Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Thorsten Boroviak"'
Autor:
Sophie Kraunsoe, Takuya Azami, Yihan Pei, Graziano Martello, Kenneth Jones, Thorsten Boroviak, Jennifer Nichols
Publikováno v:
Biology Open, Vol 12, Iss 1 (2023)
Externí odkaz:
https://doaj.org/article/916538a548e04ce4b6967421618bff61
Autor:
Musashi Kubiura-Ichimaru, Christopher Penfold, Kazuaki Kojima, Constance Dollet, Haruka Yabukami, Katsunori Semi, Yasuhiro Takashima, Thorsten Boroviak, Hideya Kawaji, Knut Woltjen, Aki Minoda, Erika Sasaki, Toshiaki Watanabe
SummaryPrimate germ cell development remains largely unexplored due to limitations in sample collection and the long duration of development. In mice, primordial germ cell-like cells (PGCLCs) derived from pluripotent stem cells (PSCs) can develop int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d811b9f4bff310e4f03c64bb985b9111
https://doi.org/10.1101/2022.09.20.508677
https://doi.org/10.1101/2022.09.20.508677
Autor:
Timo N Kohler, Magdalena Schindler, Anna L. Ellermann, Dylan Siriwardena, Florian Hollfelder, Erin Slatery, Clara Munger, Thorsten Boroviak
Publikováno v:
Stem Cell Reports
Summary Human periimplantation development requires the transformation of the naive pluripotent epiblast into a polarized epithelium. Lumenogenesis plays a critical role in this process, as the epiblast undergoes rosette formation and lumen expansion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147f0d63165d48a83852190a79672ddb
http://europepmc.org/articles/PMC8185981
http://europepmc.org/articles/PMC8185981
Autor:
Takuya Azami, Sophie Kraunsoe, Graziano Martello, Yihan Pei, Thorsten Boroviak, Jennifer Nichols
STAT3 has been studied extensively in the context of self-renewal of naïve pluripotent mouse embryonic stem cells. We uncovered acute roles for STAT3 and its target, TFCP2L1, in maintenance of epiblast and primitive endoderm during in vivo diapause.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6d589ce4333bc24fb7e630d2c72ac1b
https://doi.org/10.1101/2022.03.08.483469
https://doi.org/10.1101/2022.03.08.483469
Autor:
Christopher A. Penfold, Magdalena Schindler, Sophie Bergmann, Clara Munger, Thorsten Boroviak
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
The uterus is the organ for embryo implantation and fetal development. Most current models of the uterus are centred around capturing its function during later stages of pregnancy to increase the survival in pre-term births. However, in vitro models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792daaf42da3a53a69bec20610adf8ff
https://www.repository.cam.ac.uk/handle/1810/326071
https://www.repository.cam.ac.uk/handle/1810/326071
Autor:
Lawrence E. Bates, Jennifer Nichols, José C. R. Silva, Thorsten Boroviak, Giuliano Giuseppe Stirparo, Siarhei Hladkou, Agata Kurowski, Hannah T. Stuart, Stanley E. Strawbridge, Ayaka Yanagida
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We used single-cell whole-genome transcriptional profiling and protein quantification to investigate the role of OCT4 in establishing pluripotency in the murine embryo. Surprisingly, most pluripotency-associated factors are induced norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43e422ba3658d70d42d43bde35188c7
https://doi.org/10.1073/pnas.2008890118
https://doi.org/10.1073/pnas.2008890118
Autor:
Thorsten Boroviak, Hisham Mohammed, Irene Hernando-Herraez, Paul Bertone, Austin Smith, Giuliano Giuseppe Stirparo, Erika Sasaki, Sabine Dietmann, Jennifer Nichols, Wolf Reik
The mouse embryo is the canonical model for mammalian preimplantation development. Recent advances in single-cell profiling allow detailed analysis of embryogenesis in other eutherian species, including human, to distinguish conserved from divergent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1800b01c6c84b527295e1acf775d4a6
https://doi.org/10.1101/385815
https://doi.org/10.1101/385815
Autor:
Jennifer Nichols, Paul Bertone, Austin Smith, Ge Guo, Giuliano Giuseppe Stirparo, Thorsten Boroviak
Single-cell profiling techniques create opportunities to delineate cell fate progression in mammalian development. Recent studies have provided transcriptome data from human pre-implantation embryos, in total comprising nearly 2000 individual cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33c236ed6bf4eaa4ec3f25b73f14b82
https://europepmc.org/articles/PMC6110148/
https://europepmc.org/articles/PMC6110148/
Autor:
Áine M. Prendergast, Andreas Trumpp, Simon Haas, Frank Edenhofer, Daniel Baumgärtner, Nina Cabezas-Wallscheid, Alejandro Reyes, Lisa von Paleske, Ann Atzberger, Roberta Scognamiglio, Austin Smith, Marieke A.G. Essers, Thorsten Boroviak, Ulrich Kloz, Philipp Wörsdörfer, Paul Bertone, Marc Thier, Larissa S. Carnevalli, Wolfgang Huber, Franciscus van der Hoeven, Robert N. Eisenman, Sandro Altamura
Publikováno v:
Cell
Mouse embryonic stem cells (ESCs) are maintained in a naive ground state of pluripotency in the presence of MEK and GSK3 inhibitors. Here, we show that ground-state ESCs express low Myc levels. Deletion of both c-myc and N-myc (dKO) or pharmacologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0541d26265d7db56454e6ccc62fc4cbb
Autor:
Thorsten, Boroviak, Jennifer, Nichols
Publikováno v:
Development (Cambridge, England)
Naïve pluripotent mouse embryonic stem cells (ESCs) resemble the preimplantation epiblast and efficiently contribute to chimaeras. Primate ESCs correspond to the postimplantation embryo and fail to resume development in chimaeric assays. Recent data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::87108d6ebd307956aa5c47dc90cff09c
https://pubmed.ncbi.nlm.nih.gov/28096211
https://pubmed.ncbi.nlm.nih.gov/28096211