Microglial TNFR2 signaling regulates the inflammatory response after CNS injury in a sex-specific fashion

Autor: Raffaele, Stefano, Thougaard, Estrid, Laursen, Cathrine C.H., Gao, Han, Andersen, Katrine M., Nielsen, Pernille V., Ortí-Casañ, Natalia, Blichfeldt-Eckhardt, Morten, Koch, Simon, Deb-Chatterji, Milani, Magnus, Tim, Stubbe, Jane, Madsen, Kirsten, Meyer, Morten, Degn, Matilda, Eisel, Ulrich L.M., Wlodarczyk, Agnieszka, Fumagalli, Marta, Clausen, Bettina H., Brambilla, Roberta, Lambertsen, Kate L.

Publikováno v: In Brain Behavior and Immunity February 2024 116:269-285

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TNFR2 signaling in oligodendrocyte precursor cells suppresses their immune-inflammatory function and detrimental microglia activation in CNS demyelinating disease.

Autor: Desu HL; The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Thougaard E; The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, 5230 Odense M, Denmark., Carney BN; The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Illiano P; The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Plastini MJ; The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Florimon Y; The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Mini A; The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Guastucci C; The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Kang B; The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Lee JK; The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Lambertsen KL; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, 5230 Odense M, Denmark; BRIDGE-Brain Research Inter Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, 5230 Odense M, Denmark; Department of Neurology, Odense University Hospital, 5000 Odense C, Denmark., Brambilla R; The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, 5230 Odense M, Denmark; BRIDGE-Brain Research Inter Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, 5230 Odense M, Denmark. Electronic address: rbrambilla@med.miami.edu.

Publikováno v: Brain, behavior, and immunity [Brain Behav Immun] 2024 Sep 05; Vol. 123, pp. 81-98. Date of Electronic Publication: 2024 Sep 05.