Zobrazeno 1 - 10 of 50 pro vyhledávání: '"Thota Sambaiah"'
1
Structural study and thermodynamic characterization of inhibitor binding to lumazine synthase from Bacillus anthracis
Autor: Thota Sambaiah, Rudolf Ladenstein, Adelbert Bacher, Mark Cushman, Markus Fischer, Sabine Saller, Aleksander Popov, Boris Illarionov, Ekaterina Morgunova
Publikováno v: Acta Crystallographica Section D: Biological Crystallography
Crystallographic studies of lumazine synthase, the penultimate enzyme of the riboflavin-biosynthetic pathway in B. anthracis, provide a structural framework for the design of antibiotic inhibitors, together with calorimetric and kinetic investigation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01aca7dd623fdc545d4709a3cdd3af6f
https://doi.org/10.1107/s0907444910029690
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2
Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis
Autor: Thota Sambaiah, Ekaterina Morgunova, Rudolf Ladenstein, Adelbert Bacher, Mark Cushman, Markus Fischer, Ilka Haase, Boris Illarionov
Publikováno v: FEBS Journal. 273:4790-4804
Recently published genomic investigations of the human pathogen Mycobacterium tuberculosis have revealed that genes coding the proteins involved in riboflavin biosynthesis are essential for the growth of the organism. Because the enzymes involved in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4dedd8df05db9887853aa12fb5b6341
https://doi.org/10.1111/j.1742-4658.2006.05481.x
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3
Akademický článek
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6
Stereoselective [2 + 2 + 2] cocyclotrimerization of oxa- and azabenzonorbornadienes † with alkynes catalyzed by nickel complexes: first transition metal-mediated synthesis of isobenzofuran and isoindole precursors
Autor: Daw-Jen Huang, Thota Sambaiah, Chien-Hong Cheng
Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :195-203
Oxabenzonorbornadiene (1a) reacted with various alkynes in the presence of Ni(PPh3)2Cl2, PPh3 and zinc powder in toluene to give two common products 2a and 2b regardless of the alkyne used. The formation of 2a and 2b are proposed to be from the Diels
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4012e10c90c85a45b7737e309312eb50
https://doi.org/10.1039/a907654i
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7
Nickel-Catalyzed Highly Stereoselective Ring Opening of 7-Oxa- and Azanorbornenes with Organic Halides
Autor: Malay Nandi, Thota Sambaiah, Chiou-Chii Feng, Chien-Hong Cheng
Publikováno v: The Journal of Organic Chemistry. 64:3538-3543
Nickel-catalyzed ring-opening reactions of 7-heteroatom norbornadienes and norbornenes with various organic halides to give products with multiple stereocenters are described. Treatment of 7-oxabenzonorbornadiene (1a) and 7-carbomethoxy-7-azabenzonor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db6eab56255665fa85d2583125a299ca
https://doi.org/10.1021/jo982312e
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8
Highly Regio- and Stereoselective Cocyclotrimerization and Linear Cotrimerization of α,β-Unsaturated Carbonyl Compounds with Alkynes Catalyzed by Nickel Complexes
Autor: Dinesh Kumar Rayabarapu, Daw-Jen Huang, Thota Sambaiah, Cheng-Hong Lin, Lih-Ping Li, Chien-Hong Cheng
Publikováno v: The Journal of Organic Chemistry. 64:3663-3670
Cyclic enones 2-cyclohexen-1-one (1a), 4,4-dimethyl-2-cyclohexen-1-one (1b), 2-cyclopenten-1-one (1c), and 2-cyclohepten-1-one (1d) react with octa-1,7-diyne (2) in THF in the presence of Ni(PPh(3))(2)I(2), ZnI(2), and Zn powder at 62 degrees C to gi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd055de3e3c25697451cf007bf76ca8
https://doi.org/10.1021/jo9900580
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9
Phototoxicity of some novel porphyrin hybrids against the human leukemic cell line TF-1
Autor: Thota Sambaiah, Angèle Viola, Goverdhan Mehta, Michel Julliard, Patrice Mannoni, Sengodagounder Muthusamy, Michel Chanon, Bhaskar G. Maiya
Publikováno v: Journal of Photochemistry and Photobiology B: Biology. 40:263-272
Photodynamic induced cytotoxicity by porphyrin-DNA cross linker/intercalator hybrid diads and triads has been studied on the human leukemic cell line TF-1. Cells were incubated for 1 to 4 h with these new photosensitizers and irradiated with white li
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21eb02e7d5303a0e7de7ea9ffb50bf04
https://doi.org/10.1016/s1011-1344(97)00067-5
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10
Design and synthesis of new taxol-containing aminophosphates as protaxols
Autor: Chien-Hui Lieu, Yiu-Kay Lai, Jih Ru Hwu, Himatkumar V. Patel, Shwu-Chen Tsay, Thota Sambaiah, Gholam H. Hakimelahi
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:545-548
Taxol-containing aminophosphates 5–7 were synthesized as protaxols by a “one-flask” method; the intrinsic zwitterionic character increases their solubility to about six times higher than that of taxol in a phosphate buffer solution.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24466d55f65c258ed957a811d387e0db
https://doi.org/10.1016/s0960-894x(97)00058-9
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