Zobrazeno 1 - 10
of 441
pro vyhledávání: '"Thorsten Buch"'
Autor:
Linda Schellhammer, Michal Beffinger, Ulisse Salazar, Jon D. Laman, Thorsten Buch, Johannes vom Berg
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108132- (2023)
Summary: Treating brain diseases requires therapeutics to pass the blood-brain barrier (BBB) which is nearly impermeable for large biologics such as antibodies. Several methods now facilitate crossing or circumventing the BBB for antibody therapeutic
Externí odkaz:
https://doaj.org/article/580a05e2a23b461a878f7a5cb959618b
Autor:
Daniela C. Ivan, Kristina Carolin Berve, Sabrina Walthert, Gianni Monaco, Katharina Borst, Elisa Bouillet, Filipa Ferreira, Henry Lee, Jasmin Steudler, Thorsten Buch, Marco Prinz, Britta Engelhardt, Giuseppe Locatelli
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract Signaling by insulin-like growth factor-1 (IGF-1) is essential for the development of the central nervous system (CNS) and regulates neuronal survival and myelination in the adult CNS. In neuroinflammatory conditions including multiple scler
Externí odkaz:
https://doaj.org/article/a963821709be460bb9d9a0e0b95caaad
Autor:
Herwig Grimm, Nikola Biller-Andorno, Thorsten Buch, Maik Dahlhoff, Gail Davies, Christopher R. Cederroth, Otto Maissen, Wilma Lukas, Elisa Passini, Elin Törnqvist, I. Anna S. Olsson, Jenny Sandström
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
The 3Rs principle of replacing, reducing and refining the use of animals in science has been gaining widespread support in the international research community and appears in transnational legislation such as the European Directive 2010/63/EU, a numb
Externí odkaz:
https://doaj.org/article/e9d2ba6a12be4ddd801056e43d49c605
Autor:
Prajwal Prajwal, Turlough Neary, Katja Rohrbach, Pascal Bittel, Pauline C. Göller, Thorsten Buch, Sebastian Dümcke, Peter M. Keller
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
IntroductionTuberculosis (TB) is an infectious disease caused by the group of bacterial pathogens Mycobacterium tuberculosis complex (MTBC) and is one of the leading causes of death worldwide. Timely diagnosis and treatment of drug-resistant TB is a
Externí odkaz:
https://doaj.org/article/fd0e3d5231d24bafb23cee7ff66b3a3d
Autor:
Julia K Prümmer, Veronika M Stein, Eliane Marti, Andreas Lutterotti, Ilijas Jelcic, Gertraud Schüpbach-Regula, Thorsten Buch, Arianna Maiolini
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0280864 (2023)
BackgroundMeningoencephalitis of unknown origin (MUO) is an inflammatory disease of the canine central nervous system (CNS) that shares several features with multiple sclerosis (MS) in humans. In approximately 95% of MS patients, ≥ two immunoglobul
Externí odkaz:
https://doaj.org/article/9dd07a3618ac4d9c8e84b0b1d575d1e8
Autor:
Julia K. Prümmer, Veronika M. Stein, Eliane Marti, Mario Ziegler, Andreas Lutterotti, Ilijas Jelcic, Frank Steffen, Thorsten Buch, Arianna Maiolini
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
Isoelectric focusing followed by immunoblotting is a method routinely used in human medicine to assess the presence of oligoclonal bands (OCBs) in cerebrospinal fluid (CSF) and serum. The detection of OCBs is a valuable diagnostic test, especially im
Externí odkaz:
https://doaj.org/article/7d4d04b4f0ee42799e144e8c772cb9db
Autor:
Stephanie Musiol, Francesca Alessandrini, Constanze A. Jakwerth, Adam M. Chaker, Evelyn Schneider, Ferdinand Guerth, Benjamin Schnautz, Johanna Grosch, Ileana Ghiordanescu, Julia T. Ullmann, Josephine Kau, Mirjam Plaschke, Stefan Haak, Thorsten Buch, Carsten B. Schmidt-Weber, Ulrich M. Zissler
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
TGF-β1 is known to have a pro-inflammatory impact by inducing Th9 and Th17 cells, while it also induces anti-inflammatory Treg cells (Tregs). In the context of allergic airway inflammation (AAI) its dual role can be of critical importance in influen
Externí odkaz:
https://doaj.org/article/2107742a722a4451ab2e2106650214cb
Autor:
Dominik Alterauge, Johannes W. Bagnoli, Frank Dahlström, Barry M. Bradford, Neil A. Mabbott, Thorsten Buch, Wolfgang Enard, Dirk Baumjohann
Publikováno v:
Cell Reports, Vol 33, Iss 1, Pp 108232- (2020)
Summary: T follicular helper (Tfh) cells are crucial for the establishment of germinal centers (GCs) and potent antibody responses. Nevertheless, the T cell-intrinsic factors that are required for the maintenance of already-established Tfh cells and
Externí odkaz:
https://doaj.org/article/ea8fd1b9470741f09b63bd229d9ad242
Autor:
Robert Janowski, Gitta A. Heinz, Andreas Schlundt, Nina Wommelsdorf, Sven Brenner, Andreas R. Gruber, Michael Blank, Thorsten Buch, Raymund Buhmann, Mihaela Zavolan, Dierk Niessing, Vigo Heissmeyer, Michael Sattler
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Roquin is an RNA-binding protein that prevents autoimmunity by limiting expression of receptors such as Ox40. Here, the authors identify an RNA structure that they describe as an alternative decay element, and they characterise its interaction with R
Externí odkaz:
https://doaj.org/article/be1a189912b647edb8ff00db7603f09a
Autor:
Olivia Prazeres da Costa, Arthur Hoffman, Johannes W Rey, Ulrich Mansmann, Thorsten Buch, Achim Tresch
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91840 (2014)
IntroductionMany studies examine gene expression data that has been obtained under the influence of multiple factors, such as genetic background, environmental conditions, or exposure to diseases. The interplay of multiple factors may lead to effect
Externí odkaz:
https://doaj.org/article/6a8a645ed2eb47bbbc37454bfa88e351