hørsholm , Denmark., Hansen HH; Gubra, Hørsholm , Denmark., Knop FK; Department of Clinical Metabolic Physiology, Steno Diabetes Center Copenhagen, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark.

Publikováno v: American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2019 Apr 01; Vol. 316 (4), pp. G462-G472. Date of Electronic Publication: 2019 Jan 17.

A Bacteriophage-Acquired O-Antigen Polymerase (Wzyβ) from P. aeruginosa Serotype O16 Performs a Varied Mechanism Compared to Its Cognate Wzyα.

Autor: Taylor VL; Department of Molecular and Cellular Biology, University of Guelph Guelph, ON, Canada., Hoage JF; Department of Molecular and Cellular Biology, University of Guelph Guelph, ON, Canada., Thrane SW; Department of Systems Biology, Technical University of Denmark Kongens Lyngby, Denmark., Huszczynski SM; Department of Molecular and Cellular Biology, University of Guelph Guelph, ON, Canada., Jelsbak L; Department of Systems Biology, Technical University of Denmark Kongens Lyngby, Denmark., Lam JS; Department of Molecular and Cellular Biology, University of Guelph Guelph, ON, Canada.

Publikováno v: Frontiers in microbiology [Front Microbiol] 2016 Mar 31; Vol. 7, pp. 393. Date of Electronic Publication: 2016 Mar 31 (Print Publication: 2016).

Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium.

Autor: Freschi L; Institute for Integrative and Systems Biology, Université Laval Quebec, QC, Canada., Jeukens J; Institute for Integrative and Systems Biology, Université Laval Quebec, QC, Canada., Kukavica-Ibrulj I; Institute for Integrative and Systems Biology, Université Laval Quebec, QC, Canada., Boyle B; Institute for Integrative and Systems Biology, Université Laval Quebec, QC, Canada., Dupont MJ; Institute for Integrative and Systems Biology, Université Laval Quebec, QC, Canada., Laroche J; Institute for Integrative and Systems Biology, Université Laval Quebec, QC, Canada., Larose S; Institute for Integrative and Systems Biology, Université Laval Quebec, QC, Canada., Maaroufi H; Institute for Integrative and Systems Biology, Université Laval Quebec, QC, Canada., Fothergill JL; Institute of Infection and Global Health, University of Liverpool Liverpool, UK., Moore M; Institute of Infection and Global Health, University of Liverpool Liverpool, UK., Winsor GL; Department of Molecular Biology and Biochemistry, Simon Fraser University Vancouver, BC, Canada., Aaron SD; Ottawa Hospital Research Institute Ottawa, ON, Canada., Barbeau J; Faculté de Médecine Dentaire, Université de Montréal Montréal, QC, Canada., Bell SC; QIMR Berghofer Medical Research Institute Brisbane, QLD, Australia., Burns JL; Seattle Children's Research Institute, University of Washington School of Medicine Seattle, WA, USA., Camara M; School of Life Sciences, University of Nottingham Nottingham, UK., Cantin A; Département de Médecine, Université de Sherbrooke Sherbrooke, QC, Canada., Charette SJ; Institute for Integrative and Systems Biology, Université Laval Quebec, QC, Canada ; Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec Quebec, QC, Canada ; Département de Biochimie, de Microbiologie et de Bio-informatique, Faculté des Sciences et de Génie, Université Laval Quebec, QC, Canada., Dewar K; Department of Human Genetics, McGill University Montreal, QC, Canada., Déziel É; INRS Institut Armand Frappier Laval, QC, Canada., Grimwood K; School of Medicine, Griffith University Gold Coast, QLD, Australia., Hancock RE; Department of Microbiology and Immunology, University of British Columbia Vancouver, BC, Canada., Harrison JJ; Biological Sciences, University of Calgary Calgary, AB, Canada., Heeb S; School of Life Sciences, University of Nottingham Nottingham, UK., Jelsbak L; Department of Systems Biology, Technical University of Denmark Lyngby, Denmark., Jia B; M.G. DeGroote Institute for Infectious Disease Research, McMaster University Hamilton, ON, Canada., Kenna DT; Antimicrobial Resistance and Healthcare Associated Infections Reference Unit, Public Health England London, UK., Kidd TJ; Child Health Research Centre, The University of Queensland Brisbane, QLD, Australia ; Centre for Infection and Immunity, Queen's University Belfast Belfast, UK., Klockgether J; Klinische Forschergruppe, Medizinische Hochschule Hannover, Germany., Lam JS; Department of Molecular and Cellular Biology, University of Guelph Guelph, ON, Canada., Lamont IL; Department of Biochemistry, University of Otago Dunedin, New Zealand., Lewenza S; Biological Sciences, University of Calgary Calgary, AB, Canada., Loman N; Institute for Microbiology and Infection, University of Birmingham Birmingham, UK., Malouin F; Département de Médecine, Université de Sherbrooke Sherbrooke, QC, Canada., Manos J; Department of Infectious Diseases and Immunology, The University of Sydney Sydney, NSW, Australia., McArthur AG; M.G. DeGroote Institute for Infectious Disease Research, McMaster University Hamilton, ON, Canada., McKeown J; School of Life Sciences, University of Nottingham Nottingham, UK., Milot J; Department of Pneumology, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval Quebec, QC, Canada., Naghra H; School of Life Sciences, University of Nottingham Nottingham, UK., Nguyen D; Department of Human Genetics, McGill University Montreal, QC, Canada ; Department of Microbiology and Immunology and Department of Experimental Medicine, McGill University Montreal, QC, Canada., Pereira SK; M.G. DeGroote Institute for Infectious Disease Research, McMaster University Hamilton, ON, Canada., Perron GG; Department of Biology, Bard College, Annandale-On-Hudson NY, USA., Pirnay JP; Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital Brussels, Belgium., Rainey PB; New Zealand Institute for Advanced Study, Massey University Albany, New Zealand ; Max Planck Institute for Evolutionary Biology Plön, Germany., Rousseau S; Department of Human Genetics, McGill University Montreal, QC, Canada., Santos PM; Department of Biology, University of Minho Braga, Portugal., Stephenson A; St. Michael's Hospital Toronto, ON, Canada., Taylor V; Department of Molecular and Cellular Biology, University of Guelph Guelph, ON, Canada., Turton JF; Antimicrobial Resistance and Healthcare Associated Infections Reference Unit, Public Health England London, UK., Waglechner N; M.G. DeGroote Institute for Infectious Disease Research, McMaster University Hamilton, ON, Canada., Williams P; School of Life Sciences, University of Nottingham Nottingham, UK., Thrane SW; Department of Systems Biology, Technical University of Denmark Lyngby, Denmark., Wright GD; M.G. DeGroote Institute for Infectious Disease Research, McMaster University Hamilton, ON, Canada., Brinkman FS; Department of Molecular Biology and Biochemistry, Simon Fraser University Vancouver, BC, Canada., Tucker NP; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde Glasgow, UK., Tümmler B; Klinische Forschergruppe, Medizinische Hochschule Hannover, Germany., Winstanley C; Institute of Infection and Global Health, University of Liverpool Liverpool, UK., Levesque RC; Institute for Integrative and Systems Biology, Université Laval Quebec, QC, Canada.

Publikováno v: Frontiers in microbiology [Front Microbiol] 2015 Sep 29; Vol. 6, pp. 1036. Date of Electronic Publication: 2015 Sep 29 (Print Publication: 2015).