Výsledky vyhledávání - "Thorsten Loeck"

Acidic Growth Conditions Promote Epithelial-to-Mesenchymal Transition to Select More Aggressive PDAC Cell Phenotypes In Vitro

Autor: Madelaine Magalì Audero, Tiago Miguel Amaral Carvalho, Federico Alessandro Ruffinatti, Thorsten Loeck, Maya Yassine, Giorgia Chinigò, Antoine Folcher, Valerio Farfariello, Samuele Amadori, Chiara Vaghi, Albrecht Schwab, Stephan J. Reshkin, Rosa Angela Cardone, Natalia Prevarskaya, Alessandra Fiorio Pla

Publikováno v: Cancers; Volume 15; Issue 9; Pages: 2572

Pancreatic Ductal Adenocarcinoma (PDAC) is characterized by an acidic microenvironment, which contributes to therapeutic failure. So far there is a lack of knowledge with respect to the role of the acidic microenvironment in the invasive process. Thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fdd3cf3c72e0c729dfcd52d2e82882

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The role of the Na

Autor: Thorsten, Loeck, Albrecht, Schwab

Publikováno v: Biological chemistryReferences.

Cancer is characterized by uncontrolled growth, invasion, and metastasis. In addition to solid cancer cells, cancer-associated fibroblasts (CAFs) play important roles in cancer pathophysiology. They arise from "healthy" cells but get manipulated by s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f05a605270dd89046d8ff2e5eb0745f2
https://pubmed.ncbi.nlm.nih.gov/36594183

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Inhibition of the Na+/Ca2+ exchanger (NCX) regulates pancreatic stellate cell migration in a way depending on cues from the tumor microenvironment

Autor: Thorsten Loeck, M. Rugi, Z. Pethö, A. Schwab

Publikováno v: Pancreatology. 22:e28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c633971d5ce13b0b66bdf2199d88c4e1
https://doi.org/10.1016/j.pan.2022.06.077

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STIM2: Redox-sensor and effector of the (tumor) microenvironment

Autor: Albrecht Schwab, Thorsten Loeck, Karolina Najder-Nalepa

Publikováno v: Cell Calcium. 94:102335

Ion channels and their associated proteins are at the interface between the cytosol and the extracellular space. In cancer, this allows them to sense and transduce physico-chemical cues from the tumor microenvironment and thereby shape the aggressive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41228ba18d02b0dc06845855ceaf47d7
https://doi.org/10.1016/j.ceca.2020.102335

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