Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Thorsten Berg"'
Autor:
Jan Nagenborg, Han Jin, Adele V. Ruder, Lieve Temmerman, Barend Mees, Casper Schalkwijk, Daniel Müller-Klieser, Thorsten Berg, Pieter Goossens, Marjo M. P. C. Donners, Erik A. L. Biessen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionInhibition of STAT5 was recently reported to reduce murine atherosclerosis. However, the role of STAT5 isoforms, and more in particular STAT5A in macrophages in the context of human atherosclerosis remains unknown.Methods and resultsHere,
Externí odkaz:
https://doaj.org/article/206556e531ef4ffba0deaedda5baeca5
Autor:
Sara Abdelfatah, Angela Berg, Qi Huang, Li Jun Yang, Sami Hamdoun, Anette Klinger, Henry J. Greten, Edmond Fleischer, Thorsten Berg, Vincent K.W. Wong, Thomas Efferth
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 1021-1034 (2019)
Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Po
Externí odkaz:
https://doaj.org/article/5d92f179f9394a6dad8794c0b9488b8b
Publikováno v:
Methods and Protocols, Vol 5, Iss 6, p 93 (2022)
The signal transducer and activation of transcription (STAT) proteins are a family of Src homology 2 (SH2) domain-containing transcription factors. The family member STAT4 is a mediator of IL-12 signalling and has been implicated in the pathogenesis
Externí odkaz:
https://doaj.org/article/0b3e7580f48a4bf1af6e31d23ce0526b
Autor:
Nagarajan Elumalai, Angela Berg, Stefan Rubner, Linda Blechschmidt, Chen Song, Kalaiselvi Natarajan, Jörg Matysik, Thorsten Berg
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract The transcription factor STAT5b is a target for tumour therapy. We recently reported catechol bisphosphate and derivatives such as Stafib-1 as the first selective inhibitors of the STAT5b SH2 domain. Here, we demonstrate STAT5b binding of ca
Externí odkaz:
https://doaj.org/article/7eb0fb05f08d4517a3fb77233ccd9bc2
Autor:
Veronika Riedl, Matthias Portius, Lara Heiser, Philipp Riedl, Torsten Jakob, Rosa Gehring, Thorsten Berg, Tilo Pompe
Publikováno v:
Journal of Materials Chemistry B. 11:4695-4702
For perspective biosensing applications, we demonstrate the synthesis of sulfamethoxazole derivatives and their site-directed coupling to microfluidic generated hydrogel microparticles.
Autor:
Jie Liu, Shubhadip Mallick, Yusheng Xie, Corentin Grassin, Belén Lucas, Beate Schölermann, Axel Pahl, Rebecca Scheel, Carsten Strohmann, Christoph Protzel, Thorsten Berg, Christian Merten, Slava Ziegler, Herbert Waldmann
Publikováno v:
Angewandte Chemie International Edition. 62
Autor:
Michael A. Grotzer, Alexandre Arcaro, Angelika Eggert, Thorsten Berg, Daniela De Martino, Tarek Shalaby, Frank Speleman, Massimo Zollo, Katleen De Preter, Candy Kumps, Urs Ziegler, Valeria Di Dato, Giulio Fiaschetti, Deborah Castelletti
The quassinoid analogue NBT-272 has been reported to inhibit MYC, thus warranting a further effort 7to better understand its preclinical properties in models of embryonal tumors (ET), a family of childhood malignancies sharing relevant biological and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef7236e60eb3c24bfeb782fa8fde597
https://doi.org/10.1158/1535-7163.c.6531777
https://doi.org/10.1158/1535-7163.c.6531777
Autor:
Michael A. Grotzer, Alexandre Arcaro, Angelika Eggert, Thorsten Berg, Daniela De Martino, Tarek Shalaby, Frank Speleman, Massimo Zollo, Katleen De Preter, Candy Kumps, Urs Ziegler, Valeria Di Dato, Giulio Fiaschetti, Deborah Castelletti
Supplementary Data from The Quassinoid Derivative NBT-272 Targets Both the AKT and ERK Signaling Pathways in Embryonal Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3191a8d878f0be8286c64362534b38bc
https://doi.org/10.1158/1535-7163.22485108.v1
https://doi.org/10.1158/1535-7163.22485108.v1
Autor:
Florian Nietzold, Stefan Rubner, Beata Labuzek, Przemysław Golik, Ewa Surmiak, Xabier del Corte, Radoslaw Kitel, Christoph Protzel, Regina Reppich‐Sacher, Jan Stichel, Katarzyna Magiera‐Mularz, Tad A. Holak, Thorsten Berg
Publikováno v:
ChemBioChem. 24
Nutlin-3a is a reversible inhibitor of the p53/MDM2 interaction. We have synthesized the derivative Nutlin-3a-aa bearing an additional exocyclic methylene group in the piperazinone moiety. Nutlin-3a-aa is more active than Nutlin-3a against purified w
Publikováno v:
Chembiochem : a European journal of chemical biology. 24(1)
The transcription factors STAT5a and STAT5b are constitutively active in many human tumors. Combined inhibition of both STAT5 proteins is a valuable approach with promising applications in tumor biology. We recently reported resorcinol bisphosphate a