Výsledky vyhledávání - "Thorsten R. Mempel"

Akademický článek

Translational Studies Using the MALT1 Inhibitor (S)-Mepazine to Induce Treg Fragility and Potentiate Immune Checkpoint Therapy in Cancer

Autor: Mauro Di Pilato, Yun Gao, Yi Sun, Amina Fu, Carina Grass, Thomas Seeholzer, Regina Feederle, Irina Mazo, Samuel W. Kazer, Kevin Litchfield, Ulrich H. von Andrian, Thorsten R. Mempel, Russell W. Jenkins, Daniel Krappmann, Peter Keller

Publikováno v: Journal of Immunotherapy and Precision Oncology, Vol 6, Iss 2, Pp 61-73 (2023)

Introduction: Regulatory T cells (Tregs) play a critical role in the maintenance of immune homeostasis but also protect tumors from immune-mediated growth control or rejection and pose a significant barrier to effective immunotherapy. Inhibition of M

Externí odkaz: https://doaj.org/article/dc5e74a62a884d328a611a253bea0c01

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Akademický článek

HIV-1-Induced Small T Cell Syncytia Can Transfer Virus Particles to Target Cells through Transient Contacts

Autor: Menelaos Symeonides, Thomas T. Murooka, Lauren N. Bellfy, Nathan H. Roy, Thorsten R. Mempel, Markus Thali

Publikováno v: Viruses, Vol 7, Iss 12, Pp 6590-6603 (2015)

HIV-1 Env mediates fusion of viral and target cell membranes, but it can also mediate fusion of infected (producer) and target cells, thus triggering the formation of multinucleated cells, so-called syncytia. Large, round, immobile syncytia are readi

Externí odkaz: https://doaj.org/article/37ce931e48ba49c1b534cc940f6dec14

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Akademický článek

Behavior of Endogenous Tumor-Associated Macrophages Assessed In Vivo Using a Functionalized Nanoparticle

Autor: Antoine Leimgruber, Cedric Berger, Virna Cortez-Retamozo, Martin Etzrodt, Andita P. Newton, Peter Waterman, Jose Luiz Figueiredo, Rainer H. Kohler, Natalie Elpek, Thorsten R. Mempel, Filip K. Swirski, Matthias Nahrendorf, Ralph Weissleder, Mikael J. Pittet

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 5, Pp 459-468 (2009)

Tumor-associated macrophages (TAMs) invade the tumor stroma in many cancers, yet their role is incompletely understood. To visualize and better understand these critical cells in tumor progression, we screened a portfolio of rationally selected, inje

Externí odkaz: https://doaj.org/article/f91897bdee8d4dae93dee63ddf5784b3

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Akademický článek

Combining precision oncology and immunotherapy by targeting the MALT1 protease

Autor: Thorsten R Mempel, Daniel Krappmann

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 10 (2022)

An innovative strategy for cancer therapy is to combine the inhibition of cancer cell-intrinsic oncogenic signaling with cancer cell-extrinsic immunological activation of the tumor microenvironment (TME). In general, such approaches will focus on two

Externí odkaz: https://doaj.org/article/d970d35cc2f44483ad9205418463629d

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Interruption of the Intratumor CD8:Treg Crosstalk Improves the Efficacy of PD-1 Immunotherapy

Autor: Shannon N Geels, Alexander Moshensky, Rachel S Sousa, Benjamin L Walker, Rima Singh, Giselle Gutierrez, Michael Hwang, Thorsten R Mempel, Qing Nie, Shivashankar Othy, Francesco Marangoni

Publikováno v: bioRxiv

SUMMARYPD-1 blockade unleashes the potent antitumor activity of CD8 cells but can also promote immunosuppressive T regulatory (Treg) cells, which may worsen response to immunotherapy. Tumor Treg inhibition is a promising strategy to overcome therapeu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ffddb517949b0983b73039083b78c90
https://europepmc.org/articles/PMC10245792/

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Inhibition of CDK4/6 Promotes CD8 T-cell Memory Formation

Publikováno v: Cancer discovery, vol 11, iss 10
Cancer Discov

CDK4/6 inhibitors are approved to treat breast cancer and are in trials for other malignancies. We examined CDK4/6 inhibition in mouse and human CD8+ T cells during early stages of activation. Mice receiving tumor-specific CD8+ T cells treated with C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::764cc8feac27854a89e0549eeafb9ff4
https://doi.org/10.1158/2159-8290.cd-20-1540

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