Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors

Autor: Laura Tornatore, Annamaria Sandomenico, Domenico Raimondo, Caroline Low, Alberto Rocci, Cathy Tralau-Stewart, Daria Capece, Daniel D’Andrea, Marco Bua, Eileen Boyle, Mark van Duin, Pietro Zoppoli, Albert Jaxa-Chamiec, Anil K. Thotakura, Julian Dyson, Brian A. Walker, Antonio Leonardi, Angela Chambery, Christoph Driessen, Pieter Sonneveld, Gareth Morgan, Antonio Palumbo, Anna Tramontano, Amin Rahemtulla, Menotti Ruvo, Guido Franzoso

Publikováno v: Cancer Cell

Summary Constitutive NF-κB signaling promotes survival in multiple myeloma (MM) and other cancers; however, current NF-κB-targeting strategies lack cancer cell specificity. Here, we identify the interaction between the NF-κB-regulated antiapoptoti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa807c597b910aa2661eb68d64a833f3

Performance of PSMA-targeted radiotheranostics in an experimental model of renal cell carcinoma.

Autor: Singh R; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States., Thotakura AK; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States., Alati S; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States., Lisok A; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States., Jiang Z; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States., Merino VF; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States., Minn I; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States., Yadav S; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, United States., Markowski MC; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, United States.; Department of Urology, Brady Urological Institute, Johns Hopkins University, Baltimore, MD, United States., Ged Y; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, United States.; Department of Urology, Brady Urological Institute, Johns Hopkins University, Baltimore, MD, United States., Pavlovich CP; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, United States.; Department of Urology, Brady Urological Institute, Johns Hopkins University, Baltimore, MD, United States., Singla N; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, United States.; Department of Urology, Brady Urological Institute, Johns Hopkins University, Baltimore, MD, United States., Solnes LB; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, United States., Gorin MA; The Milton and Carroll Petrie Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Pomper MG; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, United States.; Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States., Rowe SP; Department of Radiology, University of North Carolina, Chapel Hill, NC, United States., Banerjee SR; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, United States.

Publikováno v: Frontiers in oncology [Front Oncol] 2024 Sep 10; Vol. 14, pp. 1432286. Date of Electronic Publication: 2024 Sep 10 (Print Publication: 2024).

Exhausted T cells hijacking the cancer-immunity cycle: Assets and liabilities.

Autor: Brunell AE; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.; Immuno-Oncology, Oncology Research, Orion Corporation, Turku, Finland., Lahesmaa R; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland., Autio A; Immuno-Oncology, Oncology Research, Orion Corporation, Turku, Finland., Thotakura AK; Immuno-Oncology, Oncology Research, Orion Corporation, Turku, Finland.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Apr 14; Vol. 14, pp. 1151632. Date of Electronic Publication: 2023 Apr 14 (Print Publication: 2023).

The Role of Medical Treatment in Chronic Subdural Hematoma.

Autor: Thotakura AK; Department of Neurosurgery, NRI Academy of Sciences, Guntur, Andhra Pradesh, India., Marabathina NR; Department of Neurosurgery, NRI Academy of Sciences, Guntur, Andhra Pradesh, India.

Publikováno v: Asian journal of neurosurgery [Asian J Neurosurg] 2018 Oct-Dec; Vol. 13 (4), pp. 976-983.

Role of serial ultrasonic optic nerve sheath diameter monitoring in head injury.

Autor: Thotakura AK; Department of Neurosurgery, NRI Medical College and General Hospital, Chinakakani, Mangalagiri, Guntur, 522503 Andhra Pradesh, India. Electronic address: doctoramitkumar@gmail.com., Marabathina NR; Department of Neurosurgery, NRI Medical College and General Hospital, Chinakakani, Mangalagiri, Guntur, 522503 Andhra Pradesh, India., Danaboyina AR; Department of Radiology, NRI Medical College and General Hospital, Chinakakani, Mangalagiri, Guntur, 522503 Andhra Pradesh, India., Mareddy RR; Department of Neurosurgery, NRI Medical College and General Hospital, Chinakakani, Mangalagiri, Guntur, 522503 Andhra Pradesh, India.

Publikováno v: Neuro-Chirurgie [Neurochirurgie] 2017 Dec; Vol. 63 (6), pp. 444-448. Date of Electronic Publication: 2017 Nov 06.