Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Thorsten Melcher"'
1
Biology-guided radiotherapy: redefining the role of radiotherapy in metastatic cancer
Autor: C. Huntzinger, P. Olcott, Shervin M. Shirvani, Judy Bartlett-Roberto, Yevgen Voronenko, Thorsten Melcher, Samuel Mazin
Publikováno v: The British Journal of Radiology
The emerging biological understanding of metastatic cancer and proof-of-concept clinical trials suggest that debulking all gross disease holds great promise for improving patient outcomes. However, ablation of multiple targets with conventional exter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad06a25f388257ad0737f9bbb42551de
https://pubmed.ncbi.nlm.nih.gov/33112685
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2
18F-EF5 PET Imaging as an Early Response Biomarker for the Hypoxia-Activated Prodrug SN30000 Combined with Radiation Treatment in a Non–Small Cell Lung Cancer Xenograft Model
Autor: Thorsten Melcher, Gerald T. Bida, Satish K. Chitneni, William R. Wilson, Gregory M. Palmer, Hong Yuan, Michael P. Hay, Michael R. Zalutsky, Mark W. Dewhirst
Publikováno v: Journal of Nuclear Medicine. 54:1339-1346
Hypoxia is a significant therapeutic problem for solid tumors because hypoxic cells are treatment-resistant and more aggressive. Hypoxia-activated prodrugs such as SN30000 use a mechanism of activation in hypoxic cells similar to that of 2-nitroimida
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4820bbafdf45d97b3f92df61d6122d75
https://doi.org/10.2967/jnumed.112.116293
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4
Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma
Autor: Roger F. Castilho, Thorsten Melcher, Mirella Gonzalez-Zulueta, Gregor Tomasevic, Gunilla Gidö, Karoly Nikolich, Gustav Mattiasson, Mehrdad Shamloo, Tadeusz Wieloch, Kavitha Mathi, Saili Yi, Craig H Warden
Publikováno v: Nature Medicine. 9:1062-1068
Whereas uncoupling protein 1 (UCP-1) is clearly involved in thermogenesis, the role of UCP-2 is less clear. Using hybridization, cloning techniques and cDNA array analysis to identify inducible neuroprotective genes, we found that neuronal survival c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9233d8c9ac797d48235fc8a5e4739249
https://doi.org/10.1038/nm903
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7
Candidate editases for GluR channels in single neurons of rat hippocampus and cerebellum
Autor: Peter H. Seeburg, Georg Köhr, Thorsten Melcher
Publikováno v: Neuropharmacology
RNA editing by site selective adenosine deamination changes codons in several nuclear transcripts in the mammalian brain and affects critical properties of the encoded proteins, as exemplified by the calcium permeability of AMPA receptor channels. Th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29a45375a34e7d0d785ce0c4f892aa4
https://doi.org/10.1016/s0028-3908(98)00149-x
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8
RED2, a Brain-specific Member of the RNA-specific Adenosine Deaminase Family
Autor: Anne Herb, Miyoko Higuchi, Rolf Sprengel, Peter H. Seeburg, Stefan Maas, Thorsten Melcher
Publikováno v: Journal of Biological Chemistry. 271:31795-31798
The mammalian RNA-specific adenosine deaminases DRADA/dsRAD (alias ADAR) and RED1 (alias ADARB1) have been implicated in the site-selective editing of brain-expressed pre-mRNAs for glutamate receptor subunits and of antigenomic RNA of hepatitis delta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b5982bf8cd6cf044e98421e41659c8
https://doi.org/10.1074/jbc.271.50.31795
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