Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Thorsten Kirschberg"'
Autor:
Weimei Xing, Ona Barauskas, Thorsten Kirschberg, Anita Niedziela-Majka, Michael Clarke, Gabriel Birkus, Perry Weissburg, Xiaohong Liu, Brian E Schultz, Roman Sakowicz, HyockJoo Kwon, Joy Y Feng
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181969 (2017)
Influenza polymerase is a heterotrimer composed of polymerase acidic protein A (PA) and basic proteins 1 (PB1) and 2 (PB2). The endonuclease active site, located in the PA subunit, cleaves host mRNA to prime viral mRNA transcription, and is essential
Externí odkaz:
https://doaj.org/article/214d6c14bef247f8a2cf1c7bae8f111c
Autor:
Hyock Joo Kwon, Weimei Xing, Katie Chan, Anita Niedziela-Majka, Katherine M Brendza, Thorsten Kirschberg, Darryl Kato, John O Link, Guofeng Cheng, Xiaohong Liu, Roman Sakowicz
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122844 (2015)
Ledipasvir, a direct acting antiviral agent (DAA) targeting the Hepatitis C Virus NS5A protein, exhibits picomolar activity in replicon cells. While its mechanism of action is unclear, mutations that confer resistance to ledipasvir in HCV replicon ce
Externí odkaz:
https://doaj.org/article/2ec4378953f54de7b0076a7adeb703bd
Autor:
Brian Law, Tripta Rughwani, Tenley C. Archer, Lekha Kumar, Daniel Lu, Priyanka Somanath, Yan Ma, Xiaodong Wang, David Sperandio, Steve Morris, Thorsten Kirschberg, Mini Balakrishnan, Thomas Butler
Publikováno v:
Blood. 140:6191-6192
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5289e3a5d2cf691cf379d3acb110ca0
https://doi.org/10.1182/blood-2022-170445
https://doi.org/10.1182/blood-2022-170445
Publikováno v:
Journal of Hepatology. 73:S684
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96c4decb2d2ec12aec630fe031ae4c99
https://doi.org/10.1016/s0168-8278(20)31829-8
https://doi.org/10.1016/s0168-8278(20)31829-8
Autor:
Kelly Wang, James G. Taylor, Elsa Mondou, Mike Matles, Yang Zheng-Yu, Yujin Wang, Hongtao Liu, Jianyu Sun, Yang Tian, Guofeng Cheng, Hongyan Guo, Lianhong Xu, Melanie Cornpropst, Jason K. Perry, Michael L. Mitchell, Thorsten Kirschberg, Kato Darryl, Manoj C. Desai, Chris Yang, Neil H. Squires, John O. Link, Terry Kellar, Erik Mogalian, Jay P. Parrish
Publikováno v:
Journal of Medicinal Chemistry. 57:2033-2046
A new class of highly potent NS5A inhibitors with an unsymmetric benzimidazole-difluorofluorene-imidazole core and distal [2.2.1]azabicyclic ring system was discovered. Optimization of antiviral potency and pharmacokinetics led to the identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e01a36ec6ef38fbdea906289d7749e6
https://doi.org/10.1021/jm401499g
https://doi.org/10.1021/jm401499g
Autor:
John O, Link, James G, Taylor, Lianhong, Xu, Michael, Mitchell, Hongyan, Guo, Hongtao, Liu, Darryl, Kato, Thorsten, Kirschberg, Jianyu, Sun, Neil, Squires, Jay, Parrish, Terry, Kellar, Zheng-Yu, Yang, Chris, Yang, Mike, Matles, Yujin, Wang, Kelly, Wang, Guofeng, Cheng, Yang, Tian, Erik, Mogalian, Elsa, Mondou, Melanie, Cornpropst, Jason, Perry, Manoj C, Desai
Publikováno v:
Journal of Medicinal Chemistry. 59:7696-7696
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f802da9d546512d021a4229f8b8f45
https://doi.org/10.1021/acs.jmedchem.6b01043
https://doi.org/10.1021/acs.jmedchem.6b01043
Autor:
Thorsten, Kirschberg, Jay, Parrish
Publikováno v:
Current opinion in drug discoverydevelopment. 10(4)
Processes involving the creation and modification of oligomeric nucleotide substrates are key events in the replication cycles of many viruses, and have been successful targets for much pharmaceutical research. Because of high levels of intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::484a1ecd35c8b72e105863b5492cbfac
https://pubmed.ncbi.nlm.nih.gov/17659488
https://pubmed.ncbi.nlm.nih.gov/17659488
Autor:
Thorsten Kirschberg, Hendrik Helmke
Publikováno v:
Nachrichten aus Chemie, Technik und Laboratorium. 43:341-342
Im Rahmen des Graduiertenkollegs “Hochreaktive Mehrfachbindungssysteme” hatten G. Erker und J. Grobe vom 16. bis 18. November 1994 schon zum zweiten Mal nach Munster eingeladen. “Organic and Inorganic Chemistry of Reactive C=X π-Systems” war
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27613756ff6fbb01885c06fb68e71c3f
https://doi.org/10.1002/nadc.19950430318
https://doi.org/10.1002/nadc.19950430318