Emerging therapies for the treatment of rare pediatric bone disorders.

Autor: Thrailkill KM; Department of Pediatrics, University of Kentucky Barnstable Brown Diabetes Center, University of Kentucky College of Medicine, Lexington, KY, United States., Kalaitzoglou E; Department of Pediatrics, University of Kentucky Barnstable Brown Diabetes Center, University of Kentucky College of Medicine, Lexington, KY, United States., Fowlkes JL; Department of Pediatrics, University of Kentucky Barnstable Brown Diabetes Center, University of Kentucky College of Medicine, Lexington, KY, United States.

Publikováno v: Frontiers in pediatrics [Front Pediatr] 2022 Oct 11; Vol. 10, pp. 1012816. Date of Electronic Publication: 2022 Oct 11 (Print Publication: 2022).

Impact of an SGLT2-loss of function mutation on renal architecture, histology, and glucose homeostasis.

Autor: Hughes CB; Barnstable Brown Diabetes Center, University of Kentucky College of Medicine, 900 S. Limestone, CTW469, Lexington, KY, 40536, USA., Mussman GM; Barnstable Brown Diabetes Center, University of Kentucky College of Medicine, 900 S. Limestone, CTW469, Lexington, KY, 40536, USA., Ray P; Barnstable Brown Diabetes Center, University of Kentucky College of Medicine, 900 S. Limestone, CTW469, Lexington, KY, 40536, USA.; Department of Pediatric Endocrinology, University of Kentucky College of Medicine, 2195 Harrodsburg Rd, Lexington, KY, 40504, USA., Bunn RC; Barnstable Brown Diabetes Center, University of Kentucky College of Medicine, 900 S. Limestone, CTW469, Lexington, KY, 40536, USA.; Department of Pediatric Endocrinology, University of Kentucky College of Medicine, 2195 Harrodsburg Rd, Lexington, KY, 40504, USA., Cornea V; Department of Pathology, University of Kentucky Medical Center, 800 Rose Street, MS117, Lexington, KY, 40536, USA., Thrailkill KM; Barnstable Brown Diabetes Center, University of Kentucky College of Medicine, 900 S. Limestone, CTW469, Lexington, KY, 40536, USA.; Department of Pediatric Endocrinology, University of Kentucky College of Medicine, 2195 Harrodsburg Rd, Lexington, KY, 40504, USA., Fowlkes JL; Barnstable Brown Diabetes Center, University of Kentucky College of Medicine, 900 S. Limestone, CTW469, Lexington, KY, 40536, USA.; Department of Pediatric Endocrinology, University of Kentucky College of Medicine, 2195 Harrodsburg Rd, Lexington, KY, 40504, USA., Popescu I; Barnstable Brown Diabetes Center, University of Kentucky College of Medicine, 900 S. Limestone, CTW469, Lexington, KY, 40536, USA. iuliana.popescu@uky.edu.

Publikováno v: Cell and tissue research [Cell Tissue Res] 2021 May; Vol. 384 (2), pp. 527-543. Date of Electronic Publication: 2021 Jan 06.

A Randomized Controlled Trial on the Effect of Luseogliflozin on Bone Microarchitecture Evaluated Using HR-pQCT in Elderly Type 2 Diabetes.

Autor: Shigeno, Riyoko¹ (AUTHOR), Horie, Ichiro¹ (AUTHOR) horie@nagasaki-u.ac.jp, Haraguchi, Ai¹ (AUTHOR), Niimi, Ryuji² (AUTHOR), Chiba, Ko² (AUTHOR), Tashiro, Shigeki³ (AUTHOR), Kawazoe, Yurika³ (AUTHOR), Sato, Shuntaro³ (AUTHOR), Osaki, Makoto² (AUTHOR), Kawakami, Atsushi¹ (AUTHOR), Abiru, Norio¹ (AUTHOR)

Publikováno v: Diabetes Therapy. Oct2024, Vol. 15 Issue 10, p2233-2248. 16p.

Postnatal loss of the insulin receptor in osteoprogenitor cells does not impart a metabolic phenotype.

Autor: Fowlkes JL; University of Kentucky, Barnstable Brown Diabetes Center, Lexington, KY, USA. fowlkesjohnl@uky.edu.; Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY, 40536, USA. fowlkesjohnl@uky.edu., Clay Bunn R; University of Kentucky, Barnstable Brown Diabetes Center, Lexington, KY, USA.; Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY, 40536, USA., Kalaitzoglou E; University of Kentucky, Barnstable Brown Diabetes Center, Lexington, KY, USA.; Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY, 40536, USA., Ray P; University of Kentucky, Barnstable Brown Diabetes Center, Lexington, KY, USA., Popescu I; University of Kentucky, Barnstable Brown Diabetes Center, Lexington, KY, USA., Thrailkill KM; University of Kentucky, Barnstable Brown Diabetes Center, Lexington, KY, USA.; Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.

Publikováno v: Scientific reports [Sci Rep] 2020 Jun 01; Vol. 10 (1), pp. 8842. Date of Electronic Publication: 2020 Jun 01.

Constitutive activation of MEK1 in osteoprogenitors increases strength of bone despite impairing mineralization.

Autor: Fowlkes JL; University of Kentucky Barnstable Brown Diabetes Center, Lexington, KY, 40536, United States; Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY, 40536, United States. Electronic address: fowlkesjohnl@uky.edu., Bunn RC; University of Kentucky Barnstable Brown Diabetes Center, Lexington, KY, 40536, United States; Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY, 40536, United States., Ray PD; University of Kentucky Barnstable Brown Diabetes Center, Lexington, KY, 40536, United States; Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY, 40536, United States., Kalaitzoglou E; University of Kentucky Barnstable Brown Diabetes Center, Lexington, KY, 40536, United States; Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY, 40536, United States., Uppuganti S; Department of Orthopaedic Surgery and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, 37232, United States; Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, United States., Unal M; Department of Orthopaedic Surgery and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, 37232, United States; Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, United States., Nyman JS; Department of Orthopaedic Surgery and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, 37232, United States; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37232, United States; Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, United States; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, 37212, United States., Thrailkill KM; University of Kentucky Barnstable Brown Diabetes Center, Lexington, KY, 40536, United States; Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY, 40536, United States.

Publikováno v: Bone [Bone] 2020 Jan; Vol. 130, pp. 115106. Date of Electronic Publication: 2019 Nov 02.