Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Thorsten Forster"'
Autor:
Rory Taylor, Chengyuan Zhang, Deslit George, Sarah Kotecha, Mariam Abdelghaffar, Thorsten Forster, Patricia Dos Santos Rodrigues, Alexander C. Reisinger, Daniel White, Fergus Hamilton, W. John Watkins, David M. Griffith, Peter Ghazal
Publikováno v:
EBioMedicine, Vol 100, Iss , Pp 104981- (2024)
Summary: Background: Mechanistic studies have established a biological role of sterol metabolism in infection and immunity with clinical data linking deranged cholesterol metabolism during sepsis with poorer outcomes. In this systematic review we ass
Externí odkaz:
https://doaj.org/article/c4ca1ee0b24e424d8cba2b2e11ad2989
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Background: Whole blood expression profiling is a mainstay for delineating differential diagnostic signatures of infection yet is subject to high variability that reduces power and complicates clinical usefulness. To date, confirmatory high confidenc
Externí odkaz:
https://doaj.org/article/80f772acf43648779617514378597931
Autor:
Paul Dickinson, Claire L. Smith, Thorsten Forster, Marie Craigon, Alan J. Ross, Mizan R. Khondoker, Alasdair Ivens, David J. Lynn, Judith Orme, Allan Jackson, Paul Lacaze, Katie L. Flanagan, Benjamin J. Stenson, Peter Ghazal
Publikováno v:
Genomics Data, Vol 3, Iss C, Pp 41-48 (2015)
Neonatal infection remains a primary cause of infant morbidity and mortality worldwide and yet our understanding of how human neonates respond to infection remains incomplete. Changes in host gene expression in response to infection may occur in any
Externí odkaz:
https://doaj.org/article/d54f889f318f4447bd703971eee188f3
Autor:
Widad Dantoft, Pablo Martínez-Vicente, James Jafali, Lara Pérez-Martínez, Kim Martin, Konstantinos Kotzamanis, Marie Craigon, Manfred Auer, Neil T. Young, Paul Walsh, Arnaud Marchant, Ana Angulo, Thorsten Forster, Peter Ghazal
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Neonates and especially premature infants are highly susceptible to infection but still can have a remarkable resilience that is poorly understood. The view that neonates have an incomplete or deficient immune system is changing. Human neonatal studi
Externí odkaz:
https://doaj.org/article/d9077d58e65b4a29a7a12f22c62445c4
Autor:
Kevin A Robertson, Wei Yuan Hsieh, Thorsten Forster, Mathieu Blanc, Hongjin Lu, Peter J Crick, Eylan Yutuc, Steven Watterson, Kimberly Martin, Samantha J Griffiths, Anton J Enright, Mami Yamamoto, Madapura M Pradeepa, Kimberly A Lennox, Mark A Behlke, Simon Talbot, Jürgen Haas, Lars Dölken, William J Griffiths, Yuqin Wang, Ana Angulo, Peter Ghazal
Publikováno v:
PLoS Biology, Vol 14, Iss 3, p e1002364 (2016)
In invertebrates, small interfering RNAs are at the vanguard of cell-autonomous antiviral immunity. In contrast, antiviral mechanisms initiated by interferon (IFN) signaling predominate in mammals. Whilst mammalian IFN-induced miRNA are known to inhi
Externí odkaz:
https://doaj.org/article/2a7e4b86c96d49edbfa01de93c137949
Autor:
Kai A Kropp, Wei Yuan Hsieh, Elena Isern, Thorsten Forster, Eva Krause, Wolfram Brune, Ana Angulo, Peter Ghazal
Publikováno v:
PLoS Pathogens, Vol 11, Iss 4, p e1004737 (2015)
Viral engagement with macrophages activates Toll-Like-Receptors (TLRs) and viruses must contend with the ensuing inflammatory responses to successfully complete their replication cycle. To date, known counter-strategies involve the use of viral-encod
Externí odkaz:
https://doaj.org/article/c1d165f3a79f4109a0475fd6f6bc3ca8
Autor:
Anna M Hoy, Rachel J Lundie, Alasdair Ivens, Juan F Quintana, Norman Nausch, Thorsten Forster, Frances Jones, Narcis B Kabatereine, David W Dunne, Francisca Mutapi, Andrew S Macdonald, Amy H Buck
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 2, p e2701 (2014)
MicroRNAs (miRNAs) are a class of short non-coding RNA that play important roles in disease processes in animals and are present in a highly stable cell-free form in body fluids. Here, we examine the capacity of host and parasite miRNAs to serve as t
Externí odkaz:
https://doaj.org/article/b794d4cab0984b058bee5ee827781f68
Autor:
Mathieu Blanc, Wei Yuan Hsieh, Kevin A Robertson, Steven Watterson, Guanghou Shui, Paul Lacaze, Mizanur Khondoker, Paul Dickinson, Garwin Sing, Sara Rodríguez-Martín, Peter Phelan, Thorsten Forster, Birgit Strobl, Matthias Müller, Rudolph Riemersma, Timothy Osborne, Markus R Wenk, Ana Angulo, Peter Ghazal
Publikováno v:
PLoS Biology, Vol 9, Iss 3, p e1000598 (2011)
Little is known about the protective role of inflammatory processes in modulating lipid metabolism in infection. Here we report an intimate link between the innate immune response to infection and regulation of the sterol metabolic network characteri
Externí odkaz:
https://doaj.org/article/cc2f259066284ec9a4077c68a828c24a
About This BookCreate R programs that exploit the computational capability of your cloud platforms and computers to the fullestBecome an expert in writing the most efficient and highest performance parallel algorithms in RGet to grips with the concep
Publikováno v:
Toner, T M, Pancholi, R, Miller, P, Forster, T, Coleman, H G & Overton, I M 2023, ' Strategies and techniques for quality control and semantic enrichment with multimodal data: a case study in colorectal cancer with eHDPrep ', Gigascience, vol. 12, giad030 . https://doi.org/10.1093/gigascience/giad030
Background Integration of data from multiple domains can greatly enhance the quality and applicability of knowledge generated in analysis workflows. However, working with health data is challenging, requiring careful preparation in order to support m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b083520c80f08523d51488eb467b705
https://pure.qub.ac.uk/en/publications/f0bc4292-838c-44b5-8a11-ca2f2bf6867c
https://pure.qub.ac.uk/en/publications/f0bc4292-838c-44b5-8a11-ca2f2bf6867c