Zobrazeno 1 - 10 of 38 pro vyhledávání: '"Thorsten Schaefer"'
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Akademický článek
Nuclear and cytosolic fractions of SOX2 synergize as transcriptional and translational co-regulators of cell fate
Autor: Thorsten Schaefer, Nitish Mittal, Hui Wang, Meric Ataman, Silvia Candido, Jonas Lötscher, Sergiy Velychko, Lionel Tintignac, Thomas Bock, Anastasiya Börsch, Jochen Baßler, Tata Nageswara Rao, Jakub Zmajkovic, Sarah Roffeis, Jordan Löliger, Francis Jacob, Alain Dumlin, Christoph Schürch, Alexander Schmidt, Radek C. Skoda, Matthias P. Wymann, Christoph Hess, Hans R. Schöler, Holm Zaehres, Ed Hurt, Mihaela Zavolan, Claudia Lengerke
Publikováno v: Cell Reports, Vol 43, Iss 10, Pp 114807- (2024)
Summary: Stemness and pluripotency are mediated by transcriptional master regulators that promote self-renewal and repress cell differentiation, among which is the high-mobility group (HMG) box transcription factor SOX2. Dysregulated SOX2 expression,
Externí odkaz: https://doaj.org/article/3f4435c1df914aa5bdc0b2931130faf7
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2
Akademický článek
SOX2 and p53 Expression Control Converges in PI3K/AKT Signaling with Versatile Implications for Stemness and Cancer
Autor: Thorsten Schaefer, Rebekah Steiner, Claudia Lengerke
Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 14, p 4902 (2020)
Stemness and reprogramming involve transcriptional master regulators that suppress cell differentiation while promoting self-renewal. A distinguished example thereof is SOX2, a high mobility group (HMG)-box transcription factor (TF), whose subcellula
Externí odkaz: https://doaj.org/article/e05a36ef733548fe913de9ba107f650e
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4
Supplementary figure 7-8 and Table 2 from Prominent Oncogenic Roles of EVI1 in Breast Carcinoma
Autor: Claudia Lengerke, Klaus Schulze-Osthoff, Lothar Kanz, Tanja N. Fehm, Holger Moch, Sven Perner, Francis Jacob, Selina Reich, Anna M. Paczulla, Zsuzsanna Varga, Martin Braun, Martina Konantz, Thorsten Schaefer, Hui Wang
Gene expression patterns associated with EVI1 knockdown or overexpression in BC, schematic illustration of potential EVI1 binding sites in the KISS1 promotor and control experiments for ChIP analyses; note included primer sequences.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4033ac2eb553dc64db7032bd675b5271
https://doi.org/10.1158/0008-5472.22416467.v1
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Supplementary figure 9-10 from Prominent Oncogenic Roles of EVI1 in Breast Carcinoma
Autor: Claudia Lengerke, Klaus Schulze-Osthoff, Lothar Kanz, Tanja N. Fehm, Holger Moch, Sven Perner, Francis Jacob, Selina Reich, Anna M. Paczulla, Zsuzsanna Varga, Martin Braun, Martina Konantz, Thorsten Schaefer, Hui Wang
Validation of KISS1 mRNA overexpression in BC cells transduced with KISS1 overexpression lentiviruses and verification of the effects of KISS1 induction or RKI-1447/Kp-10 supplementation, on migration/growth of Hs 578T or MDA-MB-231 control cells.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e9288d82925b836ce2057eaa4c1db9
https://doi.org/10.1158/0008-5472.22416464
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Data from Prominent Oncogenic Roles of EVI1 in Breast Carcinoma
Autor: Claudia Lengerke, Klaus Schulze-Osthoff, Lothar Kanz, Tanja N. Fehm, Holger Moch, Sven Perner, Francis Jacob, Selina Reich, Anna M. Paczulla, Zsuzsanna Varga, Martin Braun, Martina Konantz, Thorsten Schaefer, Hui Wang
Overexpression of the EVI1 oncogene is associated typically with aggressive myeloid leukemia, but is also detectable in breast carcinoma where its contributions are unexplored. Analyzing a tissue microarray of 608 breast carcinoma patient specimens,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013b5882267cb597991110229596137b
https://doi.org/10.1158/0008-5472.c.6509558.v1
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